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Cellosaurus D425 Med (CVCL_1275)

[Text version]
Cell line name D425 Med
Synonyms D-425 Med; D-425 Med-C; D-425MED; D425_Med; D425MED; D425Med; Med 425; D-425; D425; H425
Accession CVCL_1275
Resource Identification Initiative To cite this cell line use: D425 Med (RRID:CVCL_1275)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Doubling time: 2.58 days (PubMed=1904513).
Omics: Genomics; Whole exome sequencing.
Derived from site: In situ; Brain, posterior fossa; UBERON=UBERON_0008788.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Val274Cys (c.820_821GT>TG); Zygosity=Unspecified (PubMed=22343310; DepMap=ACH-001053).
Disease Medulloblastoma, non-WNT/non-SHH, group 3 (NCIt: C129445)
Medulloblastoma (ORDO: Orphanet_616)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_1161 ! D458 Med
Sex of cell Male
Age at sampling 6Y
Category Cancer cell line
STR profile Source(s): Millipore=SCC290

Markers:
AmelogeninX
CSF1PO9,12
D3S135814,17
D5S81812,13
D7S82011,12
D8S117911,15
D13S31711
D16S53911,12
D18S5115,17,18
D21S1129,33.2
FGA20,24
Penta D9,10
Penta E14,15
TH016,9.3
TPOX8
vWA16,17

Run an STR similarity search on this cell line
Publications

PubMed=2180567
Sandra H. Bigner, Henry Seth Friedman, Bert Vogelstein, W. Jerry Oakes, Darell Doty Bigner;
Amplification of the c-myc gene in human medulloblastoma cell lines and xenografts.
Cancer Res. 50:2347-2350(1990)

PubMed=1822845
Carol J. Wikstrand, Henry Seth Friedman, Darell Doty Bigner;
Medulloblastoma cell-substrate interaction in vitro.
Invasion Metastasis 11:310-324(1991)

PubMed=1904513
Xuan-Min He, Carol J. Wikstrand, Henry Seth Friedman, Sandra H. Bigner, Samuel J. Pleasure, John Quinn Trojanowski, Darell Doty Bigner;
Differentiation characteristics of newly established medulloblastoma cell lines (D384 Med, D425 Med, and D458 Med) and their transplantable xenografts.
Lab. Invest. 64:833-843(1991)

PubMed=11916498; DOI=10.1093/neuonc/4.2.75; PMCID=PMC1920654
Naji Aldosari, Rodney N. Wiltshire, Amalia Dutra, Evelin Schrock, Roger Edwin McLendon, Henry Seth Friedman, Darell Doty Bigner, Sandra H. Bigner;
Comprehensive molecular cytogenetic investigation of chromosomal abnormalities in human medulloblastoma cell lines and xenograft.
Neuro-oncol. 4:75-85(2002)

PubMed=20847082; DOI=10.1093/neuonc/noq091; PMCID=PMC3018940
Natalia Teider, Deborah K. Scott, Adrianne Neiss, Shyamal Dilhan Weeraratne, Vladimir M. Amani, Yi-Fei Wang, Victor E. Marquez, Yoon-Jae Cho, Scott L. Pomeroy;
Neuralized1 causes apoptosis and downregulates Notch target genes in medulloblastoma.
Neuro-oncol. 12:1244-1256(2010)

PubMed=21177782; DOI=10.1093/neuonc/noq179; PMCID=PMC3064629
Shyamal Dilhan Weeraratne, Vladimir M. Amani, Adrianne Neiss, Natalia Teider, Deborah K. Scott, Scott L. Pomeroy, Yoon-Jae Cho;
miR-34a confers chemosensitivity through modulation of MAGE-A and p53 in medulloblastoma.
Neuro-oncol. 13:165-175(2011)

PubMed=21667264; DOI=10.1007/s00726-011-0953-8
Amedeo A. Azizi, Lin Li, Thomas Strobel, Wei-Qiang Chen, Irene Slavc, Gert Lubec;
Identification of c-myc-dependent proteins in the medulloblastoma cell line D425Med.
Amino Acids 42:2149-2163(2012)

PubMed=22343310; DOI=10.1016/j.neulet.2012.02.022
Sara Ghassemifar, Susan M. Mendrysa;
MDM2 antagonism by nutlin-3 induces death in human medulloblastoma cells.
Neurosci. Lett. 513:106-110(2012)

PubMed=24297863; DOI=10.1158/1078-0432.CCR-13-2281; PMCID=PMC4198154
Pratiti Bandopadhayay, Guillaume Bergthold, Brian Nguyen, Simone Schubert, Sharareh Gholamin, Yu-Jie Tang, Sara Bolin, Steven E. Schumacher, Rhamy Zeid, Sabran Masoud, Fu-Rong Yu ...Show all 25 authors... , Nujsaubnusi Vue, William James Gibson, Brenton R. Paolella, Siddhartha Shankar Mitra, Samuel H. Cheshier, Jun Qi, Kun-Wei Liu, Robert J. Wechsler-Reya, William Andrew Weiss, Fredrik Johansson Swartling, Mark W. Kieran, James E. Bradner, Rameen Beroukhim, Yoon-Jae Cho; Show fewer authors
BET bromodomain inhibition of MYC-amplified medulloblastoma.
Clin. Cancer Res. 20:912-925(2014)

PubMed=24300787; DOI=10.1158/1078-0432.CCR-13-2053; PMCID=PMC3962776
Anat Erdreich-Epstein, Nathan Robison, Xiu-Hai Ren, Hong Zhou, Jing-Ying Xu, Tom B. Davidson, Mathew Schur, Floyd Harry Gilles, Ling-Yun Ji, Jemily Malvar, Gregory M. Shackleford ...Show all 19 authors... , Ashley Sloane Margol, Mark D. Krieger, Alexander Russell Judkins, David T.W. Jones, Stefan Michael Pfister, Marcel Kool, Richard Sposto, Shahab Asgharzadeh; Show fewer authors
PID1 (NYGGF4), a new growth-inhibitory gene in embryonal brain tumors and gliomas.
Clin. Cancer Res. 20:827-836(2014)

PubMed=27498314; DOI=10.1016/j.jbiotec.2016.07.028
Delyan P. Ivanov, Beth Coyle, David A. Walker, Anna M. Grabowska;
In vitro models of medulloblastoma: choosing the right tool for the job.
J. Biotechnol. 236:10-25(2016)

PubMed=27812533; DOI=10.1016/j.dib.2016.10.004; PMCID=PMC5079239
Delyan P. Ivanov, David A. Walker, Beth Coyle, Anna M. Grabowska;
Data on the number and frequency of scientific literature citations for established medulloblastoma cell lines.
Data Brief 9:696-698(2016)

Cross-references
Cell line collections (Providers) Millipore; SCC290
Cell line databases/resources cancercelllines; CVCL_1275
Cell_Model_Passport; SIDM01501
DepMap; ACH-001053
Lonza; 1683
CRISP screens repositories BioGRID_ORCS_Cell_line; 1665
Encyclopedic resources Wikidata; Q54817229
Gene expression databases GEO; GSM482334
GEO; GSM919359
Polymorphism and mutation databases Cosmic; 973264
Cosmic; 2362651
Cosmic; 2772985
Progenetix; CVCL_1275
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number27