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Cellosaurus CML-10C2 (CVCL_0D25)

[Text version]
Cell line name CML-10C2
Synonyms CML-10c2; CML_10C2; CML10C2
Accession CVCL_0D25
Resource Identification Initiative To cite this cell line use: CML-10C2 (RRID:CVCL_0D25)
Comments Part of: FACC canine tumor cell line panel.
Doubling time: 21 hours (PubMed=27257868).
Omics: Deep exome analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000027.
Sequence variations
  • Mutation; VGNC; 42508; KRAS; Simple; p.Gly12Val (c.35G>T); Zygosity=Heterozygous (PubMed=31175136).
Disease Canine oral melanoma (NCIt: C185639)
Species of origin Canis lupus familiaris (Dog) (Canis familiaris) (NCBI Taxonomy: 9615)
Hierarchy Parent: CVCL_IZ11 (CML-10)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): PubMed=27197945; PubMed=31175136

Markers:
Dog FHC2010231
Dog FHC2054156
Dog FHC2079271,291
Dog PEZ1123
Dog PEZ12270,274
Dog PEZ20176
Dog PEZ3119
Dog PEZ5115
Dog PEZ6179,183
Dog PEZ8228,240

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Publications

PubMed=21908323; DOI=10.1177/1040638711408064
O'Donoghue L.E., Rivest J.P., Duval D.L.
Polymerase chain reaction-based species verification and microsatellite analysis for canine cell line validation.
J. Vet. Diagn. Invest. 23:780-785(2011)

PubMed=22901430; DOI=10.1016/j.jcpa.2012.07.001
Chon E., Thompson V., Schmid S., Stein T.J.
Activation of the canonical Wnt/beta-catenin signalling pathway is rare in canine malignant melanoma tissue and cell lines.
J. Comp. Pathol. 148:178-187(2013)

PubMed=27257868; DOI=10.1371/journal.pone.0156689
Maeda J., Froning C.E., Brents C.A., Rose B.J., Thamm D.H., Kato T.A.
Intrinsic radiosensitivity and cellular characterization of 27 canine cancer cell lines.
PLoS ONE 11:E0156689-E0156689(2016)

PubMed=27197945; DOI=10.1111/vco.12192
Fowles J.S., Dailey D.D., Gustafson D.L., Thamm D.H., Duval D.L.
The Flint Animal Cancer Center (FACC) canine tumour cell line panel: a resource for veterinary drug discovery, comparative oncology and translational medicine.
Vet. Comp. Oncol. 15:481-492(2017)

PubMed=31175136; DOI=10.1158/1535-7163.MCT-18-1346
Das S., Idate R., Cronise K.E., Gustafson D.L., Duval D.L.
Identifying candidate druggable targets in canine cancer cell lines using whole exome sequencing.
Mol. Cancer Ther. 18:1460-1471(2019)

Cross-references
Encyclopedic resources Wikidata; Q54813783
Gene expression databases GEO; GSM1974781
Entry history
Entry creation10-Apr-2015
Last entry update29-Jun-2023
Version number15