ID   MLO-A5
AC   CVCL_0P24
SY   MLOA5; Murine Long bone Osteocyte-A5
DR   Kerafast; EKC003
DR   Wikidata; Q54905977
RX   PubMed=11547831;
RX   PubMed=16738320;
RX   PubMed=22130923;
CC   Characteristics: Model for the osteoblast to osteocyte differentiation process, the mineralization process and the effects of mechanical loading on biomineralization (Kerafast=EKC003).
CC   Genetic integration: Method=Transgenic mouse; Gene=UniProtKB; P03070; SV40 large T antigen.
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
CC   Derived from site: In situ; Bone, long bone; UBERON=UBERON_0002495.
CC   Cell type: Osteocyte; CL=CL_0000137.
CC   Breed/subspecies: (C57BL/6J x BALB/cJ) F2 Bgla promoter T-Ag transgenic.
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
SX   Sex unspecified
AG   14D
CA   Transformed cell line
DT   Created: 10-04-15; Last updated: 10-09-24; Version: 13
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RX   PubMed=11547831; DOI=10.1359/jbmr.2001.16.9.1622;
RA   Kato Y., Boskey A.L., Spevak L., Dallas M., Hori M., Bonewald L.F.;
RT   "Establishment of an osteoid preosteocyte-like cell MLO-A5 that
RT   spontaneously mineralizes in culture.";
RL   J. Bone Miner. Res. 16:1622-1633(2001).
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RX   PubMed=16738320; DOI=10.1128/mcb.02120-05; PMCID=PMC1489126;
RA   Zhang K.-Q., Barragan-Adjemian C., Ye L., Kotha S., Dallas M.,
RA   Lu Y.-B., Zhao S.-J., Harris M., Harris S.E., Feng J.Q., Bonewald L.F.;
RT   "E11/gp38 selective expression in osteocytes: regulation by mechanical
RT   strain and role in dendrite elongation.";
RL   Mol. Cell. Biol. 26:4539-4552(2006).
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RX   PubMed=22130923; DOI=10.1007/978-1-61779-415-5_6;
RA   Rosser J., Bonewald L.F.;
RT   "Studying osteocyte function using the cell lines MLO-Y4 and MLO-A5.";
RL   Methods Mol. Biol. 816:67-81(2012).
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