ID   ROS 17/2.8
AC   CVCL_0508
SY   ROS 17/28; Ros 17/2.8; ROS-17/2.8; ROS17/28; ROS17/2.8
DR   BTO; BTO:0002648
DR   MCCL; MCC:0000405
DR   TOKU-E; 3659
DR   Wikidata; Q54950823
RX   DOI=10.1016/j.asr.2006.02.060;
RX   PubMed=2325669;
RX   PubMed=3855255;
RX   PubMed=7988420;
RX   PubMed=8456584;
RX   PubMed=9028534;
RX   PubMed=9344586;
RX   PubMed=11511518;
CC   Group: Space-flown cell line (cellonaut).
CC   Anecdotal: Have been flown in space on Cosmos-2229 (Bion-10), Foton-11 and Foton-12 to study growth and cytoskeletal changes in microgravity (PubMed=9028534; PubMed=11511518).
CC   Derived from site: In situ; Bone; UBERON=UBERON_0002481.
CC   Breed/subspecies: ACI 9935.
DI   NCIt; C60487; Rat osteosarcoma
OX   NCBI_TaxID=10116; ! Rattus norvegicus (Rat)
HI   CVCL_IR39 ! ROS 17/2
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 29-06-23; Version: 15
//
RX   DOI=10.1016/j.asr.2006.02.060;
RA   Dai Z.-Q., Li Y.-H., Ding B., Zhang X.-Y., Tan Y.-J., Wan Y.-M.;
RT   "Actin microfilaments participate in the regulation of the COL1A1
RT   promoter activity in ROS17/2.8 cells under simulated microgravity.";
RL   Adv. Space Res. 38:1159-1167(2006).
//
RX   PubMed=2325669; DOI=10.1210/mend-4-1-69;
RA   Atkinson M.J., Freeman M.W., Kronenberg H.M.;
RT   "Thymosin beta 4 is expressed in ROS 17/2.8 osteosarcoma cells in a
RT   regulated manner.";
RL   Mol. Endocrinol. 4:69-74(1990).
//
RX   PubMed=3855255; DOI=10.1210/endo-116-1-170;
RA   Majeska R.J., Nair B.C., Rodan G.A.;
RT   "Glucocorticoid regulation of alkaline phosphatase in the osteoblastic
RT   osteosarcoma cell line ROS 17/2.8.";
RL   Endocrinology 116:170-179(1985).
//
RX   PubMed=7988420; DOI=10.1210/endo.135.6.7988420;
RA   Williams G.R., Bland R., Sheppard M.C.;
RT   "Characterization of thyroid hormone (T3) receptors in three
RT   osteosarcoma cell lines of distinct osteoblast phenotype: interactions
RT   among T3, vitamin D3, and retinoid signaling.";
RL   Endocrinology 135:2375-2385(1994).
//
RX   PubMed=8456584; DOI=10.1002/jbmr.5650080305;
RA   Majeska R.J., Port M., Einhorn T.A.;
RT   "Attachment to extracellular matrix molecules by cells differing in
RT   the expression of osteoblastic traits.";
RL   J. Bone Miner. Res. 8:277-289(1993).
//
RX   PubMed=9028534; DOI=10.1016/S8756-3282(96)00337-7;
RA   Guignandon A., Genty C., Vico L., Lafage-Proust M.-H., Palle S.,
RA   Alexandre C.;
RT   "Demonstration of feasibility of automated osteoblastic line culture
RT   in space flight.";
RL   Bone 20:109-116(1997).
//
RX   PubMed=9344586; DOI=10.1006/excr.1997.3703;
RA   Guignandon A., Usson Y., Laroche N., Lafage-Proust M.-H., Sabido O.,
RA   Alexandre C., Vico L.;
RT   "Effects of intermittent or continuous gravitational stresses on
RT   cell-matrix adhesion: quantitative analysis of focal contacts in
RT   osteoblastic ROS 17/2.8 cells.";
RL   Exp. Cell Res. 236:66-75(1997).
//
RX   PubMed=11511518; DOI=10.1096/fj.00-0837fje;
RA   Guignandon A., Lafage-Proust M.-H., Usson Y., Laroche N.,
RA   Caillot-Augusseau A., Alexandre C., Vico L.;
RT   "Cell cycling determines integrin-mediated adhesion in osteoblastic
RT   ROS 17/2.8 cells exposed to space-related conditions.";
RL   FASEB J. 15:2036-2038(2001).
//