ID   ROS 17/2.8
AC   CVCL_0508
SY   ROS 17/28; Ros 17/2.8; ROS-17/2.8; ROS17/28; ROS17/2.8
DR   BTO; BTO_0002648
DR   EFO; EFO_0022809
DR   MCCL; MCC:0000405
DR   TOKU-E; 3659
DR   Wikidata; Q54950823
RX   DOI=10.1016/j.asr.2006.02.060;
RX   PubMed=2325669;
RX   PubMed=3855255;
RX   PubMed=7988420;
RX   PubMed=8456584;
RX   PubMed=9028534;
RX   PubMed=9344586;
RX   PubMed=11511518;
CC   Group: Space-flown cell line (cellonaut).
CC   Anecdotal: Have been flown in space on Cosmos-2229 (Bion-10), Foton-11 and Foton-12 to study growth and cytoskeletal changes in microgravity (PubMed=9028534; PubMed=11511518).
CC   Derived from site: In situ; Bone; UBERON=UBERON_0002481.
CC   Breed/subspecies: ACI/N; RS=RS_0000023.
DI   NCIt; C60487; Rat osteosarcoma
OX   NCBI_TaxID=10116; ! Rattus norvegicus (Rat)
HI   CVCL_IR39 ! ROS 17/2
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 18
CH   CVCL_U259 ! ROS 17/2.8-5
//
RX   PubMed=8456584; DOI=10.1002/jbmr.5650080305;
RA   Majeska, Robert J.
RA   Port, Michael
RA   Einhorn, Thomas A.
RT   "Attachment to extracellular matrix molecules by cells differing in
RT   the expression of osteoblastic traits.";
RL   J. Bone Miner. Res. 8:277-289(1993).
//
RX   DOI=10.1016/j.asr.2006.02.060;
RA   Dai, Zhong-Quan
RA   Li, Ying-Hui
RA   Ding, Bai
RA   Zhang, Xiao-You
RA   Tan, Ying-Jun
RA   Wan, Yu-Min
RT   "Actin microfilaments participate in the regulation of the COL1A1
RT   promoter activity in ROS17/2.8 cells under simulated microgravity.";
RL   Adv. Space Res. 38:1159-1167(2006).
//
RX   PubMed=11511518; DOI=10.1096/fj.00-0837fje;
RA   Guignandon, Alain
RA   Lafage-Proust, Marie-Helene
RA   Usson, Yves
RA   Laroche, Norbert
RA   Caillot-Augusseau, Anne
RA   Alexandre, Christian
RA   Vico, Laurence
RT   "Cell cycling determines integrin-mediated adhesion in osteoblastic
RT   ROS 17/2.8 cells exposed to space-related conditions.";
RL   FASEB J. 15:2036-2038(2001).
//
RX   PubMed=9344586; DOI=10.1006/excr.1997.3703;
RA   Guignandon, Alain
RA   Usson, Yves
RA   Laroche, Norbert
RA   Lafage-Proust, Marie-Helene
RA   Sabido, Odile
RA   Alexandre, Christian
RA   Vico, Laurence
RT   "Effects of intermittent or continuous gravitational stresses on
RT   cell-matrix adhesion: quantitative analysis of focal contacts in
RT   osteoblastic ROS 17/2.8 cells.";
RL   Exp. Cell Res. 236:66-75(1997).
//
RX   PubMed=7988420; DOI=10.1210/endo.135.6.7988420;
RA   Williams, Graham Richard
RA   Bland, Rosemary
RA   Sheppard, Michael Charles
RT   "Characterization of thyroid hormone (T3) receptors in three
RT   osteosarcoma cell lines of distinct osteoblast phenotype: interactions
RT   among T3, vitamin D3, and retinoid signaling.";
RL   Endocrinology 135:2375-2385(1994).
//
RX   PubMed=3855255; DOI=10.1210/endo-116-1-170;
RA   Majeska, Robert J.
RA   Nair, Bala Chandran
RA   Rodan, Gideon Alfred
RT   "Glucocorticoid regulation of alkaline phosphatase in the osteoblastic
RT   osteosarcoma cell line ROS 17/2.8.";
RL   Endocrinology 116:170-179(1985).
//
RX   PubMed=2325669; DOI=10.1210/mend-4-1-69;
RA   Atkinson, Michael John
RA   Freeman, Mason Wright
RA   Kronenberg, Henry Morris
RT   "Thymosin beta 4 is expressed in ROS 17/2.8 osteosarcoma cells in a
RT   regulated manner.";
RL   Mol. Endocrinol. 4:69-74(1990).
//
RX   PubMed=9028534; DOI=10.1016/S8756-3282(96)00337-7;
RA   Guignandon, Alain
RA   Genty, Christian
RA   Vico, Laurence
RA   Lafage-Proust, Marie-Helene
RA   Palle, Sabine
RA   Alexandre, Christian
RT   "Demonstration of feasibility of automated osteoblastic line culture
RT   in space flight.";
RL   Bone 20:109-116(1997).
//