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Cellosaurus H-EMC-SS (CVCL_1238)

[Text version]
Cell line name H-EMC-SS
Synonyms HEMCSS; HEMC-SS
Accession CVCL_1238
Resource Identification Initiative To cite this cell line use: H-EMC-SS (RRID:CVCL_1238)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Japanese.
Doubling time: 17.3-42.8 hours (CelloPub=CLPUB00044).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Variations; SNP array analysis.
Caution: Does not harbor a gene fusion involving EWSR1 which is a hallmark of extraskeletal myxoid chondrosarcoma (PubMed=34413129).
Derived from site: In situ; Muscle; UBERON=UBERON_0001630.
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.61
Native American0.67
East Asian, North77.11
East Asian, South20.07
South Asian0.1
European, North0.01
European, South1.42
Disease Extraskeletal myxoid chondrosarcoma (NCIt: C27502)
Extraskeletal myxoid chondrosarcoma (ORDO: Orphanet_209916)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 77Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=907290; DepMap=ACH-001519; RCB=RCB0508

Markers:
AmelogeninX
CSF1PO10,12
D3S135815,16
D5S81810,12
D7S8208,11
D8S117914,17
D13S3179 (RCB=RCB0508)
9,13 (Cosmic-CLP=907290; DepMap=ACH-001519)
D16S5399,13
D18S5116,24
D21S1130,32.2
FGA21,22
Penta D9,10
Penta E10,14
TH017,9
TPOX8
vWA14,17

Run an STR similarity search on this cell line
Publications

CLPUB00044
Fumio Ooshima;
Establishment of a new cell line from human extraskeletal myxoid chondrosarcoma.
Dokkyo J. Med. Sci. 19:1-9(1992)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=34413129; DOI=10.1158/1535-7163.MCT-21-0089; PMCID=PMC8571037
Jessica Gartrell, Marcia Mellado-Largarde, Michael R. Clay, Armita Bahrami, Natasha A. Sahr, April D. Sykes, Kaley Blankenship, Lauren Hoffmann, Jia Xie, Hyekyung P. Cho, Nathaniel Twarog ...Show all 21 authors... , Michele Connelly, Koon-Kiu Yan, Ji-Yang Yu, Shaina N. Porter, Shondra M. Pruett-Miller, Geoffrey Neale, Christopher L. Tinkle, Sara M. Federico, Elizabeth A. Stewart, Anang A. Shelat; Show fewer authors
SLFN11 is widely expressed in pediatric sarcoma and induces variable sensitization to replicative stress caused by DNA-damaging agents.
Mol. Cancer Ther. 20:2151-2165(2021)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) ECACC; 94042258
ICLC; HTL99016
RCB; RCB0508
Cell line databases/resources CLO; CLO_0003701
CLO; CLO_0051381
CLDB; cl1625
CLDB; cl4965
cancercelllines; CVCL_1238
Cell_Model_Passport; SIDM00535
Cosmic-CLP; 907290
DepMap; ACH-001519
LINCS_LDP; LCL-1458
Biological sample resources BioSample; SAMD00005690
BioSample; SAMN03472276
Chemistry resources ChEMBL-Cells; CHEMBL3308736
ChEMBL-Targets; CHEMBL1075451
GDSC; 907290
PharmacoDB; HEMCSS_419_2019
PubChem_Cell_line; CVCL_1238
Encyclopedic resources Wikidata; Q54871889
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
FANTOM5_SSTAR; 10410-106B5
GEO; GSM827448
GEO; GSM1669877
Polymorphism and mutation databases Cosmic; 907290
IARC_TP53; 21353
Progenetix; CVCL_1238
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number36