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Cellosaurus KP-N-SI9s (CVCL_1340)

[Text version]
Cell line name KP-N-SI9s
Synonyms KP-N-SI9S; KPNSI9s; KPNSI9S; SI9s
Accession CVCL_1340
Resource Identification Initiative To cite this cell line use: KP-N-SI9s (RRID:CVCL_1340)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Japanese.
Characteristics: Substrate-adherent type (S-type) (PubMed=2019470).
Doubling time: ~49 hours (Note=Lot 12152017) (JCRB=IFO50433).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Misspelling: KP-N-S19s; Note=Occasionally.
Derived from site: Metastatic; Left axillary lymph node; UBERON=UBERON_0001097.
Sequence variations
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Ala (c.35G>C); ClinVar=VCV000045122; Zygosity=Heterozygous (DepMap).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0
East Asian, North75.78
East Asian, South24.21
South Asian0
European, North0
European, South0
Disease Adrenal gland neuroblastoma (NCIt: C4827)
Neuroblastoma (ORDO: Orphanet_635)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_7910 (KP-N-SI(LA))
Sex of cell Male
Age at sampling 5Y
Category Cancer cell line
STR profile Source(s): JCRB

Markers:
AmelogeninX,Y
CSF1PO10
D5S81813
D7S8208,11
D13S31711,14
D16S5399,13
TH016
TPOX8,11
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=2019470; DOI=10.1002/ijc.2910480221
Sugimoto T., Ueyama H., Hosoi H., Inazawa J., Kato T., Kemshead J.T., Reynolds C.P., Gown A.M., Mine H., Sawada T.
Alpha-smooth-muscle actin and desmin expressions in human neuroblastoma cell lines.
Int. J. Cancer 48:277-283(1991)

PubMed=11129446; DOI=10.1097/00019606-200012000-00007
Sugimoto T., Mine H., Horii Y., Takahashi K., Nagai R., Morishita R., Komada M., Asada Y., Sawada T.
Neuroblastoma cell lines showing smooth muscle cell phenotypes.
Diagn. Mol. Pathol. 9:221-228(2000)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections (Providers) JCRB; IFO50433
Cell line databases/resources cancercelllines; CVCL_1340
Cell_Model_Passport; SIDM00016
DepMap; ACH-000446
Biological sample resources BioSample; SAMN03472791
BioSample; SAMN10987824
Chemistry resources PharmacoDB; KPNS19s_787_2019
Encyclopedic resources Wikidata; Q54900399
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2770
GEO; GSM887240
GEO; GSM888314
GEO; GSM1670006
Polymorphism and mutation databases Cosmic; 907315
IARC_TP53; 21441
IARC_TP53; 30109
LiGeA; CCLE_193
Progenetix; CVCL_1340
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number27