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Cellosaurus MOCHA (CVCL_0C87)

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Cell line name MOCHA
Accession CVCL_0C87
Resource Identification Initiative To cite this cell line use: MOCHA (RRID:CVCL_0C87)
Comments Population: Caucasian.
Virology: Highly susceptible to infection by both CCR5-tropic and CXCR4-tropic HIV-1 strains. SEAP (secreted ALPP) reporter cell line, in this cell line SEAP is under the control of a HIV-1 long terminal repeat. This cell line secretes human placental alkaline phosphatase into the culture supernatant during HIV-1 infection.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:439; ALPP.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:1606; CCR5.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1600Pro (c.4799T>C); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Pro2514Argfs*4 (c.7541_7542delCT); ClinVar=VCV000581973; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly12Cys (c.34G>T); ClinVar=VCV000040468; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys267Argfs*9 (c.800delA) (p.Leu265fs, c.795delA); ClinVar=VCV000092828; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11389; STK11; Simple; p.Gln214Ter (c.640C>T); ClinVar=VCV000428759; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg306Ter (c.916C>T); ClinVar=VCV000142144; Zygosity=Heterozygous (from parent cell line).
Disease Adult T acute lymphoblastic leukemia (NCIt: C9142)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_S545 (MOLT-4/CCR5)
Sex of cell Male
Age at sampling 19Y
Category Cancer cell line
Publications

PubMed=12791875; DOI=10.1128/jcm.41.6.2515-2521.2003; PMCID=PMC156554
Hiroshi Miyake, Yuji Iizawa, Masanori Baba;
Novel reporter T-cell line highly susceptible to both CCR5- and CXCR4-using human immunodeficiency virus type 1 and its application to drug susceptibility tests.
J. Clin. Microbiol. 41:2515-2521(2003)

Cross-references
Cell line databases/resources cancercelllines; CVCL_0C87
Encyclopedic resources Wikidata; Q54906293
Entry history
Entry creation10-Apr-2015
Last entry update19-Dec-2024
Version number19