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Cellosaurus BS-C-1 (CVCL_0607)

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Cell line name BS-C-1
Synonyms BSC-1; BSC1; GMK,BSC-1; Biologics Standards-Cercopithecus-1
Accession CVCL_0607
Resource Identification Initiative To cite this cell line use: BS-C-1 (RRID:CVCL_0607)
Comments Group: Non-human primate cell line.
Problematic cell line: Misidentified. Originally thought to be of Chlorocebus aethiops origin but found to be from Chlorocebus pygerythrus (PubMed=33458215).
Characteristics: Suitable for transfection by SV40 and may be used for the detection of viruses (ATCC=CCL-26).
Doubling time: 72 hours (Note=At 68th passage) (PubMed=14071033).
Omics: Genomics; Mitochondrial genome sequencing.
Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
Sequence variations
  • Mutation; UniProtKB; A0A7D5U6M6; MT-ND6; Simple; p.Tyr50fs*25 (c.147insG) (m.13952dupC); Zygosity=Heteroplasmic; Note=In a majority of mitochondria (PubMed=33458215).
Species of origin Chlorocebus pygerythrus (Vervet monkey) (Cercopithecus pygerythrus) (NCBI Taxonomy: 60710)
Hierarchy Children:
CVCL_VS63 (BMT10)CVCL_VS64 (BOS4)CVCL_3656 (BSC40)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Spontaneously immortalized cell line
Web pages Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/b/cell-lines-detail-526.html
Publications

PubMed=14473108; DOI=10.4049/jimmunol.88.6.796
Harry Martin Meyer Jr., Hope Elizabeth Hopps, Nancy G. Rogers, Barbara E. Brooks, Barbara C. Bernheim, William P. Jones, Ananda Nisalak, Robert D. Douglas;
Studies on simian virus 40.
J. Immunol. 88:796-806(1962)

PubMed=14071033; DOI=10.4049/jimmunol.91.3.416
Hope Elizabeth Hopps, Barbara C. Bernheim, Ananda Nisalak, Joe Hin Tjio, Joseph Edward Smadel;
Biologic characteristics of a continuous kidney cell line derived from the African green monkey.
J. Immunol. 91:416-424(1963)

PubMed=14215895; DOI=10.2105/ajph.54.9.1522; PMCID=PMC1255005
Nathalie J. Schmidt, Edwin Herman Lennette, Carol W. Shon, Juanita Dennis;
The sensitivity of grivet monkey kidney cell line BS-C-1 for propagation and isolation of certain human viruses.
Am. J. Public Health Nations Health 54:1522-1530(1964)

DOI=10.1007/BF02618370
Cyril S. Stulberg, Lewis Lemon Coriell, Alexis John Kniazeff, John E. Shannon;
The animal cell culture collection.
In Vitro 5:1-16(1970)

PubMed=4203458
John C. Petricciani, Roslyn Elizabeth Wallace, Donald W. McCoy;
A comparison of three in vivo assays for cell tumorigenicity.
Cancer Res. 34:105-108(1974)

PubMed=303774; DOI=10.1073/pnas.74.11.5046; PMCID=PMC432095
Robert William Holley, Rosemary Armour, Julia H. Baldwin, Kenneth D. Brown, Yun-Chi Yeh;
Density-dependent regulation of growth of BSC-1 cells in cell culture: control of growth by serum factors.
Proc. Natl. Acad. Sci. U.S.A. 74:5046-5050(1977)

PubMed=272650; DOI=10.1073/pnas.75.1.339; PMCID=PMC411243
Robert William Holley, Rosemary Armour, Julia H. Baldwin;
Density-dependent regulation of growth of BSC-1 cells in cell culture: control of growth by low molecular weight nutrients.
Proc. Natl. Acad. Sci. U.S.A. 75:339-341(1978)

PubMed=6988327; DOI=10.1007/BF02831503
Stephen James O'Brien, John E. Shannon, Mitchell H. Gail;
A molecular approach to the identification and individualization of human and animal cells in culture: isozyme and allozyme genetic signatures.
In Vitro 16:119-135(1980)

PubMed=28046048; DOI=10.1371/journal.pone.0169391; PMCID=PMC5207746
Silvia Dotti, Tina Lombardo, Riccardo Villa, Andrea Cacciamali, Cinzia Zanotti, Nadia Andrea Andreani, Stefano Cinotti, Maura Ferrari;
Transformation and tumorigenicity testing of simian cell lines and evaluation of poliovirus replication.
PLoS ONE 12:e0169391.1-e0169391.13(2017)

PubMed=33458215; DOI=10.1080/23802359.2020.1827067; PMCID=PMC7781988
Nataliya Kozhukhar, Mikhail F. Alexeyev;
The mitochondrial genome sequence of the BS-C-1 cell line is at odds with the reported derivation from Cercopithecus aethiops.
Mitochondrial DNA B. Resour. 5:3492-3494(2020)

Cross-references
Cell line collections (Providers) ATCC; CCL-26
BCRC; 60078
CCTCC; GDC0033
CLS; 305009
ECACC; 85011422
IZSLER; BS CL 9
JCRB; IFO50413
JCRB; JCRB9011 - Discontinued
JCRB; JCRB9126
KCLB; 10026
NCBI_Iran; C484
Cell line databases/resources CLO; CLO_0002035
CLO; CLO_0002036
CLO; CLO_0002037
CLDB; cl484
CLDB; cl486
CLDB; cl487
CCRID; 1101MON-PUMC000098
CCRID; 1102MON-NIFDC00094
CCRID; 4201MON-CCTCC00033
Chemistry resources ChEMBL-Cells; CHEMBL3307388
ChEMBL-Targets; CHEMBL614528
PubChem_Cell_line; CVCL_0607
Encyclopedic resources Wikidata; Q38086318
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number23