ID   MOCHA
AC   CVCL_0C87
DR   cancercelllines; CVCL_0C87
DR   Wikidata; Q54906293
RX   PubMed=12791875;
CC   Population: Caucasian.
CC   Virology: Highly susceptible to infection by both CCR5-tropic and CXCR4-tropic HIV-1 strains. SEAP (secreted ALPP) reporter cell line, in this cell line SEAP is under the control of a HIV-1 long terminal repeat. This cell line secretes human placental alkaline phosphatase into the culture supernatant during HIV-1 infection.
CC   Sequence variation: Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1600Pro (c.4799T>C); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Pro2514Argfs*4 (c.7541_7542delCT); ClinVar=VCV000581973; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly12Cys (c.34G>T); ClinVar=VCV000040468; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys267Argfs*9 (c.800delA) (p.Leu265fs, c.795delA); ClinVar=VCV000092828; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11389; STK11; Simple; p.Gln214Ter (c.640C>T); ClinVar=VCV000428759; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg306Ter (c.916C>T); ClinVar=VCV000142144; Zygosity=Heterozygous (from parent cell line).
CC   Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:439; ALPP.
CC   Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:1606; CCR5.
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: T-cell; CL=CL_0000084.
DI   NCIt; C9142; Adult T acute lymphoblastic leukemia
DI   ORDO; Orphanet_99861; Precursor T-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_S545 ! MOLT-4/CCR5
SX   Male
AG   19Y
CA   Cancer cell line
DT   Created: 10-04-15; Last updated: 19-12-24; Version: 19
//
RX   PubMed=12791875; DOI=10.1128/jcm.41.6.2515-2521.2003; PMCID=PMC156554;
RA   Miyake, Hiroshi
RA   Iizawa, Yuji
RA   Baba, Masanori
RT   "Novel reporter T-cell line highly susceptible to both CCR5- and
RT   CXCR4-using human immunodeficiency virus type 1 and its application to
RT   drug susceptibility tests.";
RL   J. Clin. Microbiol. 41:2515-2521(2003).
//