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Cellosaurus RBE4 (CVCL_0495)

[Text version]
Cell line name RBE4
Synonyms RBE-4; Rat Brain Endothelial 4
Accession CVCL_0495
Resource Identification Initiative To cite this cell line use: RBE4 (RRID:CVCL_0495)
Comments Group: Patented cell line.
Registration: International Depositary Authority, Pasteur Institute Collection Nationale de Cultures de Micro-organismes (CNCM); I-1142.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P03254; Adenovirus 2 E1A protein.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Transformant: NCBI_TaxID; 10515; Adenovirus 2.
Caution: Indicated as originating from a Sprague-Dawley rat in PubMed=7908023 and from a Lewis rat in Patent=WO1993006222A1.
Derived from site: In situ; Brain, endothelium; UBERON=UBERON_0013694.
Cell type: Brain microvascular endothelial cell; CL=CL_2000044.
Species of origin Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)
Breed/subspecies: Sprague Dawley; RS=RS:0000681.
Sex of cell Sex unspecified
Age at sampling 3M
Category Transformed cell line
Publications

Patent=WO1993006222A1
Claire M., Couraud P.-O., Durieu-Trautmann O., Chaverot N., Roux F., Strosberg A.D.
Immortalized cerebral endothelial cell lines, process for their preparation and applications thereof as a model for the study of cerebral physiopathology.
Patent number WO1993006222A1, 01-Apr-1993

PubMed=7908023; DOI=10.1002/jcp.1041590114
Roux F., Durieu-Trautmann O., Chaverot N., Claire M., Mailly P., Bourre J.-M., Strosberg A.D., Couraud P.-O.
Regulation of gamma-glutamyl transpeptidase and alkaline phosphatase activities in immortalized rat brain microvessel endothelial cells.
J. Cell. Physiol. 159:101-113(1994)

PubMed=12164376; DOI=10.1080/10611860290031930
Reichel A., Abbott N.J., Begley D.J.
Evaluation of the RBE4 cell line to explore carrier-mediated drug delivery to the CNS via the L-system amino acid transporter at the blood-brain barrier.
J. Drug Target. 10:277-283(2002)

PubMed=12958429; DOI=10.1385/1-59259-419-0:307
Reichel A., Begley D.J., Abbott N.J.
An overview of in vitro techniques for blood-brain barrier studies.
Methods Mol. Med. 89:307-324(2003)

Cross-references
Cell line databases/resources MCCL; MCC:0000392
Chemistry resources ChEMBL-Cells; CHEMBL4295418
ChEMBL-Targets; CHEMBL4296491
PubChem_Cell_line; CVCL_0495
Encyclopedic resources Wikidata; Q54949337
Entry history
Entry creation04-Apr-2012
Last entry update10-Sep-2024
Version number12