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Cellosaurus D425 Med (CVCL_1275)

[Text version]
Cell line name D425 Med
Synonyms D-425 Med; D-425 Med-C; D-425MED; D425_Med; D425MED; D425Med; Med 425; D-425; D425; H425
Accession CVCL_1275
Resource Identification Initiative To cite this cell line use: D425 Med (RRID:CVCL_1275)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Doubling time: 2.58 days (PubMed=1904513).
Omics: Deep exome analysis.
Derived from site: In situ; Brain, posterior fossa; UBERON=UBERON_0008788.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Val274Cys (c.820_821GT>TG); Zygosity=Unspecified (PubMed=22343310; DepMap).
Disease Medulloblastoma, non-WNT/non-SHH, group 3 (NCIt: C129445)
Medulloblastoma (ORDO: Orphanet_616)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_1161 ! D458 Med
Sex of cell Male
Age at sampling 6Y
Category Cancer cell line
STR profile Source(s): Millipore

Markers:
AmelogeninX
CSF1PO9,12
D3S135814,17
D5S81812,13
D7S82011,12
D8S117911,15
D13S31711
D16S53911,12
D18S5115,17,18
D21S1129,33.2
FGA20,24
Penta D9,10
Penta E14,15
TH016,9.3
TPOX8
vWA16,17

Run an STR similarity search on this cell line
Publications

PubMed=2180567
Bigner S.H., Friedman H.S., Vogelstein B., Oakes W.J., Bigner D.D.
Amplification of the c-myc gene in human medulloblastoma cell lines and xenografts.
Cancer Res. 50:2347-2350(1990)

PubMed=1822845
Wikstrand C.J., Friedman H.S., Bigner D.D.
Medulloblastoma cell-substrate interaction in vitro.
Invasion Metastasis 11:310-324(1991)

PubMed=1904513
He X.-M., Wikstrand C.J., Friedman H.S., Bigner S.H., Pleasure S., Trojanowski J.Q., Bigner D.D.
Differentiation characteristics of newly established medulloblastoma cell lines (D384 Med, D425 Med, and D458 Med) and their transplantable xenografts.
Lab. Invest. 64:833-843(1991)

PubMed=11916498; DOI=10.1093/neuonc/4.2.75
Aldosari N., Wiltshire R.N., Dutra A., Schrock E., McLendon R.E., Friedman H.S., Bigner D.D., Bigner S.H.
Comprehensive molecular cytogenetic investigation of chromosomal abnormalities in human medulloblastoma cell lines and xenograft.
Neuro-oncol. 4:75-85(2002)

PubMed=20847082; DOI=10.1093/neuonc/noq091
Teider N., Scott D.K., Neiss A., Weeraratne S.D., Amani V.M., Wang Y.-F., Marquez V.E., Cho Y.-J., Pomeroy S.L.
Neuralized1 causes apoptosis and downregulates Notch target genes in medulloblastoma.
Neuro-oncol. 12:1244-1256(2010)

PubMed=21177782; DOI=10.1093/neuonc/noq179
Weeraratne S.D., Amani V.M., Neiss A., Teider N., Scott D.K., Pomeroy S.L., Cho Y.-J.
miR-34a confers chemosensitivity through modulation of MAGE-A and p53 in medulloblastoma.
Neuro-oncol. 13:165-175(2011)

PubMed=21667264; DOI=10.1007/s00726-011-0953-8
Azizi A.A., Li L., Strobel T., Chen W.-Q., Slavc I., Lubec G.
Identification of c-myc-dependent proteins in the medulloblastoma cell line D425Med.
Amino Acids 42:2149-2163(2012)

PubMed=22343310; DOI=10.1016/j.neulet.2012.02.022
Ghassemifar S., Mendrysa S.M.
MDM2 antagonism by nutlin-3 induces death in human medulloblastoma cells.
Neurosci. Lett. 513:106-110(2012)

PubMed=24297863; DOI=10.1158/1078-0432.CCR-13-2281
Bandopadhayay P., Bergthold G., Nguyen B., Schubert S., Gholamin S., Tang Y.-J., Bolin S., Schumacher S.E., Zeid R., Masoud S., Yu F.-R., Vue N., Gibson W.J., Paolella B.R., Mitra S.S., Cheshier S.H., Qi J., Liu K.-W., Wechsler-Reya R.J., Weiss W.A., Swartling F.J., Kieran M.W., Bradner J.E., Beroukhim R., Cho Y.-J.
BET bromodomain inhibition of MYC-amplified medulloblastoma.
Clin. Cancer Res. 20:912-925(2014)

PubMed=24300787; DOI=10.1158/1078-0432.CCR-13-2053
Erdreich-Epstein A., Robison N., Ren X.-H., Zhou H., Xu J.-Y., Davidson T.B., Schur M., Gilles F.H., Ji L.-Y., Malvar J., Shackleford G.M., Margol A.S., Krieger M.D., Judkins A.R., Jones D.T.W., Pfister S.M., Kool M., Sposto R., Asgharzadeh S.
PID1 (NYGGF4), a new growth-inhibitory gene in embryonal brain tumors and gliomas.
Clin. Cancer Res. 20:827-836(2014)

PubMed=27498314; DOI=10.1016/j.jbiotec.2016.07.028
Ivanov D.P., Coyle B., Walker D.A., Grabowska A.M.
In vitro models of medulloblastoma: choosing the right tool for the job.
J. Biotechnol. 236:10-25(2016)

PubMed=27812533; DOI=10.1016/j.dib.2016.10.004
Ivanov D.P., Walker D.A., Coyle B., Grabowska A.M.
Data on the number and frequency of scientific literature citations for established medulloblastoma cell lines.
Data Brief 9:696-698(2016)

Cross-references
Cell line collections (Providers) Millipore; SCC290
Cell line databases/resources cancercelllines; CVCL_1275
Cell_Model_Passport; SIDM01501
DepMap; ACH-001053
Lonza; 1683
CRISP screens repositories BioGRID_ORCS_Cell_line; 1665
Encyclopedic resources Wikidata; Q54817229
Gene expression databases GEO; GSM482334
GEO; GSM919359
Polymorphism and mutation databases Cosmic; 973264
Cosmic; 2362651
Cosmic; 2772985
Progenetix; CVCL_1275
Entry history
Entry creation04-Apr-2012
Last entry update30-Jan-2024
Version number24