AC   CVCL_0472
SY   Opossum Kidney; OK-WT
DR   BTO; BTO:0003069
DR   CLO; CLO_0008246
DR   MCCL; MCC:0000370
DR   CLDB; cl3766
DR   ATCC; CRL-1840
DR   CLS; 606465
DR   ECACC; 91021202
DR   GEO; GSM4009046
DR   GEO; GSM4249049
DR   GEO; GSM4249050
DR   GEO; GSM4249051
DR   GEO; GSM4009050
DR   GEO; GSM4009051
DR   GEO; GSM4009052
DR   KCB; KCB 200824YJ
DR   TOKU-E; 2794
DR   Wikidata; Q25326634
RX   CelloPub=CLPUB00465;
RX   PubMed=566717;
RX   PubMed=1802405;
RX   PubMed=6394469;
RX   PubMed=28615248;
RX   PubMed=30379374;
RX   PubMed=33122286;
CC   Group: Marsupial cell line.
CC   Characteristics: Used to study X chromosome inactivation as well as to investigate proximal tubule ion transport and membrane trafficking.
CC   Doubling time: 18 hours (PubMed=566717).
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: In situ; Kidney, proximal tubule; UBERON=UBERON_0004134.
CC   Cell type: Epithelial cell of proximal tubule; CL=CL_0002306.
OX   NCBI_TaxID=9267; ! Didelphis virginiana (North American opossum)
SX   Female
AG   Adult
CA   Spontaneously immortalized cell line
DT   Created: 04-04-12; Last updated: 29-06-23; Version: 27
RX   CelloPub=CLPUB00465;
RA   Esposito D.;
RT   "Cytogenetic and mutagenic studies with an opossum cell line
RT   (Didelphys virginiana).";
RL   Thesis PhD (1982), Fordham University, United States.
RX   PubMed=566717; DOI=10.1007/BF02616032;
RA   Koyama H., Goodpasture C., Miller M.M., Teplitz R.L., Riggs A.D.;
RT   "Establishment and characterization of a cell line from the American
RT   opossum (Didelphys virginiana).";
RL   In Vitro 14:239-246(1978).
RX   PubMed=1802405; DOI=10.1016/0309-1651(91)90094-Y;
RA   Courjault F., Gerin B., Leroy D., Chevalier J., Toutain H.;
RT   "Morphological and biochemical characterization of the opossum kidney
RT   cell line and primary cultures of rabbit proximal tubule cells in
RT   serum-free defined medium.";
RL   Cell Biol. Int. Rep. 15:1225-1234(1991).
RX   PubMed=6394469; DOI=10.1007/BF02619628;
RA   Keith D.H., Teplitz R.L., Riggs A.D.;
RT   "Metaphase synchronization and chromosome preparation from the OK
RT   opossum cell line having a potentially isolatable X chromosome.";
RL   In Vitro 20:833-836(1984).
RX   PubMed=28615248; DOI=10.1152/ajprenal.00228.2017;
RA   Eshbach M.L., Sethi R., Avula R., Lamb J., Hollingshead D.J.,
RA   Finegold D.N., Locker J.D., Chandran U.R., Weisz O.A.;
RT   "The transcriptome of the Didelphis virginiana opossum kidney OK
RT   proximal tubule cell line.";
RL   Am. J. Physiol. Renal Physiol. 313:F585-F595(2017).
RX   PubMed=30379374; DOI=10.1113/EP087217;
RA   Guillen N., Caldas Y.A., Levi M., Sorribas V.;
RT   "Identification and expression analysis of type II and type III Pi
RT   transporters in the opossum kidney cell line.";
RL   Exp. Physiol. 104:149-161(2019).
RX   PubMed=33122286; DOI=10.1681/ASN.2020010009;
RA   Khundmiri S.J., Chen L.-H., Lederer E.D., Yang C.-R., Knepper M.A.;
RT   "Transcriptomes of major proximal tubule cell culture models.";
RL   J. Am. Soc. Nephrol. 32:86-97(2021).