ID   H-EMC-SS
AC   CVCL_1238
SY   HEMCSS; HEMC-SS
DR   CLO; CLO_0003701
DR   CLO; CLO_0051381
DR   CLDB; cl1625
DR   CLDB; cl4965
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-3610
DR   BioSample; SAMD00005690
DR   BioSample; SAMN03472276
DR   cancercelllines; CVCL_1238
DR   Cell_Model_Passport; SIDM00535
DR   ChEMBL-Cells; CHEMBL3308736
DR   ChEMBL-Targets; CHEMBL1075451
DR   Cosmic; 907290
DR   Cosmic-CLP; 907290
DR   DepMap; ACH-001519
DR   ECACC; 94042258
DR   EGA; EGAS00001000978
DR   FANTOM5_SSTAR; 10410-106B5
DR   GDSC; 907290
DR   GEO; GSM827448
DR   GEO; GSM1669877
DR   IARC_TP53; 21353
DR   ICLC; HTL99016
DR   LINCS_LDP; LCL-1458
DR   PharmacoDB; HEMCSS_419_2019
DR   PRIDE; PXD030304
DR   Progenetix; CVCL_1238
DR   PubChem_Cell_line; CVCL_1238
DR   RCB; RCB0508
DR   Wikidata; Q54871889
RX   CelloPub=CLPUB00044;
RX   PubMed=20164919;
RX   PubMed=20215515;
RX   PubMed=27397505;
RX   PubMed=30894373;
RX   PubMed=34413129;
RX   PubMed=35839778;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Population: Japanese.
CC   Doubling time: 17.3-42.8 hours (CelloPub=CLPUB00044).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Omics: Genomics; DNA methylation analysis.
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Phenotyping; Drug screening.
CC   Omics: Proteomics; Quantitative.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Variations; SNP array analysis.
CC   Genome ancestry: African=0.61%; Native American=0.67%; East Asian, North=77.11%; East Asian, South=20.07%; South Asian=0.1%; European, North=0.01%; European, South=1.42% (PubMed=30894373).
CC   Caution: Does not harbor a gene fusion involving EWSR1 which is a hallmark of extraskeletal myxoid chondrosarcoma (PubMed=34413129).
CC   Derived from site: In situ; Muscle; UBERON=UBERON_0001630.
ST   Source(s): Cosmic-CLP=907290; DepMap=ACH-001519; RCB=RCB0508
ST   Amelogenin: X
ST   CSF1PO: 10,12
ST   D13S317: 9 (RCB=RCB0508)
ST   D13S317: 9,13 (Cosmic-CLP=907290; DepMap=ACH-001519)
ST   D16S539: 9,13
ST   D18S51: 16,24
ST   D21S11: 30,32.2
ST   D3S1358: 15,16
ST   D5S818: 10,12
ST   D7S820: 8,11
ST   D8S1179: 14,17
ST   FGA: 21,22
ST   Penta D: 9,10
ST   Penta E: 10,14
ST   TH01: 7,9
ST   TPOX: 8
ST   vWA: 14,17
DI   NCIt; C27502; Extraskeletal myxoid chondrosarcoma
DI   ORDO; Orphanet_209916; Extraskeletal myxoid chondrosarcoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   77Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 36
//
RX   CelloPub=CLPUB00044;
RA   Ooshima, Fumio
RT   "Establishment of a new cell line from human extraskeletal myxoid
RT   chondrosarcoma.";
RL   Dokkyo J. Med. Sci. 19:1-9(1992).
//
RX   PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775;
RA   Goncalves, Emanuel
RA   Poulos, Rebecca C.
RA   Cai, Zhao-Xiang
RA   Barthorpe, Syd
RA   Manda, Srikanth S.
RA   Lucas, Natasha
RA   Beck, Alexandra
RA   Bucio-Noble, Daniel
RA   Dausmann, Michael
RA   Hall, Caitlin
RA   Hecker, Michael
RA   Koh, Jennifer
RA   Lightfoot, Howard
RA   Mahboob, Sadia
RA   Mali, Iman
RA   Morris, James
RA   Richardson, Laura
RA   Seneviratne, Akila J.
RA   Shepherd, Rebecca
RA   Sykes, Erin
RA   Thomas, Frances
RA   Valentini, Sara
RA   Williams, Steven G.
RA   Wu, Yang-Xiu
RA   Xavier, Dylan
RA   MacKenzie, Karen L.
RA   Hains, Peter G.
RA   Tully, Brett
RA   Robinson, Phillip James
RA   Zhong, Qing
RA   Garnett, Mathew J.
RA   Reddel, Roger Robert
RT   "Pan-cancer proteomic map of 949 human cell lines.";
RL   Cancer Cell 40:835-849.e8(2022).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469;
RA   Iorio, Francesco
RA   Knijnenburg, Theo A.
RA   Vis, Daniel J.
RA   Bignell, Graham Robert
RA   Menden, Michael Patrick
RA   Schubert, Michael
RA   Aben, Nanne
RA   Goncalves, Emanuel
RA   Barthorpe, Syd
RA   Lightfoot, Howard
RA   Cokelaer, Thomas
RA   Greninger, Patricia
RA   van Dyk, Ewald
RA   Chang, Han
RA   de Silva, Heshani
RA   Heyn, Holger
RA   Deng, Xian-Ming
RA   Egan, Regina K.
RA   Liu, Qing-Song
RA   Mironenko, Tatiana
RA   Mitropoulos, Xeni
RA   Richardson, Laura
RA   Wang, Jin-Hua
RA   Zhang, Ting-Hu
RA   Moran, Sebastian
RA   Sayols, Sergi
RA   Soleimani, Maryam
RA   Tamborero, David
RA   Lopez-Bigas, Nuria
RA   Ross-Macdonald, Petra
RA   Esteller, Manel
RA   Gray, Nathanael S.
RA   Haber, Daniel Arie
RA   Stratton, Michael Rudolf
RA   Benes, Cyril Henri
RA   Wessels, Lodewyk F.A.
RA   Saez-Rodriguez, Julio
RA   McDermott, Ultan
RA   Garnett, Mathew J.
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=34413129; DOI=10.1158/1535-7163.MCT-21-0089; PMCID=PMC8571037;
RA   Gartrell, Jessica
RA   Mellado-Largarde, Marcia
RA   Clay, Michael R.
RA   Bahrami, Armita
RA   Sahr, Natasha A.
RA   Sykes, April D.
RA   Blankenship, Kaley
RA   Hoffmann, Lauren
RA   Xie, Jia
RA   Cho, Hyekyung P.
RA   Twarog, Nathaniel
RA   Connelly, Michele
RA   Yan, Koon-Kiu
RA   Yu, Ji-Yang
RA   Porter, Shaina N.
RA   Pruett-Miller, Shondra M.
RA   Neale, Geoffrey
RA   Tinkle, Christopher L.
RA   Federico, Sara M.
RA   Stewart, Elizabeth A.
RA   Shelat, Anang A.
RT   "SLFN11 is widely expressed in pediatric sarcoma and induces variable
RT   sensitization to replicative stress caused by DNA-damaging agents.";
RL   Mol. Cancer Ther. 20:2151-2165(2021).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113;
RA   Bignell, Graham Robert
RA   Greenman, Christopher D.
RA   Davies, Helen R.
RA   Butler, Adam P.
RA   Edkins, Sarah
RA   Andrews, Jenny M.
RA   Buck, Gemma
RA   Chen, Lina
RA   Beare, David
RA   Latimer, Calli
RA   Widaa, Sara
RA   Hinton, Jonathan
RA   Fahey, Ciara
RA   Fu, Bei-Yuan
RA   Swamy, Sajani
RA   Dalgliesh, Gillian L.
RA   Teh, Bin Tean
RA   Deloukas, Panos
RA   Yang, Feng-Tang
RA   Campbell, Peter J.
RA   Futreal, P. Andrew
RA   Stratton, Michael Rudolf
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662;
RA   Rothenberg, S. Michael
RA   Mohapatra, Gayatry
RA   Rivera, Miguel N.
RA   Winokur, Daniel
RA   Greninger, Patricia
RA   Nitta, Mai
RA   Sadow, Peter M.
RA   Sooriyakumar, Gaya
RA   Brannigan, Brian W.
RA   Ulman, Matthew J.
RA   Perera, Rushika M.
RA   Wang, Rui
RA   Tam, Angela
RA   Ma, Xiao-Jun
RA   Erlander, Mark
RA   Sgroi, Dennis C.
RA   Rocco, James W.
RA   Lingen, Mark W.
RA   Cohen, Ezra E.W.
RA   Louis, David Neil
RA   Settleman, Jeffrey
RA   Haber, Daniel Arie
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//