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Cellosaurus BALL-1 (CVCL_1075)

[Text version]
Cell line name BALL-1
Synonyms Ball-1; Ball 1; BALL1; B-cell Acute Lymphoblastic Leukemia-1
Accession CVCL_1075
Resource Identification Initiative To cite this cell line use: BALL-1 (RRID:CVCL_1075)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: MD Anderson Cell Lines Project.
Population: Japanese.
Doubling time: 80 hours (Note=In RPMI 1640 + 20% HCS), 66 hours (Note=In RPMI 1640 + 20% FCS) (PubMed=195075); ~48-72 hours (DSMZ=ACC-742).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: B-cell; CL=CL_0000236.
Sequence variations
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0
East Asian, North81.09
East Asian, South18.9
South Asian0
European, North0
European, South0
Disease Adult B acute lymphoblastic leukemia (NCIt: C9143)
Precursor B-cell acute lymphoblastic leukemia (ORDO: Orphanet_99860)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_A8V6 (BALL-1/CD20-KO)CVCL_U321 (JDB1)
Sex of cell Male
Age at sampling 75Y
Category Cancer cell line
STR profile Source(s): CCRID=5301HUM-KCB94007YJ; Cosmic-CLP=910705; DSMZ=ACC-742; JCRB=JCRB0071; RCB=RCB0256; TKG=TKG 0467

Markers:
AmelogeninX (JCRB=JCRB0071; TKG=TKG 0467)
X,Y (CCRID=5301HUM-KCB94007YJ; Cosmic-CLP=910705; DSMZ=ACC-742; RCB=RCB0256)
CSF1PO10,12
D2S133819,22
D3S135816
D5S81810,12,13 (RCB=RCB0256)
10,13 (CCRID=5301HUM-KCB94007YJ; Cosmic-CLP=910705; DSMZ=ACC-742; JCRB=JCRB0071; TKG=TKG 0467)
D7S82010,12
D8S117910,14
D13S3179,12
D16S5399
D18S5112,13 (CCRID=5301HUM-KCB94007YJ)
13 (DSMZ=ACC-742)
D19S43313,15.2 (CCRID=5301HUM-KCB94007YJ)
13,16 (DSMZ=ACC-742)
D21S1130
FGA22,23
Penta D9,10
Penta E14,16
TH017,9
TPOX8,11
vWA14,18

Run an STR similarity search on this cell line
Web pages Info; MCLP; -; https://tcpaportal.org/mclp/
Publications

PubMed=195075; DOI=10.1093/jnci/59.1.93
Shunkichi Hiraki, Isao Miyoshi, Hiroshi Masuji, Ichiro Kubonishi, Yuzo Matsuda;
Establishment of an Epstein-Barr virus-determined nuclear antigen-negative human B-cell line from acute lymphoblastic leukemia.
J. Natl. Cancer Inst. 59:93-94(1977)

PubMed=197412; DOI=10.1038/267843a0
Isao Miyoshi, Shunkichi Hiraki, Teruhiko Tsubota, Ichiro Kubonishi, Yuzo Matsuda, Takashi Nakayama, Hirofumi Kishimoto, Ikuro Kimura, Hiroshi Masuji;
Human B cell, T cell and null cell leukaemic cell lines derived from acute lymphoblastic leukaemias.
Nature 267:843-844(1977)

DOI=10.4044/joma1947.92.5-6_763
Kazuo Nakamura;
Studies on human leukemic B-cell line, Part I. Establishment and characterization of human leukemic B-cell line (BALL-1).
Okayama Igakkai Zasshi 92:763-773(1980)

PubMed=6582512; DOI=10.1073/pnas.81.2.568; PMCID=PMC344720
Michael Jules Mattes, Carlos Cordon-Cardo, John L. Lewis Jr., Lloyd John Old, Kenneth Oliver Lloyd;
Cell surface antigens of human ovarian and endometrial carcinoma defined by mouse monoclonal antibodies.
Proc. Natl. Acad. Sci. U.S.A. 81:568-572(1984)

PubMed=2985879; DOI=10.1016/0145-2126(85)90084-0
Hans Gunther Drexler, Gerhard Gaedicke, Jun Minowada;
Isoenzyme studies in human leukemia-lymphoma cell lines -- 1 Carboxylic esterase.
Leuk. Res. 9:209-229(1985)

PubMed=3159941; DOI=10.1016/0145-2126(85)90134-1
Hans Gunther Drexler, Gerhard Gaedicke, Jun Minowada;
Isoenzyme studies in human leukemia-lymphoma cell lines -- III Beta-hexosaminidase (E.C. 3.2.1.30).
Leuk. Res. 9:549-559(1985)

PubMed=3874327; DOI=10.1016/0145-2126(85)90133-x
Hans Gunther Drexler, Gerhard Gaedicke, Jun Minowada;
Isoenzyme studies in human leukemia-lymphoma cells lines -- II. Acid phosphatase.
Leuk. Res. 9:537-548(1985)

PubMed=8139288; DOI=10.1016/0145-2126(94)90118-x
Seitetsu Sato, Yoshio Honma, Motoo Hozumi, Yasuhide Hayashi, Yoshinobu Matsuo, Kiyoshi Shibata, Satoshi Omura, Ken-ichiro Hino, Shigeru Tomoyasu, Nobuyoshi Tsuruoka;
Effects of herbimycin A and its derivatives on growth and differentiation of Ph1-positive acute lymphoid leukemia cell lines.
Leuk. Res. 18:221-228(1994)

PubMed=8156010; DOI=10.1159/000236736
Naoko Yoshida, Mika Ueno, Naoki Saita, Mitsuomi Hirashima;
A B cell lymphoma line, BALL-1 stimulates T cells to produce a unique eosinophil chemotactic factor.
Int. Arch. Allergy Immunol. 104 Suppl. 1:9-11(1994)

DOI=10.11418/jtca1981.15.4_211
Yoshinobu Matsuo, Ayumi Okochi, Toshio Ariyasu, Emi Iimura, Tadao Ohno;
Identification of cell lines with variable numbers of tandem repeat (VNTR) amplified by polymerase chain reaction.
Tissue Cult. Res. Commun. 15:211-219(1996)

PubMed=8957066; DOI=10.1111/j.1349-7006.1996.tb03112.x; PMCID=PMC5920998
Nobuhiro Kawasaki, Yoshinobu Matsuo, Tadashi Yoshino, Hiroyuki Yanai, Takashi Oka, Norihiro Teramoto, Cao Liu, Eisaku Kondo, Jun Minowada, Tadaatsu Akagi;
Metastatic potential of lymphoma/leukemia cell lines in SCID mice is closely related to expression of CD44.
Jpn. J. Cancer Res. 87:1070-1077(1996)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Li-Qun Jia, Motonobu Osada, Chikashi Ishioka, Makio Gamo, Shuntaro Ikawa, Takao Suzuki, Hideki Shimodaira, Tomohito Niitani, Toshio Kudo, Mitoshi Akiyama, Narimiti Kimura ...Show all 18 authors... , Mitsuyoshi Matsuo, Hiroshi Mizusawa, Noriho Tanaka, Hideki Koyama, Masayoshi Namba, Ryunosuke Kanamaru, Toshio Kuroki; Show fewer authors
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

PubMed=9510473; DOI=10.1111/j.1349-7006.1998.tb00476.x; PMCID=PMC5921588
Noriko Hosoya, Akira Hangaishi, Seishi Ogawa, Kiyoshi Miyagawa, Kinuko Mitani, Yoshio Yazaki, Hisamaru Hirai;
Frameshift mutations of the hMSH6 gene in human leukemia cell lines.
Jpn. J. Cancer Res. 89:33-39(1998)

DOI=10.1016/B978-0-12-221970-2.50457-5
Hans Gunther Drexler;
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=15901131; DOI=10.1016/j.prp.2005.01.002
Yoshihiro Murai, Shinichi Hayashi, Hiroyuki Takahashi, Koichi Tsuneyama, Yasuo Takano;
Correlation between DNA alterations and p53 and p16 protein expression in cancer cell lines.
Pathol. Res. Pract. 201:109-115(2005)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) CLS; 305084
DSMZ; ACC-742
JCRB; JCRB0071
KCB; KCB 94007YJ
RCB; RCB0256
RCB; RCB1882
TKG; TKG 0467
Cell line databases/resources CLO; CLO_0037300
CLO; CLO_0051004
CLO; CLO_0051005
cancercelllines; CVCL_1075
CCRID; 5301HUM-KCB94007YJ
Cell_Model_Passport; SIDM00287
Cosmic-CLP; 910705
DepMap; ACH-002211
DSMZCellDive; ACC-742
LINCS_LDP; LCL-1005
Anatomy/cell type resources BTO; BTO_0001148
Biological sample resources BioSample; SAMN03471059
BioSample; SAMN03472350
Chemistry resources ChEMBL-Cells; CHEMBL3308839
ChEMBL-Targets; CHEMBL2366269
GDSC; 910705
PharmacoDB; BALL1_73_2019
PubChem_Cell_line; CVCL_1075
Encyclopedic resources Wikidata; Q54753112
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
FANTOM5_SSTAR; 10455-106G5
GEO; GSM827223
GEO; GSM1669606
Polymorphism and mutation databases Cosmic; 910705
Cosmic; 919134
Cosmic; 999755
Cosmic; 999762
Cosmic; 1150902
IARC_TP53; 21184
Progenetix; CVCL_1075
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number42