ID   RBE4
AC   CVCL_0495
SY   RBE-4; Rat Brain Endothelial 4
DR   MCCL; MCC:0000392
DR   ChEMBL-Cells; CHEMBL4295418
DR   ChEMBL-Targets; CHEMBL4296491
DR   PubChem_Cell_line; CVCL_0495
DR   Wikidata; Q54949337
RX   Patent=WO1993006222A1;
RX   PubMed=7908023;
RX   PubMed=12164376;
RX   PubMed=12958429;
CC   Group: Patented cell line.
CC   Registration: International Depositary Authority, Pasteur Institute Collection Nationale de Cultures de Micro-organismes (CNCM); I-1142.
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P03254; Human adenovirus C serotype 2 E1A protein.
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
CC   Transformant: NCBI_TaxID; 10515; Human adenovirus C serotype 2.
CC   Caution: Indicated as originating from a Sprague Dawley rat in PubMed=7908023 and from a Lewis rat in Patent=WO1993006222A1.
CC   Derived from site: In situ; Brain, endothelium; UBERON=UBERON_0013694.
CC   Cell type: Brain microvascular endothelial cell; CL=CL_2000044.
CC   Breed/subspecies: Sprague Dawley; RS=RS_0000681.
OX   NCBI_TaxID=10116; ! Rattus norvegicus (Rat)
SX   Sex unspecified
AG   3M
CA   Transformed cell line
DT   Created: 04-04-12; Last updated: 14-08-25; Version: 14
//
RX   Patent=WO1993006222A1;
RA   Claire, Michel
RA   Couraud, Pierre-Olivier
RA   Durieu-Trautmann, Odile
RA   Chaverot, Nathalie
RA   Roux, Francoise
RA   Strosberg, Arthur Donny
RT   "Immortalized cerebral endothelial cell lines, process for their
RT   preparation and applications thereof as a model for the study of
RT   cerebral physiopathology.";
RL   Patent number WO1993006222A1, 01-Apr-1993.
//
RX   PubMed=12164376; DOI=10.1080/10611860290031930;
RA   Reichel, Andreas
RA   Abbott, N. Joan
RA   Begley, David J.
RT   "Evaluation of the RBE4 cell line to explore carrier-mediated drug
RT   delivery to the CNS via the L-system amino acid transporter at the
RT   blood-brain barrier.";
RL   J. Drug Target. 10:277-283(2002).
//
RX   PubMed=7908023; DOI=10.1002/jcp.1041590114;
RA   Roux, Francoise
RA   Durieu-Trautmann, Odile
RA   Chaverot, Nathalie
RA   Claire, Michel
RA   Mailly, Philippe
RA   Bourre, Jean-Marie
RA   Strosberg, Arthur Donny
RA   Couraud, Pierre-Olivier
RT   "Regulation of gamma-glutamyl transpeptidase and alkaline phosphatase
RT   activities in immortalized rat brain microvessel endothelial cells.";
RL   J. Cell. Physiol. 159:101-113(1994).
//
RX   PubMed=12958429; DOI=10.1385/1-59259-419-0:307;
RA   Reichel, Andreas
RA   Begley, David J.
RA   Abbott, N. Joan
RT   "An overview of in vitro techniques for blood-brain barrier studies.";
RL   Methods Mol. Med. 89:307-324(2003).
//