| Cell line name |
S1-M1-3.2 |
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| Accession |
CVCL_0H86 |
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| Resource Identification Initiative |
To cite this cell line use: S1-M1-3.2 (RRID:CVCL_0H86) |
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| Comments |
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_50729; Mitoxantrone.
Derived from site: In situ; Colon; UBERON=UBERON_0001155. |
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| Sequence variations |
- Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Ser45Phe (c.134C>T); ClinVar=VCV000017588; Zygosity=Unspecified (from parent cell line).
- Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Unspecified (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Unspecified (from parent cell line).
|
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| Disease |
Colon adenocarcinoma (NCIt: C4349) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0H88 (S1)
Children:
|
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| Sex of cell |
Female |
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| Age at sampling |
58Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=9865745
Sridhar K. Rabindran, Hai-Yin He, Maya Singh, Eileen Brown, Karen I. Collins, Tami Annable, Lee M. Greenberger;
Reversal of a novel multidrug resistance mechanism in human colon carcinoma cells by fumitremorgin C.
Cancer Res. 58:5850-5858(1998) PubMed=11406094; DOI=10.1016/S0005-2736(01)00308-X
Robert W. Robey, Yasumasa Honjo, Anne van de Laar, Keisuke Miyake, Joanna T. Regis, Thomas Litman, Susan E. Bates;
A functional assay for detection of the mitoxantrone resistance protein, MXR (ABCG2).
Biochim. Biophys. Acta 1512:171-182(2001) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_0H86
|
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| Encyclopedic resources |
Wikidata; Q54951789
|
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| Entry history |
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| Entry creation | 10-Apr-2015 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 14 |
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