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Cellosaurus SH-SY5Y-SPA4CT (CVCL_0523)

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Cell line name SH-SY5Y-SPA4CT
Synonyms SH-SY5Y SPA4CT; SHSY5Y-SPA4CT; SPA4CT
Accession CVCL_0523
Resource Identification Initiative To cite this cell line use: SH-SY5Y-SPA4CT (RRID:CVCL_0523)
Comments Population: Caucasian.
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:620; APP (Note=With p.Val20_Met671del = SPA4CT).
Genetic integration: Method=Transfection; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Mutation; HGNC; HGNC:427; ALK; Simple; p.Phe1174Leu (c.3522C>A); ClinVar=VCV000217852; Zygosity=Unspecified (from parent cell line).
Disease Neuroblastoma (NCIt: C3270)
Neuroblastoma (ORDO: Orphanet_635)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0019 (SH-SY5Y)
Sex of cell Female
Age at sampling 4Y
Category Cancer cell line
Publications

PubMed=8243673; DOI=10.1016/0014-5793(93)80446-2
Thomas Dyrks, Elke Dyrks, Ulla Monning, Britta Urmoneit, Jonathan Turner, Konrad Beyreuther;
Generation of beta A4 from the amyloid protein precursor and fragments thereof.
FEBS Lett. 335:89-93(1993)

Cross-references
Cell line databases/resources MCCL; MCC:0000422
cancercelllines; CVCL_0523
Encyclopedic resources Wikidata; Q54953228
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number21