ID   H69/VP
AC   CVCL_0B23
DR   cancercelllines; CVCL_0B23
DR   Wikidata; Q54872203
RX   PubMed=8784480;
RX   PubMed=9062409;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI_4911; Etoposide (VP-16).
CC   Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Gly106_Arg108del (c.317_325delGGCAACCGT); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9884; RB1; Simple; p.Glu748Ter (c.2242G>T); ClinVar=VCV000013078; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu171Ter (c.511G>T); ClinVar=VCV000634771; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C4917; Lung small cell carcinoma
DI   ORDO; Orphanet_70573; Small cell lung cancer
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1579 ! NCI-H69
SX   Male
AG   55Y
CA   Cancer cell line
DT   Created: 10-04-15; Last updated: 19-12-24; Version: 15
//
RX   PubMed=8784480; DOI=10.1159/000227600;
RA   Shinohara, Akinori
RA   Shimizu, Eiji
RA   Takada, Minoru
RA   Sone, Saburo
RT   "Lack of c-mpl proto-oncogene transcripts and growth-stimulatory
RT   effects of thrombopoietin on human small cell lung cancer cell
RT   lines.";
RL   Oncology 53:426-434(1996).
//
RX   PubMed=9062409; DOI=10.1038/bjc.1997.154; PMCID=PMC2063407;
RA   Jensen, Peter Buhl
RA   Holm, Bente
RA   Sorensen, Morten
RA   Christensen, Ib Jarle
RA   Sehested, Maxwell
RT   "In vitro cross-resistance and collateral sensitivity in seven
RT   resistant small-cell lung cancer cell lines: preclinical
RT   identification of suitable drug partners to taxotere, taxol, topotecan
RT   and gemcitabin.";
RL   Br. J. Cancer 75:869-877(1997).
//