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Cellosaurus CML-10C2 (CVCL_0D25)

[Text version]
Cell line name CML-10C2
Synonyms CML-10c2; CML_10C2; CML10C2
Accession CVCL_0D25
Resource Identification Initiative To cite this cell line use: CML-10C2 (RRID:CVCL_0D25)
Comments Part of: FACC canine tumor cell line panel.
Doubling time: 21 hours (PubMed=27257868).
Omics: Deep exome analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000027.
Sequence variations
  • Mutation; VGNC; 42508; KRAS; Simple; p.Gly12Val (c.35G>T); Zygosity=Heterozygous (PubMed=31175136).
Disease Canine oral melanoma (NCIt: C185639)
Species of origin Canis lupus familiaris (Dog) (Canis familiaris) (NCBI Taxonomy: 9615)
Hierarchy Parent: CVCL_IZ11 (CML-10)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): PubMed=27197945; PubMed=31175136

Dog FHC2010231
Dog FHC2054156
Dog FHC2079271,291
Dog PEZ1123
Dog PEZ12270,274
Dog PEZ20176
Dog PEZ3119
Dog PEZ5115
Dog PEZ6179,183
Dog PEZ8228,240

Run an STR similarity search on this cell line

PubMed=21908323; DOI=10.1177/1040638711408064
O'Donoghue L.E., Rivest J.P., Duval D.L.
Polymerase chain reaction-based species verification and microsatellite analysis for canine cell line validation.
J. Vet. Diagn. Invest. 23:780-785(2011)

PubMed=22901430; DOI=10.1016/j.jcpa.2012.07.001
Chon E., Thompson V., Schmid S., Stein T.J.
Activation of the canonical Wnt/beta-catenin signalling pathway is rare in canine malignant melanoma tissue and cell lines.
J. Comp. Pathol. 148:178-187(2013)

PubMed=27257868; DOI=10.1371/journal.pone.0156689
Maeda J., Froning C.E., Brents C.A., Rose B.J., Thamm D.H., Kato T.A.
Intrinsic radiosensitivity and cellular characterization of 27 canine cancer cell lines.
PLoS ONE 11:E0156689-E0156689(2016)

PubMed=27197945; DOI=10.1111/vco.12192
Fowles J.S., Dailey D.D., Gustafson D.L., Thamm D.H., Duval D.L.
The Flint Animal Cancer Center (FACC) canine tumour cell line panel: a resource for veterinary drug discovery, comparative oncology and translational medicine.
Vet. Comp. Oncol. 15:481-492(2017)

PubMed=31175136; DOI=10.1158/1535-7163.MCT-18-1346
Das S., Idate R., Cronise K.E., Gustafson D.L., Duval D.L.
Identifying candidate druggable targets in canine cancer cell lines using whole exome sequencing.
Mol. Cancer Ther. 18:1460-1471(2019)

Encyclopedic resources Wikidata; Q54813783
Gene expression databases GEO; GSM1974781
Entry history
Entry creation10-Apr-2015
Last entry update29-Jun-2023
Version number15