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Cellosaurus B-THP-1 (CVCL_0R19)

[Text version]
Cell line name B-THP-1
Accession CVCL_0R19
Resource Identification Initiative To cite this cell line use: B-THP-1 (RRID:CVCL_0R19)
Comments Problematic cell line: Misidentified. Originally thought to be THP-1 (PubMed=10721995) but later shown to be a derivative of Raji (PubMed=14972530).
Population: African; Nigerian.
Doubling time: ~20 hours (BEI_Resources=ARP-9940).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Derived from site: In situ; Bone, jaw, maxilla; UBERON=UBERON_0002397.
Cell type: B-cell; CL=CL_0000236.
Sequence variations
  • Gene fusion; HGNC; HGNC:5477; IGH + HGNC; HGNC:7553; MYC; Name(s)=MYC-IGH (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg213Gln (c.638G>A); ClinVar=VCV000135359; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr234His (c.700T>C); ClinVar=VCV000376691; Zygosity=Heterozygous (from parent cell line).
Disease EBV-related Burkitt lymphoma (NCIt: C27694)
Burkitt lymphoma (ORDO: Orphanet_543)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0511 (Raji)
Children:
CVCL_0R20 (B-THP-1/DC-SIGN)
Sex of cell Male
Age at sampling 11Y
Category Cancer cell line
Publications

PubMed=10721995; DOI=10.1016/S0092-8674(00)80694-7
Teunis B.H. Geijtenbeek, Douglas S. Kwon, Ruurd Torensma, Sandra Johanna van Vliet, Gerard C.F. van Duijnhoven, Jeena Middel, Ine L.M.H.A. Cornelissen, Hans S.L.M. Nottet, Vineet N. KewalRamani, Dan Rudolf Littman, Carl Gustav Figdor, Yvette van Kooyk;
DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells.
Cell 100:587-597(2000)

PubMed=14972530; DOI=10.1016/j.virol.2003.09.028
Li Wu, Thomas D. Martin, Mary N. Carrington, Vineet N. KewalRamani;
Raji B cells, misidentified as THP-1 cells, stimulate DC-SIGN-mediated HIV transmission.
Virology 318:17-23(2004)

Cross-references
Cell line collections (Providers) BEI_Resources; ARP-9940
Cell line databases/resources cancercelllines; CVCL_0R19
Encyclopedic resources Wikidata; Q54752139
Entry history
Entry creation08-Jul-2015
Last entry update19-Dec-2024
Version number21