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Cellosaurus MC/CAR (CVCL_1397)

[Text version]
Cell line name MC/CAR
Synonyms MC-CAR; MCCAR
Accession CVCL_1397
Resource Identification Initiative To cite this cell line use: MC/CAR (RRID:CVCL_1397)
Comments Group: Patented cell line.
Problematic cell line: Misclassified. Originally thought to be a myeloma cell line but is a B-lymphoblastoid cell line (PubMed=10516762).
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-8083.
Population: Caucasian.
Characteristics: Produces IgG1 kappa.
Doubling time: 19.94 hours (Patent=US4434230).
Microsatellite instability: Stable (MSS) (Sanger).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Transcriptomics; Microarray.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.32
Native American0
East Asian, North0
East Asian, South0
South Asian0
European, North66.92
European, South32.76
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_6671 (MC/CAR-Z2)
Sex of cell Male
Age at sampling 81Y
Category Transformed cell line
STR profile Source(s): ATCC=CRL-8083; Cosmic-CLP=683665; IZSLER=BS TCL 134

Markers:
AmelogeninX,Y
CSF1PO11,12
D2S133816,20
D3S135815,16
D5S81811,14
D7S8209,13
D8S117910,13
D13S31711,13
D16S53911,12
D18S5115
D19S43313
D21S1130 (IZSLER=BS TCL 134)
30,31.2 (ATCC=CRL-8083)
FGA19,20
Penta D9,10
Penta E7,12
TH016,9
TPOX8
vWA17,18

Run an STR similarity search on this cell line
Publications

Patent=US4434230
Roy E. Ritts Jr.;
Human nonsecretory plasmacytoid cell line.
Patent number US4434230, 28-Feb-1984

PubMed=2537114; DOI=10.1182/blood.V73.2.566.566
Christophe Duperray, Bernard Klein, Brian G.M. Durie, X. Zhang, Michel Jourdan, Philippe Poncelet, Francois Favier, Claude Vincent, Jean Brochier, Gilbert Marcel Lenoir, Francois-Regis Bataille;
Phenotypic analysis of human myeloma cell lines.
Blood 73:566-572(1989)

PubMed=10516762; DOI=10.1038/sj.leu.2401510
Hans Gunther Drexler, Wilhelm Gerhard Dirks, Roderick A.F. MacLeod;
False human hematopoietic cell lines: cross-contaminations and misinterpretations.
Leukemia 13:1601-1607(1999)

DOI=10.1007/0-306-46877-8_4
Helena Jernberg-Wiklund, Kenneth Nilsson;
Multiple myeloma cell lines.
(In book chapter) Human cell culture. Vol. 3. Cancer cell lines part 3; Masters, John R.W. & Palsson, Bernhard Orn (eds.); pp.81-155; Kluwer Academic Publishers; New York; USA (2000)

PubMed=10936422; DOI=10.1016/S0145-2126(99)00195-2
Hans Gunther Drexler, Yoshinobu Matsuo;
Malignant hematopoietic cell lines: in vitro models for the study of multiple myeloma and plasma cell leukemia.
Leuk. Res. 24:681-703(2000)

PubMed=12068308; DOI=10.1038/nature00766
Helen R. Davies, Graham Robert Bignell, Charles Cox, Philip J. Stephens, Sarah Edkins, Sheila Clegg, Jon W. Teague, Hayley Woffendin, Mathew J. Garnett, William Bottomley, Neil Davis ...Show all 52 authors... , Ed Dicks, Rebecca Ewing, Yvonne Floyd, Kristian Gray, Sarah Hall, Rachel Hawes, Jaime Hughes, Vivian Kosmidou, Andrew Menzies, Catherine Mould, Adrian Parker, Claire Stevens, Stephen Watt, Steven Hooper, Rebecca Wilson, Hiran Jayatilake, Barry Austin Gusterson, Colin S. Cooper, Janet M. Shipley, Darren Hargrave, Kathy Pritchard-Jones, Norman J. Maitland, Georgia Chenevix-Trench, Gregory J. Riggins, Darell Doty Bigner, Giuseppe Palmieri, Antonio Cossu, Adrienne M. Flanagan, Andrew Nicholson, Judy W.C. Ho, Suet Yi Leung, Siu Tsan Yuen, Barbara L. Weber, Hilliard Foster Seigler, Timothy L. Darrow, Hugh F. Paterson, Richard Marais, Christopher John Marshall, Richard Wooster, Michael Rudolf Stratton, P. Andrew Futreal; Show fewer authors
Mutations of the BRAF gene in human cancer.
Nature 417:949-954(2002)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line collections (Providers) ATCC; CRL-8083
CCTCC; GDC0324
IZSLER; BS TCL 134
Cell line databases/resources CLO; CLO_0007575
CLDB; cl5227
CCRID; 4201HUM-CCTCC00324
Cell_Model_Passport; SIDM00636
Cosmic-CLP; 683665
DepMap; ACH-002270
IGRhCellID; MCCAR
LINCS_LDP; LCL-1538
Biological sample resources BioSample; SAMN03471132
Chemistry resources ChEMBL-Cells; CHEMBL3308240
ChEMBL-Targets; CHEMBL2366274
GDSC; 683665
PharmacoDB; MCCAR_885_2019
PubChem_Cell_line; CVCL_1397
Encyclopedic resources Wikidata; Q54904190
Experimental variables resources EFO; EFO_0002229
Gene expression databases ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-3610
GEO; GSM1670075
Polymorphism and mutation databases Cosmic; 683665
Cosmic; 2131565
IARC_TP53; 21487
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number38