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Cellosaurus OK (CVCL_0472)

[Text version]
Cell line name OK
Synonyms Opossum Kidney; OK-WT
Accession CVCL_0472
Resource Identification Initiative To cite this cell line use: OK (RRID:CVCL_0472)
Comments Group: Marsupial cell line.
Characteristics: Used to study X chromosome inactivation as well as to investigate proximal tubule ion transport and membrane trafficking.
Doubling time: 18 hours (PubMed=566717).
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Kidney, proximal tubule; UBERON=UBERON_0004134.
Cell type: Epithelial cell of proximal tubule; CL=CL_0002306.
Species of origin Didelphis virginiana (North American opossum) (Didelphis marsupialis virginiana) (NCBI Taxonomy: 9267)
Hierarchy Children:
Sex of cell Female
Age at sampling Adult
Category Spontaneously immortalized cell line
Web pages https://en.wikipedia.org/wiki/OK_cells

PubMed=566717; DOI=10.1007/BF02616032
Koyama H., Goodpasture C., Miller M.M., Teplitz R.L., Riggs A.D.
Establishment and characterization of a cell line from the American opossum (Didelphys virginiana).
In Vitro 14:239-246(1978)

Esposito D.
Cytogenetic and mutagenic studies with an opossum cell line (Didelphys virginiana).
Thesis PhD (1982), Fordham University, United States

PubMed=6394469; DOI=10.1007/BF02619628
Keith D.H., Teplitz R.L., Riggs A.D.
Metaphase synchronization and chromosome preparation from the OK opossum cell line having a potentially isolatable X chromosome.
In Vitro 20:833-836(1984)

PubMed=1802405; DOI=10.1016/0309-1651(91)90094-Y
Courjault F., Gerin B., Leroy D., Chevalier J., Toutain H.
Morphological and biochemical characterization of the opossum kidney cell line and primary cultures of rabbit proximal tubule cells in serum-free defined medium.
Cell Biol. Int. Rep. 15:1225-1234(1991)

PubMed=28615248; DOI=10.1152/ajprenal.00228.2017
Eshbach M.L., Sethi R., Avula R., Lamb J., Hollingshead D.J., Finegold D.N., Locker J.D., Chandran U.R., Weisz O.A.
The transcriptome of the Didelphis virginiana opossum kidney OK proximal tubule cell line.
Am. J. Physiol. Renal Physiol. 313:F585-F595(2017)

PubMed=30379374; DOI=10.1113/EP087217
Guillen N., Caldas Y.A., Levi M., Sorribas V.
Identification and expression analysis of type II and type III Pi transporters in the opossum kidney cell line.
Exp. Physiol. 104:149-161(2019)

PubMed=33122286; DOI=10.1681/ASN.2020010009
Khundmiri S.J., Chen L.-H., Lederer E.D., Yang C.-R., Knepper M.A.
Transcriptomes of major proximal tubule cell culture models.
J. Am. Soc. Nephrol. 32:86-97(2021)

Cell line collections (Providers) ATCC; CRL-1840
CLS; 606465
ECACC; 91021202
KCB; KCB 200824YJ
Cell line databases/resources CLO; CLO_0008246
MCCL; MCC:0000370
CLDB; cl3766
TOKU-E; 2794
Anatomy/cell type resources BTO; BTO:0003069
Encyclopedic resources Wikidata; Q25326634
Gene expression databases GEO; GSM4009046
GEO; GSM4249049
GEO; GSM4249050
GEO; GSM4249051
GEO; GSM4009050
GEO; GSM4009051
GEO; GSM4009052
Entry history
Entry creation04-Apr-2012
Last entry update29-Jun-2023
Version number27