ID   KP-N-SI9s
AC   CVCL_1340
SY   KP-N-SI9S; KPNSI9s; KPNSI9S; SI9s
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-2770
DR   BioSample; SAMN03472791
DR   BioSample; SAMN10987824
DR   cancercelllines; CVCL_1340
DR   Cell_Model_Passport; SIDM00016
DR   Cosmic; 907315
DR   DepMap; ACH-000446
DR   GEO; GSM887240
DR   GEO; GSM888314
DR   GEO; GSM1670006
DR   IARC_TP53; 21441
DR   IARC_TP53; 30109
DR   JCRB; IFO50433
DR   LiGeA; CCLE_193
DR   PharmacoDB; KPNS19s_787_2019
DR   Progenetix; CVCL_1340
DR   Wikidata; Q54900399
RX   PubMed=2019470;
RX   PubMed=11129446;
RX   PubMed=20164919;
RX   PubMed=22460905;
RX   PubMed=30894373;
RX   PubMed=31068700;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Population: Japanese.
CC   Characteristics: Substrate-adherent type (S-type) (PubMed=2019470).
CC   Doubling time: ~49 hours (Note=Lot 12152017) (JCRB=IFO50433).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Ala (c.35G>C); ClinVar=VCV000045122; Zygosity=Heterozygous (DepMap).
CC   Omics: Deep exome analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Genome ancestry: African=0%; Native American=0%; East Asian, North=75.78%; East Asian, South=24.21%; South Asian=0%; European, North=0%; European, South=0% (PubMed=30894373).
CC   Misspelling: KP-N-S19s; Note=Occasionally.
CC   Derived from site: Metastatic; Left axillary lymph node; UBERON=UBERON_0001097.
ST   Source(s): JCRB
ST   Amelogenin: X,Y
ST   CSF1PO: 10
ST   D13S317: 11,14
ST   D16S539: 9,13
ST   D5S818: 13
ST   D7S820: 8,11
ST   TH01: 6
ST   TPOX: 8,11
ST   vWA: 17
DI   NCIt; C4827; Adrenal gland neuroblastoma
DI   ORDO; Orphanet_635; Neuroblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_7910 ! KP-N-SI(LA)
SX   Male
AG   5Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 27
//
RX   PubMed=2019470; DOI=10.1002/ijc.2910480221;
RA   Sugimoto T., Ueyama H., Hosoi H., Inazawa J., Kato T., Kemshead J.T.,
RA   Reynolds C.P., Gown A.M., Mine H., Sawada T.;
RT   "Alpha-smooth-muscle actin and desmin expressions in human
RT   neuroblastoma cell lines.";
RL   Int. J. Cancer 48:277-283(1991).
//
RX   PubMed=11129446; DOI=10.1097/00019606-200012000-00007;
RA   Sugimoto T., Mine H., Horii Y., Takahashi K., Nagai R., Morishita R.,
RA   Komada M., Asada Y., Sawada T.;
RT   "Neuroblastoma cell lines showing smooth muscle cell phenotypes.";
RL   Diagn. Mol. Pathol. 9:221-228(2000).
//
RX   PubMed=20164919; DOI=10.1038/nature08768;
RA   Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S.,
RA   Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S.,
RA   Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T.,
RA   Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.;
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=22460905; DOI=10.1038/nature11003;
RA   Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A.,
RA   Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A.,
RA   Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J.,
RA   Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E.,
RA   Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J.,
RA   Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C.,
RA   Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C.,
RA   Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P.,
RA   Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L.,
RA   Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R.,
RA   Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.;
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//