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Cellosaurus H69/VP (CVCL_0B23)

[Text version]
Cell line name H69/VP
Accession CVCL_0B23
Resource Identification Initiative To cite this cell line use: H69/VP (RRID:CVCL_0B23)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_4911; Etoposide (VP-16).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Gly106_Arg108del (c.317_325delGGCAACCGT); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9884; RB1; Simple; p.Glu748Ter (c.2242G>T); ClinVar=VCV000013078; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu171Ter (c.511G>T); ClinVar=VCV000634771; Zygosity=Homozygous (from parent cell line).
Disease Lung small cell carcinoma (NCIt: C4917)
Small cell lung cancer (ORDO: Orphanet_70573)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1579 (NCI-H69)
Sex of cell Male
Age at sampling 55Y
Category Cancer cell line
Publications

PubMed=8784480; DOI=10.1159/000227600
Akinori Shinohara, Eiji Shimizu, Minoru Takada, Saburo Sone;
Lack of c-mpl proto-oncogene transcripts and growth-stimulatory effects of thrombopoietin on human small cell lung cancer cell lines.
Oncology 53:426-434(1996)

PubMed=9062409; DOI=10.1038/bjc.1997.154; PMCID=PMC2063407
Peter Buhl Jensen, Bente Holm, Morten Sorensen, Ib Jarle Christensen, Maxwell Sehested;
In vitro cross-resistance and collateral sensitivity in seven resistant small-cell lung cancer cell lines: preclinical identification of suitable drug partners to taxotere, taxol, topotecan and gemcitabin.
Br. J. Cancer 75:869-877(1997)

Cross-references
Cell line databases/resources cancercelllines; CVCL_0B23
Encyclopedic resources Wikidata; Q54872203
Entry history
Entry creation10-Apr-2015
Last entry update19-Dec-2024
Version number15