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Cellosaurus BS-C-1 (CVCL_0607)

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Cell line name BS-C-1
Synonyms BSC-1; BSC1; GMK,BSC-1; Biologics Standards-Cercopithecus-1
Accession CVCL_0607
Resource Identification Initiative To cite this cell line use: BS-C-1 (RRID:CVCL_0607)
Comments Group: Non-human primate cell line.
Problematic cell line: Misidentified. Originally thought to be of Chlorocebus aethiops origin but found to be from Chlorocebus pygerythrus (PubMed=33458215).
Characteristics: Suitable for transfection by SV40 and may be used for the detection of viruses (ATCC=CCL-26).
Doubling time: 72 hours (Note=At 68th passage) (PubMed=14071033).
Omics: Mitochondrial genome sequenced.
Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
Sequence variations
  • Mutation; UniProtKB; A0A7D5U6M6; MT-ND6; Simple; p.Tyr50fs*25 (c.147insG) (m.13952dupC); Zygosity=Heteroplasmic; Note=In a majority of mitochondria (PubMed=33458215).
Species of origin Chlorocebus pygerythrus (Vervet monkey) (Cercopithecus pygerythrus) (NCBI Taxonomy: 60710)
Hierarchy Children:
CVCL_VS63 (BMT10)CVCL_VS64 (BOS4)CVCL_3656 (BSC40)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Spontaneously immortalized cell line
Web pages https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/b/cell-lines-detail-526.html

PubMed=14473108; DOI=10.4049/jimmunol.88.6.796
Meyer H.M. Jr., Hopps H.E., Rogers N.G., Brooks B.E., Bernheim B.C., Jones W.P., Nisalak A., Douglas R.D.
Studies on simian virus 40.
J. Immunol. 88:796-806(1962)

PubMed=14071033; DOI=10.4049/jimmunol.91.3.416
Hopps H.E., Bernheim B.C., Nisalak A., Tjio J.H., Smadel J.E.
Biologic characteristics of a continuous kidney cell line derived from the African green monkey.
J. Immunol. 91:416-424(1963)

Schmidt N.J., Lennette E.H., Shon C.W., Dennis J.
The sensitivity of grivet monkey kidney cell line BS-C-1 for propagation and isolation of certain human viruses.
Am. J. Public Health Nations Health 54:1522-1530(1964)

Stulberg C.S., Coriell L.L., Kniazeff A.J., Shannon J.E.
The animal cell culture collection.
In Vitro 5:1-16(1970)

Petricciani J.C., Wallace R.E., McCoy D.W.
A comparison of three in vivo assays for cell tumorigenicity.
Cancer Res. 34:105-108(1974)

PubMed=303774; DOI=10.1073/pnas.74.11.5046
Holley R.W., Armour R., Baldwin J.H., Brown K.D., Yeh Y.-C.
Density-dependent regulation of growth of BSC-1 cells in cell culture: control of growth by serum factors.
Proc. Natl. Acad. Sci. U.S.A. 74:5046-5050(1977)

PubMed=272650; DOI=10.1073/pnas.75.1.339
Holley R.W., Armour R., Baldwin J.H.
Density-dependent regulation of growth of BSC-1 cells in cell culture: control of growth by low molecular weight nutrients.
Proc. Natl. Acad. Sci. U.S.A. 75:339-341(1978)

PubMed=6988327; DOI=10.1007/BF02831503
O'Brien S.J., Shannon J.E., Gail M.H.
A molecular approach to the identification and individualization of human and animal cells in culture: isozyme and allozyme genetic signatures.
In Vitro 16:119-135(1980)

PubMed=28046048; DOI=10.1371/journal.pone.0169391
Dotti S., Lombardo T., Villa R., Cacciamali A., Zanotti C., Andreani N.A., Cinotti S., Ferrari M.
Transformation and tumorigenicity testing of simian cell lines and evaluation of poliovirus replication.
PLoS ONE 12:E0169391-E0169391(2017)

PubMed=33458215; DOI=10.1080/23802359.2020.1827067
Kozhukhar N., Alexeyev M.F.
The mitochondrial genome sequence of the BS-C-1 cell line is at odds with the reported derivation from Cercopithecus aethiops.
Mitochondrial DNA B. Resour. 5:3492-3494(2020)

Cell line collections (Providers) ATCC; CCL-26
BCRC; 60078
CLS; 305009
ECACC; 85011422
JCRB; IFO50413
JCRB; JCRB9011 - Discontinued
KCLB; 10026
NCBI_Iran; C484
Cell line databases/resources CLO; CLO_0002035
CLO; CLO_0002036
CLO; CLO_0002037
CLDB; cl484
CLDB; cl486
CLDB; cl487
CCRID; 1101MON-PUMC000098
Chemistry resources ChEMBL-Cells; CHEMBL3307388
ChEMBL-Targets; CHEMBL614528
PubChem_Cell_line; CVCL_0607
Encyclopedic resources Wikidata; Q38086318
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number22