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Cellosaurus HCC-1.2 (CVCL_0C53)

[Text version]
Cell line name HCC-1.2
Synonyms HCC.1.2; HCC1.2; 1.2; 3P; 3p
Accession CVCL_0C53
Resource Identification Initiative To cite this cell line use: HCC-1.2 (RRID:CVCL_0C53)
Comments Miscellaneous: Direct author submission of STR profile from Rohr-Udilova N.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Disease Hepatitis C infection (NCIt: C3098)
Adult hepatocellular carcinoma (NCIt: C7956)
Adult hepatocellular carcinoma (ORDO: Orphanet_210159)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_0C42 ! BLC-1
CVCL_0C52 ! HCC-1.1
CVCL_0C47 ! MF-1 [Human]
Sex of cell Male
Age at sampling 56Y
Category Cancer cell line
STR profile Source(s): Direct_author_submission

Markers:
AmelogeninX
CSF1PO10,12
D3S135815,16
D5S81810,13
D7S8209,10
D8S117911,13
D13S31712
D16S5399
D18S5114,16
D21S1128,29
FGA20
Penta D12,13
Penta E10,12
TH017,9.3
TPOX8,9
vWA17

Run an STR similarity search on this cell line
Web pages Info; LCCL; -; https://lccl.zucmanlab.com/hcc/cellLines/HCC.1.2
Publications

PubMed=18594539; DOI=10.1038/sj.bjc.6604440; PMCID=PMC2453035
Sagmeister S., Eisenbauer M., Pirker C., Mohr T., Holzmann K., Zwickl H., Bichler C., Kandioler-Eckersberger D., Wrba F., Mikulits W., Gerner C., Shehata M., Majdic O., Streubel B., Berger W., Micksche M., Zatloukal K., Schulte-Hermann R., Grasl-Kraupp B.
New cellular tools reveal complex epithelial-mesenchymal interactions in hepatocarcinogenesis.
Br. J. Cancer 99:151-159(2008)

PubMed=21364009; DOI=10.1158/1535-7163.MCT-10-0917
van Zijl F., Mall S., Machat G., Pirker C., Zeillinger R., Weinhaeusel A., Bilban M., Berger W., Mikulits W.
A human model of epithelial to mesenchymal transition to monitor drug efficacy in hepatocellular carcinoma progression.
Mol. Cancer Ther. 10:850-860(2011)

PubMed=23887712; DOI=10.1038/ncomms3218; PMCID=PMC3731665
Nault J.-C., Mallet M., Pilati C., Calderaro J., Bioulac-Sage P., Laurent C., Laurent A., Cherqui D., Balabaud C., Zucman-Rossi J.
High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions.
Nat. Commun. 4:2218.1-2218.7(2013)

Cross-references
Chemistry resources ChEMBL-Cells; CHEMBL4295407
ChEMBL-Targets; CHEMBL4296419
PubChem_Cell_line; CVCL_0C53
Encyclopedic resources Wikidata; Q54881505
Polymorphism and mutation databases Cosmic; 1628382
Cosmic; 2162520
Cosmic; 2162521
Entry history
Entry creation10-Apr-2015
Last entry update10-Apr-2025
Version number11