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Cellosaurus D458 Med (CVCL_1161)

[Text version]
Cell line name D458 Med
Synonyms D-458 Med; D-458MED; D458MED; D458Med; Med 458; D-458; D458
Accession CVCL_1161
Resource Identification Initiative To cite this cell line use: D458 Med (RRID:CVCL_1161)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Doubling time: 3.45 days (PubMed=1904513).
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; Microarray.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Cerebrospinal fluid; UBERON=UBERON_0001359.
Sequence variations
Disease Medulloblastoma, non-WNT/non-SHH, group 3 (NCIt: C129445)
Medulloblastoma (ORDO: Orphanet_616)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_1275 ! D425 Med
Sex of cell Male
Age at sampling 6-7Y
Category Cancer cell line
Publications

PubMed=1822845
Carol J. Wikstrand, Henry Seth Friedman, Darell Doty Bigner;
Medulloblastoma cell-substrate interaction in vitro.
Invasion Metastasis 11:310-324(1991)

PubMed=1904513
Xuan-Min He, Carol J. Wikstrand, Henry Seth Friedman, Sandra H. Bigner, Samuel J. Pleasure, John Quinn Trojanowski, Darell Doty Bigner;
Differentiation characteristics of newly established medulloblastoma cell lines (D384 Med, D425 Med, and D458 Med) and their transplantable xenografts.
Lab. Invest. 64:833-843(1991)

PubMed=9283596; DOI=10.1016/S0165-4608(96)00404-9
Sandra H. Bigner, Roger Edwin McLendon, Herbert Edgar Fuchs, Paul Edward McKeever, Henry Seth Friedman;
Chromosomal characteristics of childhood brain tumors.
Cancer Genet. Cytogenet. 97:125-134(1997)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20847082; DOI=10.1093/neuonc/noq091; PMCID=PMC3018940
Natalia Teider, Deborah K. Scott, Adrianne Neiss, Shyamal Dilhan Weeraratne, Vladimir M. Amani, Yi-Fei Wang, Victor E. Marquez, Yoon-Jae Cho, Scott L. Pomeroy;
Neuralized1 causes apoptosis and downregulates Notch target genes in medulloblastoma.
Neuro-oncol. 12:1244-1256(2010)

PubMed=22343310; DOI=10.1016/j.neulet.2012.02.022
Sara Ghassemifar, Susan M. Mendrysa;
MDM2 antagonism by nutlin-3 induces death in human medulloblastoma cells.
Neurosci. Lett. 513:106-110(2012)

PubMed=24297863; DOI=10.1158/1078-0432.CCR-13-2281; PMCID=PMC4198154
Pratiti Bandopadhayay, Guillaume Bergthold, Brian Nguyen, Simone Schubert, Sharareh Gholamin, Yu-Jie Tang, Sara Bolin, Steven E. Schumacher, Rhamy Zeid, Sabran Masoud, Fu-Rong Yu ...Show all 25 authors... , Nujsaubnusi Vue, William James Gibson, Brenton R. Paolella, Siddhartha Shankar Mitra, Samuel H. Cheshier, Jun Qi, Kun-Wei Liu, Robert J. Wechsler-Reya, William Andrew Weiss, Fredrik Johansson Swartling, Mark W. Kieran, James E. Bradner, Rameen Beroukhim, Yoon-Jae Cho; Show fewer authors
BET bromodomain inhibition of MYC-amplified medulloblastoma.
Clin. Cancer Res. 20:912-925(2014)

PubMed=27498314; DOI=10.1016/j.jbiotec.2016.07.028
Delyan P. Ivanov, Beth Coyle, David A. Walker, Anna M. Grabowska;
In vitro models of medulloblastoma: choosing the right tool for the job.
J. Biotechnol. 236:10-25(2016)

PubMed=27812533; DOI=10.1016/j.dib.2016.10.004; PMCID=PMC5079239
Delyan P. Ivanov, David A. Walker, Beth Coyle, Anna M. Grabowska;
Data on the number and frequency of scientific literature citations for established medulloblastoma cell lines.
Data Brief 9:696-698(2016)

Cross-references
Cell line databases/resources cancercelllines; CVCL_1161
Cell_Model_Passport; SIDM01493
DepMap; ACH-001054
CRISP screens repositories BioGRID_ORCS_Cell_line; 1664
Encyclopedic resources Wikidata; Q54817230
Gene expression databases ArrayExpress; E-MTAB-783
GEO; GSM919360
GEO; GSM1234976
GEO; GSM1234977
Polymorphism and mutation databases Cosmic; 946381
IARC_TP53; 27691
Progenetix; CVCL_1161
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number26