ID   A2EN
AC   CVCL_0P36
SY   DT-21
DR   ABM; T0595
DR   CancerTools; 157949
DR   Kerafast; ELU101
DR   Millipore; SCC131
DR   Wikidata; Q54606622
RX   PubMed=18201283;
RX   PubMed=21943934;
CC   Characteristics: Established as a model for sexually transmitted pathogens infection, pathogenesis and innate immune response studies (Kerafast=ELU101).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
CC   Derived from site: In situ; Uterus, cervix, endocervical epithelium; UBERON=UBERON_0012252.
CC   Cell type: Epithelial cell; CL=CL_0000066.
ST   Source(s): Millipore=SCC131
ST   Amelogenin: X
ST   CSF1PO: 12,13
ST   D13S317: 9,13
ST   D16S539: 9,11
ST   D18S51: 14,18
ST   D21S11: 29,32.2
ST   D3S1358: 15
ST   D5S818: 11,13
ST   D7S820: 11
ST   D8S1179: 12,16
ST   FGA: 21
ST   Penta D: 9,12
ST   Penta E: 7,10
ST   TH01: 6
ST   TPOX: 8,11
ST   vWA: 17
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   55Y
CA   Transformed cell line
DT   Created: 10-04-15; Last updated: 10-04-25; Version: 19
//
RX   PubMed=18201283; DOI=10.1111/j.1600-0897.2007.00566.x;
RA   Herbst-Kralovetz M.M., Quayle A.J., Ficarra M., Greene S.J.,
RA   Rose W.A. 2nd, Chesson R., Spagnuolo R.A., Pyles R.B.;
RT   "Quantification and comparison of Toll-like receptor expression and
RT   responsiveness in primary and immortalized human female lower genital
RT   tract epithelia.";
RL   Am. J. Reprod. Immunol. 59:212-224(2008).
//
RX   PubMed=21943934; DOI=10.1016/j.jri.2011.08.002; PMCID=PMC3894833;
RA   Buckner L.R., Schust D.J., Ding J., Nagamatsu T., Beatty W.,
RA   Chang T.L.-Y., Greene S.J., Lewis M.E., Ruiz B., Holman S.L.,
RA   Spagnuolo R.A., Pyles R.B., Quayle A.J.;
RT   "Innate immune mediator profiles and their regulation in a novel
RT   polarized immortalized epithelial cell model derived from human
RT   endocervix.";
RL   J. Reprod. Immunol. 92:8-20(2011).
//