ID   HMEEC-1
AC   CVCL_0E44
SY   HEI-HMEEC-1; HEI-HMEEC; Human Middle Ear Epithelial Cell line-1
DR   ATCC; CRL-13012
DR   BioSample; SAMN03471351
DR   Wikidata; Q54889922
RX   Patent=US6358688;
RX   PubMed=12090706;
RX   PubMed=21901615;
CC   Group: Patented cell line.
CC   Registration: International Depositary Authority, American Type Culture Collection (ATCC); PTA-81.
CC   Doubling time: 23.8 hours (PubMed=12090706).
CC   Transfected with: UniProtKB; P03126; Human papillomavirus type 16 protein E6.
CC   Transfected with: UniProtKB; P03129; Human papillomavirus type 16 protein E7.
CC   Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
CC   Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
CC   Discontinued: ATCC; CRL-13012; true.
CC   Derived from site: In situ; Ear, middle ear; UBERON=UBERON_0001756.
CC   Cell type: Epithelial cell; CL=CL_0000066.
ST   Source(s): ATCC=CRL-13012
ST   Amelogenin: X,Y
ST   CSF1PO: 11
ST   D13S317: 10,11
ST   D16S539: 12,13
ST   D5S818: 10,13
ST   D7S820: 10,11
ST   TH01: 6,7
ST   TPOX: 9,11
ST   vWA: 16,17
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   Age unspecified
CA   Transformed cell line
DT   Created: 10-04-15; Last updated: 02-05-24; Version: 13
//
RX   Patent=US6358688;
RA   Lim D.J., Chun Y.-M., Rhim J.S.;
RT   "Immortalized human middle ear epithelial cell lines.";
RL   Patent number US6358688, 19-Mar-2002.
//
RX   PubMed=12090706; DOI=10.1177/000348940211100606;
RA   Chun Y.-M., Moon S.-K., Lee H.-Y., Webster P., Brackmann D.E.,
RA   Rhim J.S., Lim D.J.;
RT   "Immortalization of normal adult human middle ear epithelial cells
RT   using a retrovirus containing the E6/E7 genes of human papillomavirus
RT   type 16.";
RL   Ann. Otol. Rhinol. Laryngol. 111:507-517(2002).
//
RX   PubMed=21901615; DOI=10.1007/978-1-4614-0254-1_2;
RA   Lim D.J., Moon S.-K.;
RT   "Establishment of cell lines from the human middle and inner ear
RT   epithelial cells.";
RL   Adv. Exp. Med. Biol. 720:15-25(2011).
//