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Cellosaurus MLO-A5 (CVCL_0P24)

[Text version]
Cell line name MLO-A5
Synonyms MLOA5; Murine Long bone Osteocyte-A5
Accession CVCL_0P24
Resource Identification Initiative To cite this cell line use: MLO-A5 (RRID:CVCL_0P24)
Comments Characteristics: Model for the osteoblast to osteocyte differentiation process, the mineralization process and the effects of mechanical loading on biomineralization (Kerafast=EKC003).
Genetic integration: Method=Transgenic mouse; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Derived from site: In situ; Bone, long bone; UBERON=UBERON_0002495.
Cell type: Osteocyte; CL=CL_0000137.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: (C57BL/6J x BALB/cJ) F2 Bgla promoter T-Ag transgenic.
Sex of cell Sex unspecified
Age at sampling 14D
Category Transformed cell line
Publications

PubMed=11547831; DOI=10.1359/jbmr.2001.16.9.1622
Y. Kato, Adele L. Boskey, Lyudmila Spevak, Mark Dallas, M. Hori, Lynda Faye Bonewald;
Establishment of an osteoid preosteocyte-like cell MLO-A5 that spontaneously mineralizes in culture.
J. Bone Miner. Res. 16:1622-1633(2001)

PubMed=16738320; DOI=10.1128/mcb.02120-05; PMCID=PMC1489126
Ke-Qin Zhang, Cielo Barragan-Adjemian, Ling Ye, Shiva Kotha, Mark Dallas, Yong-Bo Lu, Shu-Jie Zhao, Marie Harris, Stephen E. Harris, Jian Q. Feng, Lynda Faye Bonewald;
E11/gp38 selective expression in osteocytes: regulation by mechanical strain and role in dendrite elongation.
Mol. Cell. Biol. 26:4539-4552(2006)

PubMed=22130923; DOI=10.1007/978-1-61779-415-5_6
Jennifer Rosser, Lynda Faye Bonewald;
Studying osteocyte function using the cell lines MLO-Y4 and MLO-A5.
Methods Mol. Biol. 816:67-81(2012)

Cross-references
Cell line collections (Providers) Kerafast; EKC003
Encyclopedic resources Wikidata; Q54905977
Entry history
Entry creation10-Apr-2015
Last entry update14-Aug-2025
Version number14