ID   CML-10C2
AC   CVCL_0D25
SY   CML-10c2; CML_10C2; CML10C2
DR   GEO; GSM1974781
DR   Wikidata; Q54813783
RX   PubMed=21908323;
RX   PubMed=22901430;
RX   PubMed=27197945;
RX   PubMed=27257868;
RX   PubMed=31175136;
CC   Part of: FACC canine tumor cell line panel.
CC   Doubling time: 21 hours (PubMed=27257868).
CC   Sequence variation: Mutation; VGNC; 42508; KRAS; Simple; p.Gly12Val (c.35G>T); Zygosity=Heterozygous (PubMed=31175136).
CC   Omics: Deep exome analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000027.
ST   Source(s): PubMed=27197945; PubMed=31175136
ST   Dog FHC2010: 231
ST   Dog FHC2054: 156
ST   Dog FHC2079: 271,291
ST   Dog PEZ1: 123
ST   Dog PEZ3: 119
ST   Dog PEZ5: 115
ST   Dog PEZ6: 179,183
ST   Dog PEZ8: 228,240
ST   Dog PEZ12: 270,274
ST   Dog PEZ20: 176
DI   NCIt; C185639; Canine oral melanoma
OX   NCBI_TaxID=9615; ! Canis lupus familiaris (Dog)
HI   CVCL_IZ11 ! CML-10
SX   Sex unspecified
AG   Age unspecified
CA   Cancer cell line
DT   Created: 10-04-15; Last updated: 29-06-23; Version: 15
//
RX   PubMed=21908323; DOI=10.1177/1040638711408064;
RA   O'Donoghue L.E., Rivest J.P., Duval D.L.;
RT   "Polymerase chain reaction-based species verification and
RT   microsatellite analysis for canine cell line validation.";
RL   J. Vet. Diagn. Invest. 23:780-785(2011).
//
RX   PubMed=22901430; DOI=10.1016/j.jcpa.2012.07.001;
RA   Chon E., Thompson V., Schmid S., Stein T.J.;
RT   "Activation of the canonical Wnt/beta-catenin signalling pathway is
RT   rare in canine malignant melanoma tissue and cell lines.";
RL   J. Comp. Pathol. 148:178-187(2013).
//
RX   PubMed=27197945; DOI=10.1111/vco.12192;
RA   Fowles J.S., Dailey D.D., Gustafson D.L., Thamm D.H., Duval D.L.;
RT   "The Flint Animal Cancer Center (FACC) canine tumour cell line panel:
RT   a resource for veterinary drug discovery, comparative oncology and
RT   translational medicine.";
RL   Vet. Comp. Oncol. 15:481-492(2017).
//
RX   PubMed=27257868; DOI=10.1371/journal.pone.0156689;
RA   Maeda J., Froning C.E., Brents C.A., Rose B.J., Thamm D.H., Kato T.A.;
RT   "Intrinsic radiosensitivity and cellular characterization of 27 canine
RT   cancer cell lines.";
RL   PLoS ONE 11:E0156689-E0156689(2016).
//
RX   PubMed=31175136; DOI=10.1158/1535-7163.MCT-18-1346;
RA   Das S., Idate R., Cronise K.E., Gustafson D.L., Duval D.L.;
RT   "Identifying candidate druggable targets in canine cancer cell lines
RT   using whole exome sequencing.";
RL   Mol. Cancer Ther. 18:1460-1471(2019).
//