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Cellosaurus HMEEC-1 (CVCL_0E44)

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Cell line name HMEEC-1
Synonyms HEI-HMEEC-1; HEI-HMEEC; Human Middle Ear Epithelial Cell line-1
Accession CVCL_0E44
Resource Identification Initiative To cite this cell line use: HMEEC-1 (RRID:CVCL_0E44)
Comments Group: Patented cell line.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); PTA-81.
Doubling time: 23.8 hours (PubMed=12090706).
Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Derived from site: In situ; Ear, middle ear; UBERON=UBERON_0001756.
Cell type: Epithelial cell; CL=CL_0000066.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling Age unspecified
Category Transformed cell line
STR profile Source(s): ATCC=CRL-13012

Markers:
AmelogeninX,Y
CSF1PO11
D5S81810,13
D7S82010,11
D13S31710,11
D16S53912,13
TH016,7
TPOX9,11
vWA16,17

Run an STR similarity search on this cell line
Publications

Patent=US6358688
David J. Lim, Young-Myoung Chun, Johng Sik Rhim;
Immortalized human middle ear epithelial cell lines.
Patent number US6358688, 19-Mar-2002

PubMed=12090706; DOI=10.1177/000348940211100606
Young-Myoung Chun, Sung-Kyun Moon, Haa-Yung Lee, Paul Webster, Derald Elmer Brackmann, Johng Sik Rhim, David J. Lim;
Immortalization of normal adult human middle ear epithelial cells using a retrovirus containing the E6/E7 genes of human papillomavirus type 16.
Ann. Otol. Rhinol. Laryngol. 111:507-517(2002)

PubMed=21901615; DOI=10.1007/978-1-4614-0254-1_2
David J. Lim, Sung-Kyun Moon;
Establishment of cell lines from the human middle and inner ear epithelial cells.
Adv. Exp. Med. Biol. 720:15-25(2011)

PubMed=32433794; DOI=10.1002/lary.28687
Mana Espahbodi, Tina L. Samuels, Caroline McCormick, Pawjai Khampang, Ke Yan, Samuel Marshall, Michael E. McCormick, Robert H. Chun, Steven A. Harvey, David Richard Friedland, Nikki Johnston, Joseph E. Kerschner;
Analysis of inflammatory signaling in human middle ear cell culture models of pediatric otitis media.
Laryngoscope 131:410-416(2021)

Cross-references
Cell line collections (Providers) ATCC; CRL-13012 - Discontinued
Biological sample resources BioSample; SAMN03471351
Encyclopedic resources Wikidata; Q54889922
Entry history
Entry creation10-Apr-2015
Last entry update14-Aug-2025
Version number16