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Cellosaurus OK (CVCL_0472)

[Text version]
Cell line name OK
Synonyms Opossum Kidney; OK-WT
Accession CVCL_0472
Resource Identification Initiative To cite this cell line use: OK (RRID:CVCL_0472)
Comments Group: Marsupial cell line.
Characteristics: Used to study X chromosome inactivation as well as to investigate proximal tubule ion transport and membrane trafficking.
Doubling time: 18 hours (PubMed=566717).
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Kidney, proximal tubule; UBERON=UBERON_0004134.
Cell type: Epithelial cell of proximal tubule; CL=CL_0002306.
Species of origin Didelphis virginiana (North American opossum) (Didelphis marsupialis virginiana) (NCBI Taxonomy: 9267)
Hierarchy Children:
CVCL_W411 (OK7A)CVCL_D041 (OKB)CVCL_D042 (OKH)
CVCL_D040 (OKP)
Sex of cell Female
Age at sampling Adult
Category Spontaneously immortalized cell line
Web pages Info; Evident; -; https://evidentscientific.com/en/microscope-resource/image-gallery/confocal/epithelialindex
Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/o/cell-lines-detail-497.html
Info; Wikipedia; -; https://en.wikipedia.org/wiki/OK_cells
Publications

PubMed=566717; DOI=10.1007/BF02616032
Hideki Koyama, Carll Goodpasture, Marcia Madsen Miller, Raymond L. Teplitz, Arthur Dale Riggs;
Establishment and characterization of a cell line from the American opossum (Didelphys virginiana).
In Vitro 14:239-246(1978)

CLPUB00465
Diane Esposito;
Cytogenetic and mutagenic studies with an opossum cell line (Didelphys virginiana).
Thesis PhD (1982); Fordham University; New York; USA

PubMed=6394469; DOI=10.1007/BF02619628
Douglas H. Keith, Raymond L. Teplitz, Arthur Dale Riggs;
Metaphase synchronization and chromosome preparation from the OK opossum cell line having a potentially isolatable X chromosome.
In Vitro 20:833-836(1984)

PubMed=1802405; DOI=10.1016/0309-1651(91)90094-Y
Francoise Courjault-Gautier, Brigitte Gerin, Danielle Leroy, Jacques Chevalier, Herd Toutain;
Morphological and biochemical characterization of the opossum kidney cell line and primary cultures of rabbit proximal tubule cells in serum-free defined medium.
Cell Biol. Int. Rep. 15:1225-1234(1991)

PubMed=28615248; DOI=10.1152/ajprenal.00228.2017; PMCID=PMC5625107
Megan L. Eshbach, Rahil Sethi, Raghunandan Avula, Janette Lamb, Deborah J. Hollingshead, David N. Finegold, Joseph D. Locker, Uma R. Chandran, Ora A. Weisz;
The transcriptome of the Didelphis virginiana opossum kidney OK proximal tubule cell line.
Am. J. Physiol. Renal Physiol. 313:F585-F595(2017)

PubMed=30379374; DOI=10.1113/EP087217
Natalia Guillen, Yupanqui A. Caldas, Moshe Levi, Victor Sorribas;
Identification and expression analysis of type II and type III Pi transporters in the opossum kidney cell line.
Exp. Physiol. 104:149-161(2019)

PubMed=33122286; DOI=10.1681/ASN.2020010009; PMCID=PMC7894662
Syed J. Khundmiri, Li-He Chen, Eleanor D. Lederer, Chin-Rang Yang, Mark A. Knepper;
Transcriptomes of major proximal tubule cell culture models.
J. Am. Soc. Nephrol. 32:86-97(2021)

Cross-references
Cell line collections (Providers) ATCC; CRL-1840
CLS; 606465
ECACC; 91021202
KCB; KCB 200824YJ
Cell line databases/resources CLO; CLO_0008246
MCCL; MCC:0000370
CLDB; cl3766
CCRID; 3101MAMGNO20
TOKU-E; 2794
Anatomy/cell type resources BTO; BTO_0003069
Encyclopedic resources Wikidata; Q25326634
Gene expression databases GEO; GSM4009046
GEO; GSM4009050
GEO; GSM4009051
GEO; GSM4009052
GEO; GSM4249049
GEO; GSM4249050
GEO; GSM4249051
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number29