ID   MV522/MRP
AC   CVCL_0E38
DR   ATCC; CRL-2521
DR   BioSample; SAMN03471605
DR   cancercelllines; CVCL_0E38
DR   Wikidata; Q54907111
RX   PubMed=10831281;
CC   Problematic cell line: Contaminated. Parent cell line (MV-522) has been shown to be a HT-29 derivative.
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; HGNC:583; APC; Simple; p.Glu853Ter (c.2557G>T); ClinVar=VCV001071632; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:583; APC; Simple; p.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA); ClinVar=VCV000428112; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Pro449Thr (c.1345C>A); ClinVar=VCV001333250; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:6770; SMAD4; Simple; p.Gln311Ter (c.931C>T); ClinVar=VCV000230663; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
CC   Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:51; ABCC1.
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
CC   Discontinued: ATCC; CRL-2521; true.
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
ST   Source(s): ATCC=CRL-2521
ST   Amelogenin: X
ST   CSF1PO: 12
ST   D13S317: 11,12
ST   D16S539: 11,12
ST   D5S818: 11,12
ST   D7S820: 10
ST   TH01: 6
ST   TPOX: 8,9
ST   vWA: 17,19
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_7204 ! MV-522
SX   Female
AG   44Y
CA   Cancer cell line
DT   Created: 10-04-15; Last updated: 14-08-25; Version: 24
//
RX   PubMed=10831281; DOI=10.1097/00001813-200003000-00010;
RA   Kelner, Michael J.
RA   McMorris, Trevor C.
RA   Estes, Leita A.
RA   Oval, Michelle Y.
RA   Rojas, Rafael J.
RA   Lynn, Joshua R.
RA   Lanham, Kevin A.
RA   Samson, Kyra M.
RT   "Efficacy of MGI 114 (HMAF) against the MRP+ metastatic MV522 lung
RT   carcinoma xenograft.";
RL   Anticancer Drugs 11:217-224(2000).
//