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| Cell line name |
CML-10C2 |
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| Synonyms |
CML-10c2; CML_10C2; CML10C2 |
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| Accession |
CVCL_0D25 |
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| Resource Identification Initiative |
To cite this cell line use: CML-10C2 (RRID:CVCL_0D25) |
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| Comments |
Part of: FACC canine tumor cell line panel.
Doubling time: 21 hours (PubMed=27257868).
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; Microarray.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029. |
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| Sequence variations |
- Mutation; VGNC; VGNC:42508; KRAS; Simple; p.Gly12Val (c.35G>T); Zygosity=Heterozygous (PubMed=31175136).
|
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| Disease |
Canine oral melanoma (NCIt: C185639) |
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| Species of origin |
Canis lupus familiaris (Dog) (Canis familiaris)
(NCBI Taxonomy: 9615)
Breed/subspecies: Mixed breed; VBO=VBO_0200902. |
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| Hierarchy |
Parent: CVCL_IZ11 (CML-10) |
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| Sex of cell |
Sex unspecified |
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| Age at sampling |
Age unspecified |
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| Category |
Cancer cell line |
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| STR profile |
Source(s): PubMed=27197945; PubMed=31175136
Markers:| Dog FHC2010 | 231 |
| Dog FHC2054 | 156 |
| Dog FHC2079 | 271,291 |
| Dog PEZ1 | 123 |
| Dog PEZ12 | 270,274 |
| Dog PEZ20 | 176 |
| Dog PEZ3 | 119 |
| Dog PEZ5 | 115 |
| Dog PEZ6 | 179,183 |
| Dog PEZ8 | 228,240 |
Run an STR similarity search on this cell line |
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| Publications | PubMed=21908323; DOI=10.1177/1040638711408064
Liza E. O'Donoghue, Jason P. Rivest, Dawn L. Duval;
Polymerase chain reaction-based species verification and microsatellite analysis for canine cell line validation.
J. Vet. Diagn. Invest. 23:780-785(2011) PubMed=22901430; DOI=10.1016/j.jcpa.2012.07.001; PMCID=PMC3535688
Esther Chon, Victoria Thompson, Simone Schmid, Timothy J. Stein;
Activation of the canonical Wnt/beta-catenin signalling pathway is rare in canine malignant melanoma tissue and cell lines.
J. Comp. Pathol. 148:178-187(2013) PubMed=27257868; DOI=10.1371/journal.pone.0156689; PMCID=PMC4892608
Junko Maeda, Coral Eva Froning, Colleen A. Brents, Barbara J. Rose, Douglas H. Thamm, Takamitsu A. Kato;
Intrinsic radiosensitivity and cellular characterization of 27 canine cancer cell lines.
PLoS ONE 11:e0156689.1-e0156689.18(2016) PubMed=27197945; DOI=10.1111/vco.12192; PMCID=PMC5656225
Jared S. Fowles, Deanna D. Dailey, Daniel L. Gustafson, Douglas H. Thamm, Dawn L. Duval;
The Flint Animal Cancer Center (FACC) canine tumour cell line panel: a resource for veterinary drug discovery, comparative oncology and translational medicine.
Vet. Comp. Oncol. 15:481-492(2017) PubMed=31175136; DOI=10.1158/1535-7163.MCT-18-1346; PMCID=PMC6679748
Sunetra Das, Rupa Idate, Kathryn E. Cronise, Daniel L. Gustafson, Dawn L. Duval;
Identifying candidate druggable targets in canine cancer cell lines using whole-exome sequencing.
Mol. Cancer Ther. 18:1460-1471(2019) |
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| Cross-references |
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| Encyclopedic resources |
Wikidata; Q54813783
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| Gene expression databases |
GEO; GSM1974781
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| Entry history |
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| Entry creation | 10-Apr-2015 |
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| Last entry update | 14-Aug-2025 |
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| Version number | 19 |
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