ID   BS-C-1
AC   CVCL_0607
SY   BSC-1; BSC1; GMK,BSC-1; Biologics Standards-Cercopithecus-1
DR   CLO; CLO_0002035
DR   CLO; CLO_0002036
DR   CLO; CLO_0002037
DR   CLDB; cl484
DR   CLDB; cl486
DR   CLDB; cl487
DR   BCRC; 60078
DR   CCRID; 1101MON-PUMC000098
DR   CCRID; 1102MON-NIFDC00094
DR   CCRID; 4201MON-CCTCC00033
DR   ChEMBL-Cells; CHEMBL3307388
DR   ChEMBL-Targets; CHEMBL614528
DR   CLS; 305009
DR   ECACC; 85011422
DR   JCRB; IFO50413
DR   KCLB; 10026
DR   NCBI_Iran; C484
DR   PubChem_Cell_line; CVCL_0607
DR   Wikidata; Q38086318
RX   DOI=10.1007/BF02618370;
RX   PubMed=272650;
RX   PubMed=303774;
RX   PubMed=4203458;
RX   PubMed=6988327;
RX   PubMed=14071033;
RX   PubMed=14215895;
RX   PubMed=14473108;
RX   PubMed=28046048;
RX   PubMed=33458215;
CC   Group: Non-human primate cell line.
CC   Problematic cell line: Misidentified. Originally thought to be of Chlorocebus aethiops origin but found to be from Chlorocebus pygerythrus (PubMed=33458215).
CC   Characteristics: Suitable for transfection by SV40 and may be used for the detection of viruses (ATCC=CCL-26).
CC   Doubling time: 72 hours (Note=At 68th passage) (PubMed=14071033).
CC   Sequence variation: Mutation; UniProtKB; A0A7D5U6M6; MT-ND6; Simple; p.Tyr50fs*25 (c.147insG) (m.13952dupC); Zygosity=Heteroplasmic; Note=In a majority of mitochondria (PubMed=33458215).
CC   Omics: Mitochondrial genome sequenced.
CC   Discontinued: JCRB; JCRB9011; true.
CC   Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
OX   NCBI_TaxID=60710; ! Chlorocebus pygerythrus (Vervet monkey)
SX   Sex unspecified
AG   Age unspecified
CA   Spontaneously immortalized cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 22
RX   DOI=10.1007/BF02618370;
RA   Stulberg C.S., Coriell L.L., Kniazeff A.J., Shannon J.E.;
RT   "The animal cell culture collection.";
RL   In Vitro 5:1-16(1970).
RX   PubMed=272650; DOI=10.1073/pnas.75.1.339;
RA   Holley R.W., Armour R., Baldwin J.H.;
RT   "Density-dependent regulation of growth of BSC-1 cells in cell
RT   culture: control of growth by low molecular weight nutrients.";
RL   Proc. Natl. Acad. Sci. U.S.A. 75:339-341(1978).
RX   PubMed=303774; DOI=10.1073/pnas.74.11.5046;
RA   Holley R.W., Armour R., Baldwin J.H., Brown K.D., Yeh Y.-C.;
RT   "Density-dependent regulation of growth of BSC-1 cells in cell
RT   culture: control of growth by serum factors.";
RL   Proc. Natl. Acad. Sci. U.S.A. 74:5046-5050(1977).
RX   PubMed=4203458;
RA   Petricciani J.C., Wallace R.E., McCoy D.W.;
RT   "A comparison of three in vivo assays for cell tumorigenicity.";
RL   Cancer Res. 34:105-108(1974).
RX   PubMed=6988327; DOI=10.1007/BF02831503;
RA   O'Brien S.J., Shannon J.E., Gail M.H.;
RT   "A molecular approach to the identification and individualization of
RT   human and animal cells in culture: isozyme and allozyme genetic
RT   signatures.";
RL   In Vitro 16:119-135(1980).
RX   PubMed=14071033; DOI=10.4049/jimmunol.91.3.416;
RA   Hopps H.E., Bernheim B.C., Nisalak A., Tjio J.H., Smadel J.E.;
RT   "Biologic characteristics of a continuous kidney cell line derived
RT   from the African green monkey.";
RL   J. Immunol. 91:416-424(1963).
RX   PubMed=14215895;
RA   Schmidt N.J., Lennette E.H., Shon C.W., Dennis J.;
RT   "The sensitivity of grivet monkey kidney cell line BS-C-1 for
RT   propagation and isolation of certain human viruses.";
RL   Am. J. Public Health Nations Health 54:1522-1530(1964).
RX   PubMed=14473108; DOI=10.4049/jimmunol.88.6.796;
RA   Meyer H.M. Jr., Hopps H.E., Rogers N.G., Brooks B.E., Bernheim B.C.,
RA   Jones W.P., Nisalak A., Douglas R.D.;
RT   "Studies on simian virus 40.";
RL   J. Immunol. 88:796-806(1962).
RX   PubMed=28046048; DOI=10.1371/journal.pone.0169391;
RA   Dotti S., Lombardo T., Villa R., Cacciamali A., Zanotti C.,
RA   Andreani N.A., Cinotti S., Ferrari M.;
RT   "Transformation and tumorigenicity testing of simian cell lines and
RT   evaluation of poliovirus replication.";
RL   PLoS ONE 12:E0169391-E0169391(2017).
RX   PubMed=33458215; DOI=10.1080/23802359.2020.1827067;
RA   Kozhukhar N., Alexeyev M.F.;
RT   "The mitochondrial genome sequence of the BS-C-1 cell line is at odds
RT   with the reported derivation from Cercopithecus aethiops.";
RL   Mitochondrial DNA B. Resour. 5:3492-3494(2020).