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Cellosaurus HuO9 (CVCL_1298)

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Cell line name HuO9
Synonyms Huo9; HUO9; Hu09
Accession CVCL_1298
Resource Identification Initiative To cite this cell line use: HuO9 (RRID:CVCL_1298)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Japanese.
Characteristics: Established from a xenograft established in athymic nude mice after five passages.
Doubling time: 57 hours (PubMed=2170070); 43.3 hours (PubMed=14669798).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: H3K4me1 ChIP-seq epigenome analysis.
Omics: H3K27ac ChIP-seq epigenome analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Bone, right distal femur; UBERON=UBERON_0004406.
Sequence variations
  • Mutation; HGNC; 11998; TP53; None_reported; -; Zygosity=- (PubMed=9359923).
HLA typing Source: PubMed=15289353
Class I
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American0
East Asian, North77.77
East Asian, South13.74
South Asian0
European, North1.78
European, South3.83
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_WL11 (HuO9-H3)CVCL_WL12 (HuO9-L12)CVCL_WL13 (HuO9-L13)
CVCL_WL14 (HuO9-L6)CVCL_R725 (HuO9-M112)CVCL_R726 (HuO9-M132)
CVCL_JG37 (HuO9/CMV-Luc)
Originate from same individual CVCL_2958 ! HuO9N2
Sex of cell Female
Age at sampling 13Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=907072; DepMap=ACH-001526; JCRB=JCRB0427

Penta D11,13
Penta E17,21

Run an STR similarity search on this cell line

PubMed=2691514; DOI=10.1007/BF00391353
Kawai A., Ozaki T., Ikeda S., Oda T., Miyazaki M., Sato J., Taketa K., Inoue H.
Two distinct cell lines derived from a human osteosarcoma.
J. Cancer Res. Clin. Oncol. 115:531-536(1989)

PubMed=2170070; DOI=10.1097/00003086-199010000-00036
Kawai A.
A newly established human osteosarcoma cell line with osteoblastic properties.
Clin. Orthop. Relat. Res. 259:256-267(1990)

Mihara K., Miyazaki M., Fushimi K., Tsuji T., Inoue Y., Fukaya K.-i., Ohashi R., Namba M.
The p53 gene status and other cellular characteristics of human cell lines maintained in our laboratory.
Tissue Cult. Res. Commun. 16:173-178(1997)

PubMed=9359923; DOI=10.18926/AMO/30789
Mihara K., Miyazaki M., Kondo T., Fushimi K., Tsuji T., Inoue Y., Fukaya K.-i., Ishioka C., Namba M.
Yeast functional assay of the p53 gene status in human cell lines maintained in our laboratory.
Acta Med. Okayama 51:261-265(1997)

PubMed=12405284; DOI=10.1023/A:1020395816633
Kimura K., Nakano T., Park Y.-B., Tani M., Tsuda H., Beppu Y., Moriya H., Yokota J.
Establishment of human osteosarcoma cell lines with high metastatic potential to lungs and their utilities for therapeutic studies on metastatic osteosarcoma.
Clin. Exp. Metastasis 19:477-485(2002)

PubMed=14669798; DOI=10.1023/A:1027355610603
Nakano T., Tani M., Ishibashi Y., Kimura K., Park Y.-B., Imaizumi N., Tsuda H., Aoyagi K., Sasaki H., Ohwada S., Yokota J.
Biological properties and gene expression associated with metastatic potential of human osteosarcoma.
Clin. Exp. Metastasis 20:665-674(2003)

PubMed=15289353; DOI=10.1158/0008-5472.CAN-04-0522
Tsukahara T., Nabeta Y., Kawaguchi S., Ikeda H., Sato Y., Shimozawa K., Ida K., Asanuma H., Hirohashi Y., Torigoe T., Hiraga H., Nagoya S., Wada T., Yamashita T., Sato N.
Identification of human autologous cytotoxic T-lymphocyte-defined osteosarcoma gene that encodes a transcriptional regulator, papillomavirus binding factor.
Cancer Res. 64:5442-5448(2004)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=26320182; DOI=10.18632/oncotarget.5177
Ren L., Mendoza A., Zhu J., Briggs J.W., Halsey C., Hong E.S., Burkett S.S., Morrow J.J., Lizardo M.M., Osborne T., Li S.Q., Luu H.H., Meltzer P.S., Khanna C.
Characterization of the metastatic phenotype of a panel of established osteosarcoma cells.
Oncotarget 6:29469-29481(2015)

PubMed=26351324; DOI=10.1158/1535-7163.MCT-15-0074
Teicher B.A., Polley E.C., Kunkel M., Evans D., Silvers T.E., Delosh R.M., Laudeman J., Ogle C., Reinhart R., Selby M., Connelly J., Harris E., Monks A., Morris J.
Sarcoma cell line screen of oncology drugs and investigational agents identifies patterns associated with gene and microRNA expression.
Mol. Cancer Ther. 14:2452-2462(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=29334376; DOI=10.1038/nm.4475
Morrow J.J., Bayles I., Funnell A.P.W., Miller T.E., Saiakhova A., Lizardo M.M., Bartels C.F., Kapteijn M.Y., Hung S., Mendoza A., Dhillon G., Chee D.R., Myers J.T., Allen F., Gambarotti M., Righi A., DiFeo A., Rubin B.P., Huang A.Y., Meltzer P.S., Helman L.J., Picci P., Versteeg H., Stamatoyannopoulos J.A., Khanna C., Scacheri P.C.
Positively selected enhancer elements endow osteosarcoma cells with metastatic competence.
Nat. Med. 24:176-185(2018)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cell line collections (Providers) JCRB; JCRB0427
Cell line databases/resources CLO; CLO_0009875
cancercelllines; CVCL_1298
Cell_Model_Passport; SIDM00599
Cosmic-CLP; 907072
DepMap; ACH-001526
Biological sample resources BioSample; SAMN03471626
Chemistry resources ChEMBL-Cells; CHEMBL3308748
ChEMBL-Targets; CHEMBL1075476
GDSC; 907072
PharmacoDB; HuO9_643_2019
PubChem_Cell_line; CVCL_1298
Encyclopedic resources Wikidata; Q54896887
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM320823
GEO; GSM1669921
GEO; GSM1676303
GEO; GSM1701638
GEO; GSM1914988
GEO; GSM1914989
GEO; GSM1914990
GEO; GSM1914991
Polymorphism and mutation databases Cosmic; 907072
Cosmic; 931040
IARC_TP53; 21390
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number39