ID   BS-C-1
AC   CVCL_0607
SY   BSC-1; BSC1; GMK,BSC-1; Biologics Standards-Cercopithecus-1
DR   CLO; CLO_0002035
DR   CLO; CLO_0002036
DR   CLO; CLO_0002037
DR   CLDB; cl484
DR   CLDB; cl486
DR   CLDB; cl487
DR   ATCC; CCL-26
DR   BCRC; 60078
DR   CCRID; 1101MON-PUMC000098
DR   CCRID; 1102MON-NIFDC00094
DR   CCRID; 4201MON-CCTCC00033
DR   CCTCC; GDC0033
DR   ChEMBL-Cells; CHEMBL3307388
DR   ChEMBL-Targets; CHEMBL614528
DR   CLS; 305009
DR   ECACC; 85011422
DR   IZSLER; BS CL 9
DR   JCRB; IFO50413
DR   JCRB; JCRB9011
DR   JCRB; JCRB9126
DR   KCLB; 10026
DR   NCBI_Iran; C484
DR   PubChem_Cell_line; CVCL_0607
DR   Wikidata; Q38086318
RX   DOI=10.1007/BF02618370;
RX   PubMed=272650;
RX   PubMed=303774;
RX   PubMed=3024506;
RX   PubMed=4203458;
RX   PubMed=4339410;
RX   PubMed=6988327;
RX   PubMed=14071033;
RX   PubMed=14215895;
RX   PubMed=14473108;
RX   PubMed=28046048;
RX   PubMed=33458215;
WW   Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/b/cell-lines-detail-526.html
CC   Group: Non-human primate cell line.
CC   Problematic cell line: Misidentified. Originally thought to be of Chlorocebus aethiops origin but found to be from Chlorocebus pygerythrus (PubMed=33458215).
CC   Characteristics: Suitable for transfection by SV40 and may be used for the detection of viruses (ATCC=CCL-26).
CC   Doubling time: 72 hours (Note=At 68th passage) (PubMed=14071033).
CC   Sequence variation: Mutation; UniProtKB; A0A7D5U6M6; MT-ND6; Simple; p.Tyr50fs*25 (c.147insG) (m.13952dupC); Zygosity=Heteroplasmic; Note=In a majority of mitochondria (PubMed=33458215).
CC   Omics: Genomics; Mitochondrial genome sequencing.
CC   Discontinued: JCRB; JCRB9011; true.
CC   Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
CC   Cell type: Epithelial cell of kidney; CL=CL_0002518.
OX   NCBI_TaxID=60710; ! Chlorocebus pygerythrus (Vervet monkey)
SX   Sex unspecified
AG   Age unspecified
CA   Spontaneously immortalized cell line
DT   Created: 04-04-12; Last updated: 27-11-25; Version: 24
CH   CVCL_VS63 ! BMT10
CH   CVCL_VS64 ! BOS4
CH   CVCL_F0RT ! BSC-SV Cl 1.1
CH   CVCL_3656 ! BSC40
//
RX   PubMed=4339410; DOI=10.1002/ijc.2910090210;
RA   Suarez, Horacio Guillermo
RA   Bourali, Marie-France
RA   Wicker, Rene
RA   Estrade, Simone
RA   Cassingena, Roland
RT   "Properties of an SV40-transformed African green monkey kidney (BSC-1)
RT   cell line.";
RL   Int. J. Cancer 9:324-333(1972).
//
RX   PubMed=303774; DOI=10.1073/pnas.74.11.5046; PMCID=PMC432095;
RA   Holley, Robert William
RA   Armour, Rosemary
RA   Baldwin, Julia H.
RA   Brown, Kenneth D.
RA   Yeh, Yun-Chi
RT   "Density-dependent regulation of growth of BSC-1 cells in cell
RT   culture: control of growth by serum factors.";
RL   Proc. Natl. Acad. Sci. U.S.A. 74:5046-5050(1977).
//
RX   PubMed=14215895; DOI=10.2105/ajph.54.9.1522; PMCID=PMC1255005;
RA   Schmidt, Nathalie J.
RA   Lennette, Edwin Herman
RA   Shon, Carol W.
RA   Dennis, Juanita
RT   "The sensitivity of grivet monkey kidney cell line BS-C-1 for
RT   propagation and isolation of certain human viruses.";
RL   Am. J. Public Health Nations Health 54:1522-1530(1964).
//
RX   DOI=10.1007/BF02618370;
RA   Stulberg, Cyril S.
RA   Coriell, Lewis Lemon
RA   Kniazeff, Alexis John
RA   Shannon, John E.
RT   "The animal cell culture collection.";
RL   In Vitro 5:1-16(1970).
//
RX   PubMed=6988327; DOI=10.1007/BF02831503;
RA   O'Brien, Stephen James
RA   Shannon, John E.
RA   Gail, Mitchell H.
RT   "A molecular approach to the identification and individualization of
RT   human and animal cells in culture: isozyme and allozyme genetic
RT   signatures.";
RL   In Vitro 16:119-135(1980).
//
RX   PubMed=14071033; DOI=10.4049/jimmunol.91.3.416;
RA   Hopps, Hope Elizabeth
RA   Bernheim, Barbara C.
RA   Nisalak, Ananda
RA   Tjio, Joe Hin
RA   Smadel, Joseph Edward
RT   "Biologic characteristics of a continuous kidney cell line derived
RT   from the African green monkey.";
RL   J. Immunol. 91:416-424(1963).
//
RX   PubMed=14473108; DOI=10.4049/jimmunol.88.6.796;
RA   Meyer, Harry Martin Jr.
RA   Hopps, Hope Elizabeth
RA   Rogers, Nancy G.
RA   Brooks, Barbara E.
RA   Bernheim, Barbara C.
RA   Jones, William P.
RA   Nisalak, Ananda
RA   Douglas, Robert D.
RT   "Studies on simian virus 40.";
RL   J. Immunol. 88:796-806(1962).
//
RX   PubMed=272650; DOI=10.1073/pnas.75.1.339; PMCID=PMC411243;
RA   Holley, Robert William
RA   Armour, Rosemary
RA   Baldwin, Julia H.
RT   "Density-dependent regulation of growth of BSC-1 cells in cell
RT   culture: control of growth by low molecular weight nutrients.";
RL   Proc. Natl. Acad. Sci. U.S.A. 75:339-341(1978).
//
RX   PubMed=28046048; DOI=10.1371/journal.pone.0169391; PMCID=PMC5207746;
RA   Dotti, Silvia
RA   Lombardo, Tina
RA   Villa, Riccardo
RA   Cacciamali, Andrea
RA   Zanotti, Cinzia
RA   Andreani, Nadia Andrea
RA   Cinotti, Stefano
RA   Ferrari, Maura
RT   "Transformation and tumorigenicity testing of simian cell lines and
RT   evaluation of poliovirus replication.";
RL   PLoS ONE 12:e0169391.1-e0169391.13(2017).
//
RX   PubMed=33458215; DOI=10.1080/23802359.2020.1827067; PMCID=PMC7781988;
RA   Kozhukhar, Nataliya
RA   Alexeyev, Mikhail F.
RT   "The mitochondrial genome sequence of the BS-C-1 cell line is at odds
RT   with the reported derivation from Cercopithecus aethiops.";
RL   Mitochondrial DNA B. Resour. 5:3492-3494(2020).
//
RX   PubMed=4203458;
RA   Petricciani, John C.
RA   Wallace, Roslyn Elizabeth
RA   McCoy, Donald W.
RT   "A comparison of three in vivo assays for cell tumorigenicity.";
RL   Cancer Res. 34:105-108(1974).
//
RX   PubMed=3024506; DOI=10.1152/ajprenal.1986.251.6.F954;
RA   Jentsch, Thomas J.
RA   Matthes, Harald
RA   Keller, Svea K.
RA   Wiederholt, Michael
RT   "Electrical properties of sodium bicarbonate symport in kidney
RT   epithelial cells (BSC-1).";
RL   Am. J. Physiol. 251:F954-F968(1986).
//