ID   CML-10C2
AC   CVCL_0D25
SY   CML-10c2; CML_10C2; CML10C2
DR   GEO; GSM1974781
DR   Wikidata; Q54813783
RX   PubMed=21908323;
RX   PubMed=22901430;
RX   PubMed=27197945;
RX   PubMed=27257868;
RX   PubMed=31175136;
CC   Part of: FACC canine tumor cell line panel.
CC   Doubling time: 21 hours (PubMed=27257868).
CC   Sequence variation: Mutation; VGNC; VGNC:42508; KRAS; Simple; p.Gly12Val (c.35G>T); Zygosity=Heterozygous (PubMed=31175136).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Transcriptomics; Microarray.
CC   Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
CC   Breed/subspecies: Mixed breed; VBO=VBO_0200902.
ST   Source(s): PubMed=27197945; PubMed=31175136
ST   Dog FHC2010: 231
ST   Dog FHC2054: 156
ST   Dog FHC2079: 271,291
ST   Dog PEZ1: 123
ST   Dog PEZ3: 119
ST   Dog PEZ5: 115
ST   Dog PEZ6: 179,183
ST   Dog PEZ8: 228,240
ST   Dog PEZ12: 270,274
ST   Dog PEZ20: 176
DI   NCIt; C185639; Canine oral melanoma
OX   NCBI_TaxID=9615; ! Canis lupus familiaris (Dog)
HI   CVCL_IZ11 ! CML-10
SX   Sex unspecified
AG   Age unspecified
CA   Cancer cell line
DT   Created: 10-04-15; Last updated: 14-08-25; Version: 19
//
RX   PubMed=27197945; DOI=10.1111/vco.12192; PMCID=PMC5656225;
RA   Fowles, Jared S.
RA   Dailey, Deanna D.
RA   Gustafson, Daniel L.
RA   Thamm, Douglas H.
RA   Duval, Dawn L.
RT   "The Flint Animal Cancer Center (FACC) canine tumour cell line panel:
RT   a resource for veterinary drug discovery, comparative oncology and
RT   translational medicine.";
RL   Vet. Comp. Oncol. 15:481-492(2017).
//
RX   PubMed=27257868; DOI=10.1371/journal.pone.0156689; PMCID=PMC4892608;
RA   Maeda, Junko
RA   Froning, Coral Eva
RA   Brents, Colleen A.
RA   Rose, Barbara J.
RA   Thamm, Douglas H.
RA   Kato, Takamitsu A.
RT   "Intrinsic radiosensitivity and cellular characterization of 27 canine
RT   cancer cell lines.";
RL   PLoS ONE 11:e0156689.1-e0156689.18(2016).
//
RX   PubMed=21908323; DOI=10.1177/1040638711408064;
RA   O'Donoghue, Liza E.
RA   Rivest, Jason P.
RA   Duval, Dawn L.
RT   "Polymerase chain reaction-based species verification and
RT   microsatellite analysis for canine cell line validation.";
RL   J. Vet. Diagn. Invest. 23:780-785(2011).
//
RX   PubMed=22901430; DOI=10.1016/j.jcpa.2012.07.001; PMCID=PMC3535688;
RA   Chon, Esther
RA   Thompson, Victoria
RA   Schmid, Simone
RA   Stein, Timothy J.
RT   "Activation of the canonical Wnt/beta-catenin signalling pathway is
RT   rare in canine malignant melanoma tissue and cell lines.";
RL   J. Comp. Pathol. 148:178-187(2013).
//
RX   PubMed=31175136; DOI=10.1158/1535-7163.MCT-18-1346; PMCID=PMC6679748;
RA   Das, Sunetra
RA   Idate, Rupa
RA   Cronise, Kathryn E.
RA   Gustafson, Daniel L.
RA   Duval, Dawn L.
RT   "Identifying candidate druggable targets in canine cancer cell lines
RT   using whole-exome sequencing.";
RL   Mol. Cancer Ther. 18:1460-1471(2019).
//