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Cellosaurus A2EN (CVCL_0P36)

[Text version]
Cell line name A2EN
Synonyms DT-21
Accession CVCL_0P36
Resource Identification Initiative To cite this cell line use: A2EN (RRID:CVCL_0P36)
Comments Characteristics: Established as a model for sexually transmitted pathogens infection, pathogenesis and innate immune response studies (Kerafast=ELU101).
Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Derived from site: In situ; Uterus, cervix, endocervical epithelium; UBERON=UBERON_0012252.
Cell type: Epithelial cell; CL=CL_0000066.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 55Y
Category Transformed cell line
STR profile Source(s): Millipore=SCC131

Markers:
AmelogeninX
CSF1PO12,13
D3S135815
D5S81811,13
D7S82011
D8S117912,16
D13S3179,13
D16S5399,11
D18S5114,18
D21S1129,32.2
FGA21
Penta D9,12
Penta E7,10
TH016
TPOX8,11
vWA17

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Publications

PubMed=18201283; DOI=10.1111/j.1600-0897.2007.00566.x
Melissa M. Herbst-Kralovetz, Alison Jane Quayle, Mercedes Ficarra, Sheila J. Greene, William A. Rose 2nd, Ralph Chesson, Rae Ann Spagnuolo, Richard B. Pyles;
Quantification and comparison of Toll-like receptor expression and responsiveness in primary and immortalized human female lower genital tract epithelia.
Am. J. Reprod. Immunol. 59:212-224(2008)

PubMed=21943934; DOI=10.1016/j.jri.2011.08.002; PMCID=PMC3894833
Lyndsey R. Buckner, Danny J. Schust, Jian Ding, Takeshi Nagamatsu, Wandy Beatty, Theresa Li-Yun Chang, Sheila J. Greene, Maria E. Lewis, Bernardo Ruiz, Stacey L. Holman, Rae Ann Spagnuolo ...Show all 13 authors... , Richard B. Pyles, Alison Jane Quayle; Show fewer authors
Innate immune mediator profiles and their regulation in a novel polarized immortalized epithelial cell model derived from human endocervix.
J. Reprod. Immunol. 92:8-20(2011)

Cross-references
Cell line collections (Providers) ABM; T0595
CancerTools; 157949
Kerafast; ELU101
Millipore; SCC131
Encyclopedic resources Wikidata; Q54606622
Entry history
Entry creation10-Apr-2015
Last entry update14-Aug-2025
Version number20