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Cellosaurus MV522/MRP (CVCL_0E38)

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Cell line name MV522/MRP
Accession CVCL_0E38
Resource Identification Initiative To cite this cell line use: MV522/MRP (RRID:CVCL_0E38)
Comments Problematic cell line: Contaminated. Parent cell line (MV-522) has been shown to be a HT-29 derivative.
Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:51; ABCC1.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations
  • Mutation; HGNC; HGNC:583; APC; Simple; p.Glu853Ter (c.2557G>T); ClinVar=VCV001071632; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:583; APC; Simple; p.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA); ClinVar=VCV000428112; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Pro449Thr (c.1345C>A); ClinVar=VCV001333250; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6770; SMAD4; Simple; p.Gln311Ter (c.931C>T); ClinVar=VCV000230663; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_7204 (MV-522)
Sex of cell Female
Age at sampling 44Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-2521

Markers:
AmelogeninX
CSF1PO12
D5S81811,12
D7S82010
D13S31711,12
D16S53911,12
TH016
TPOX8,9
vWA17,19

Run an STR similarity search on this cell line
Publications

PubMed=10831281; DOI=10.1097/00001813-200003000-00010
Michael J. Kelner, Trevor C. McMorris, Leita A. Estes, Michelle Y. Oval, Rafael J. Rojas, Joshua R. Lynn, Kevin A. Lanham, Kyra M. Samson;
Efficacy of MGI 114 (HMAF) against the MRP+ metastatic MV522 lung carcinoma xenograft.
Anticancer Drugs 11:217-224(2000)

Cross-references
Cell line collections (Providers) ATCC; CRL-2521 - Discontinued
Cell line databases/resources cancercelllines; CVCL_0E38
Biological sample resources BioSample; SAMN03471605
Encyclopedic resources Wikidata; Q54907111
Entry history
Entry creation10-Apr-2015
Last entry update14-Aug-2025
Version number24