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Cellosaurus ROS 17/2.8 (CVCL_0508)

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Cell line name ROS 17/2.8
Synonyms ROS 17/28; Ros 17/2.8; ROS-17/2.8; ROS17/28; ROS17/2.8
Accession CVCL_0508
Resource Identification Initiative To cite this cell line use: ROS 17/2.8 (RRID:CVCL_0508)
Comments Group: Space-flown cell line (cellonaut).
Anecdotal: Have been flown in space on Cosmos-2229 (Bion-10), Foton-11 and Foton-12 to study growth and cytoskeletal changes in microgravity (PubMed=9028534; PubMed=11511518).
Derived from site: In situ; Bone; UBERON=UBERON_0002481.
Disease Rat osteosarcoma (NCIt: C60487)
Species of origin Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)
Breed/subspecies: ACI 9935.
Hierarchy Parent: CVCL_IR39 (ROS 17/2)
CVCL_U259 (ROS 17/2.8-5)
Category Cancer cell line

PubMed=3855255; DOI=10.1210/endo-116-1-170
Majeska R.J., Nair B.C., Rodan G.A.
Glucocorticoid regulation of alkaline phosphatase in the osteoblastic osteosarcoma cell line ROS 17/2.8.
Endocrinology 116:170-179(1985)

PubMed=2325669; DOI=10.1210/mend-4-1-69
Atkinson M.J., Freeman M.W., Kronenberg H.M.
Thymosin beta 4 is expressed in ROS 17/2.8 osteosarcoma cells in a regulated manner.
Mol. Endocrinol. 4:69-74(1990)

PubMed=8456584; DOI=10.1002/jbmr.5650080305
Majeska R.J., Port M., Einhorn T.A.
Attachment to extracellular matrix molecules by cells differing in the expression of osteoblastic traits.
J. Bone Miner. Res. 8:277-289(1993)

PubMed=7988420; DOI=10.1210/endo.135.6.7988420
Williams G.R., Bland R., Sheppard M.C.
Characterization of thyroid hormone (T3) receptors in three osteosarcoma cell lines of distinct osteoblast phenotype: interactions among T3, vitamin D3, and retinoid signaling.
Endocrinology 135:2375-2385(1994)

PubMed=9028534; DOI=10.1016/S8756-3282(96)00337-7
Guignandon A., Genty C., Vico L., Lafage-Proust M.-H., Palle S., Alexandre C.
Demonstration of feasibility of automated osteoblastic line culture in space flight.
Bone 20:109-116(1997)

PubMed=9344586; DOI=10.1006/excr.1997.3703
Guignandon A., Usson Y., Laroche N., Lafage-Proust M.-H., Sabido O., Alexandre C., Vico L.
Effects of intermittent or continuous gravitational stresses on cell-matrix adhesion: quantitative analysis of focal contacts in osteoblastic ROS 17/2.8 cells.
Exp. Cell Res. 236:66-75(1997)

PubMed=11511518; DOI=10.1096/fj.00-0837fje
Guignandon A., Lafage-Proust M.-H., Usson Y., Laroche N., Caillot-Augusseau A., Alexandre C., Vico L.
Cell cycling determines integrin-mediated adhesion in osteoblastic ROS 17/2.8 cells exposed to space-related conditions.
FASEB J. 15:2036-2038(2001)

Dai Z.-Q., Li Y.-H., Ding B., Zhang X.-Y., Tan Y.-J., Wan Y.-M.
Actin microfilaments participate in the regulation of the COL1A1 promoter activity in ROS17/2.8 cells under simulated microgravity.
Adv. Space Res. 38:1159-1167(2006)

Cell line databases/resources MCCL; MCC:0000405
TOKU-E; 3659
Anatomy/cell type resources BTO; BTO:0002648
Encyclopedic resources Wikidata; Q54950823
Entry history
Entry creation04-Apr-2012
Last entry update29-Jun-2023
Version number15