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Cellosaurus ML-1 [Human leukemia] (CVCL_0436)

[Text version]
Cell line name ML-1 [Human leukemia]
Synonyms ML1
Accession CVCL_0436
Resource Identification Initiative To cite this cell line use: ML-1 [Human leukemia] (RRID:CVCL_0436)
Comments Population: Caucasian.
Microsatellite instability: Stable (MSS) (PubMed=10739008; PubMed=11226526).
Omics: Proteomics; PTM; Phosphorylation; Quantitative.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Disease Adult acute myeloid leukemia (NCIt: C9154)
Acute myeloid leukemia (ORDO: Orphanet_519)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_1418 ! ML-2
CVCL_H526 ! ML-3
Sex of cell Male
Age at sampling 26Y
Category Cancer cell line
STR profile Source(s): COG; ECACC=88113007

Markers:
AmelogeninX
CSF1PO10,11
D2S133816,17
D3S135815
D5S81812
D7S8209,11
D8S11798,13
D13S3179,12
D16S5399,12
D18S5114,18
D19S43314
D21S1129
FGA23,25
TH017,9.3
TPOX8,10
vWA16

Run an STR similarity search on this cell line
Publications

PubMed=6091813; DOI=10.1182/blood.V64.5.1059.1059
Antonio Palumbo, Jun Minowada, Jan Erikson, Carlo Maria Croce, Giovanni Rovera;
Lineage infidelity of a human myelogenous leukemia cell line.
Blood 64:1059-1063(1984)

PubMed=3458526
Kazuma Ohyashiki, Junko H. Ohyashiki, Avery Aba Sandberg;
Cytogenetic characterization of putative human myeloblastic leukemia cell lines (ML-1, -2, and -3): origin of the cells.
Cancer Res. 46:3642-3647(1986)

PubMed=1571549; DOI=10.1182/blood.V79.9.2378.2378
Koichi Sugimoto, Hideo Toyoshima, Ryuichi Sakai, Kiyoshi Miyagawa, Koichi Hagiwara, Fuyuki Ishikawa, Fumimaro Takaku, Yoshio Yazaki, Hisamaru Hirai;
Frequent mutations in the p53 gene in human myeloid leukemia cell lines.
Blood 79:2378-2383(1992)

PubMed=7798274; DOI=10.1016/S0021-9258(18)31687-9
France Carrier, Martin L. Smith, Insoo Bae, Katherine E. Kilpatrick, Timothy J. Lansing, Chaw-Yuan Chen, Marcy Engelstein, Stephen H. Friend, W. David Henner, Tona Morgan Gilmer, Michael Barry Kastan, Albert J. Fornace Jr.;
Characterization of human Gadd45, a p53-regulated protein.
J. Biol. Chem. 269:32672-32677(1994)

PubMed=8814454; DOI=10.1002/(SICI)1098-2264(199607)16:3<204::AID-GCC8>3.0.CO;2-2
Matthew P. Strout, Krzysztof Mrozek, Kristiina Heinonen, Sheila N. Jani Sait, Thomas Byron Shows, Peter D. Aplan;
ML-1 cell line lacks a germline MLL locus.
Genes Chromosomes Cancer 16:204-210(1996)

PubMed=9510473; DOI=10.1111/j.1349-7006.1998.tb00476.x; PMCID=PMC5921588
Noriko Hosoya, Akira Hangaishi, Seishi Ogawa, Kiyoshi Miyagawa, Kinuko Mitani, Yoshio Yazaki, Hisamaru Hirai;
Frameshift mutations of the hMSH6 gene in human leukemia cell lines.
Jpn. J. Cancer Res. 89:33-39(1998)

PubMed=10739008; DOI=10.1016/S0145-2126(99)00182-4
Kaoru Inoue, Takashi Kohno, Satoshi Takakura, Yasuhide Hayashi, Hideaki Mizoguchi, Jun Yokota;
Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines.
Leuk. Res. 24:255-262(2000)

DOI=10.1016/B978-0-12-221970-2.50457-5
Hans Gunther Drexler;
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=11226526; DOI=10.1016/S0145-2126(00)00121-1
Kaoru Inoue, Takashi Kohno, Satoshi Takakura, Yasuhide Hayashi, Hideaki Mizoguchi, Jun Yokota;
Corrigendum to: Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines Leukemia Research 24 (2000), 255-262.
Leuk. Res. 25:275-278(2001)

PubMed=21552520; DOI=10.1371/journal.pone.0019169; PMCID=PMC3084268
Ting-Lei Gu, Julie Nardone, Yi Wang, Marc Loriaux, Judit Villen, Sean A. Beausoleil, Meghan Tucker, Jon M. Kornhauser, Jian-Min Ren, Joan MacNeill, Steven P. Gygi, Brian Jay Druker, Michael Charles Heinrich ...Show all 15 authors... , John Rush, Roberto D. Polakiewicz; Show fewer authors
Survey of activated FLT3 signaling in leukemia.
PLoS ONE 6:e19169.1-e19169.10(2011)

PubMed=23955599; DOI=10.1038/ng.2731
Ayana Kon, Lee-Yung Shih, Masashi Minamino, Masashi Sanada, Yuichi Shiraishi, Yasunobu Nagata, Ken-ichi Yoshida, Yusuke Okuno, Masashige Bando, Ryuichiro Nakato, Shumpei Ishikawa, Aiko Sato-Otsubo, Genta Nagae ...Show all 41 authors... , Aiko Nishimoto, Claudia Haferlach, Daniel Nowak, Yusuke Sato, Tamara Alpermann, Masao Nagasaki, Teppei Shimamura, Hiroko Tanaka, Kenichi Chiba, Ryo Yamamoto, Tomoyuki Yamaguchi, Makoto Otsu, Naoshi Obara, Mamiko Sakata-Yanagimoto, Tsuyoshi Nakamaki, Ken Ishiyama, Florian Nolte, Wolf-Karsten Hofmann, Shuichi Miyawaki, Shigeru Chiba, Hiraku Mori, Hiromitsu Nakauchi, Harold Phillip Koeffler, Hiroyuki Aburatani, Torsten Haferlach, Katsuhiko Shirahige, Satoru Miyano, Seishi Ogawa; Show fewer authors
Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms.
Nat. Genet. 45:1232-1237(2013)

Cross-references
Cell line collections (Providers) ECACC; 88113007
Cell line databases/resources CLO; CLO_0007735
MCCL; MCC:0000331
CLDB; cl3489
Cell_Model_Passport; SIDM00440
Anatomy/cell type resources BTO; BTO_0001884
Encyclopedic resources Wikidata; Q54905840
Experimental variables resources EFO; EFO_0022439
Polymorphism and mutation databases Cosmic; 787453
Cosmic; 798669
Cosmic; 919125
Cosmic; 924048
Cosmic; 947369
Cosmic; 994171
Cosmic; 998746
Cosmic; 999727
Cosmic; 1037658
Cosmic; 1078735
Cosmic; 1078738
Cosmic; 1127255
Cosmic; 2089662
Cosmic; 2301563
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number25