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Cellosaurus MDAH 2774 (CVCL_0420)

[Text version]
Cell line name MDAH 2774
Synonyms MDAH-2774; MDAH2774; MDA-H2774; 2774; #2774; OV-2774; OV-CA-2774; SK-2774
Accession CVCL_0420
Resource Identification Initiative To cite this cell line use: MDAH 2774 (RRID:CVCL_0420)
Comments Part of: OCCP ovarian cancer cell line panel.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-10303.
Omics: Proteomics.
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Ascites; UBERON=UBERON_0007795.
Sequence variations
Disease Ovarian endometrioid adenocarcinoma (NCIt: C7979)
Endometrioid carcinoma of ovary (ORDO: Orphanet_454723)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): AddexBio=C0017001/57; ATCC=CRL-10303; PubMed=22710073; PubMed=25230021

Markers:
AmelogeninX
CSF1PO10,11 (PubMed=22710073; PubMed=25230021)
10,14 (AddexBio=C0017001/57; ATCC=CRL-10303)
D2S133819,24
D3S135816,17,18 (PubMed=22710073)
16,18 (PubMed=25230021)
D5S81810,11,12 (PubMed=22710073; PubMed=25230021)
10,12,13 (AddexBio=C0017001/57; ATCC=CRL-10303)
D7S8208,9.3,10.1,11 (AddexBio=C0017001/57; ATCC=CRL-10303)
10,11,11.1 (PubMed=22710073)
10,11,12 (PubMed=25230021)
D8S117914
D13S3178,9 (PubMed=22710073; PubMed=25230021)
8,9,12 (AddexBio=C0017001/57; ATCC=CRL-10303)
D16S53910,11,12 (PubMed=25230021)
10,11,12,14 (AddexBio=C0017001/57; ATCC=CRL-10303)
11,12 (PubMed=22710073)
D18S5114,15
D19S43314
D21S1130,31
FGA23,24 (PubMed=22710073)
24,25 (PubMed=25230021)
Penta D13,14
Penta E13,14
TH016,8
TPOX8 (PubMed=22710073; PubMed=25230021)
8,11 (AddexBio=C0017001/57; ATCC=CRL-10303)
vWA14,16,19,21 (AddexBio=C0017001/57; ATCC=CRL-10303)
14,19 (PubMed=22710073)
15,19 (PubMed=25230021)

Run an STR similarity search on this cell line
Publications

PubMed=719612; DOI=10.1002/1097-0142(197811)42:5<2352::AID-CNCR2820420536>3.0.CO;2-#
Ralph S. Freedman, Eric Pihl, Christine J. Kusyk, Harry Stephen Gallager, Felix Noah Rutledge;
Characterization of an ovarian carcinoma cell line.
Cancer 42:2352-2359(1978)

PubMed=6582512; DOI=10.1073/pnas.81.2.568; PMCID=PMC344720
Michael Jules Mattes, Carlos Cordon-Cardo, John L. Lewis Jr., Lloyd John Old, Kenneth Oliver Lloyd;
Cell surface antigens of human ovarian and endometrial carcinoma defined by mouse monoclonal antibodies.
Proc. Natl. Acad. Sci. U.S.A. 81:568-572(1984)

PubMed=8557231; DOI=10.1006/gyno.1996.0014
Jeffrey S. Skilling, Robert C. Squatrito, Joseph P. Connor, Theodore Niemann, Richard E. Buller;
p53 gene mutation analysis and antisense-mediated growth inhibition of human ovarian carcinoma cell lines.
Gynecol. Oncol. 60:72-80(1996)

PubMed=9698466; DOI=10.1006/gyno.1998.5039
George Larry Maxwell, John I. Risinger, Betty Tong, Heather Shaw, J. Carl Barrett, Andrew Berchuck, P. Andrew Futreal;
Mutation of the PTEN tumor suppressor gene is not a feature of ovarian cancers.
Gynecol. Oncol. 70:13-16(1998)

PubMed=11314036; DOI=10.1038/sj.onc.1204211
Eva Forgacs, Jonathan D. Wren, Craig Kamibayashi, Masashi Kondo, Xie L. Xu, Sanford David Markowitz, Gail E. Tomlinson, Carolyn Y. Muller, Adi F. Gazdar, Harold Ray Garner, John D. Minna;
Searching for microsatellite mutations in coding regions in lung, breast, ovarian and colorectal cancers.
Oncogene 20:1005-1009(2001)

PubMed=11565033; DOI=10.1038/35095068
Kenneth H. Moberg, Daphne W. Bell, Doke C.R. Pronk-Wahrer, Daniel Arie Haber, Iswar K. Hariharan;
Archipelago regulates cyclin E levels in Drosophila and is mutated in human cancer cell lines.
Nature 413:311-316(2001)

PubMed=12068308; DOI=10.1038/nature00766
Helen R. Davies, Graham Robert Bignell, Charles Cox, Philip J. Stephens, Sarah Edkins, Sheila Clegg, Jon W. Teague, Hayley Woffendin, Mathew J. Garnett, William Bottomley, Neil Davis ...Show all 52 authors... , Ed Dicks, Rebecca Ewing, Yvonne Floyd, Kristian Gray, Sarah Hall, Rachel Hawes, Jaime Hughes, Vivian Kosmidou, Andrew Menzies, Catherine Mould, Adrian Parker, Claire Stevens, Stephen Watt, Steven Hooper, Rebecca Wilson, Hiran Jayatilake, Barry Austin Gusterson, Colin S. Cooper, Janet M. Shipley, Darren Hargrave, Kathy Pritchard-Jones, Norman J. Maitland, Georgia Chenevix-Trench, Gregory J. Riggins, Darell Doty Bigner, Giuseppe Palmieri, Antonio Cossu, Adrienne M. Flanagan, Andrew Nicholson, Judy W.C. Ho, Suet Yi Leung, Siu Tsan Yuen, Barbara L. Weber, Hilliard Foster Seigler, Timothy L. Darrow, Hugh F. Paterson, Richard Marais, Christopher John Marshall, Richard Wooster, Michael Rudolf Stratton, P. Andrew Futreal; Show fewer authors
Mutations of the BRAF gene in human cancer.
Nature 417:949-954(2002)

PubMed=15153938; DOI=10.1038/sj.cgt.7700727
Sven Roy Quist, Shan Wang-Gohrke, Tanja Kohler, Rolf Kreienberg, Ingo Bernard Runnebaum;
Cooperative effect of adenoviral p53 gene therapy and standard chemotherapy in ovarian cancer cells independent of the endogenous p53 status.
Cancer Gene Ther. 11:547-554(2004)

PubMed=19288585; DOI=10.1002/elps.200800505; PMCID=PMC2674123
Lan Dai, Chen Li, Kerby Allan Shedden, David E. Misek, David M. Lubman;
Comparative proteomic study of two closely related ovarian endometrioid adenocarcinoma cell lines using cIEF fractionation and pathway analysis.
Electrophoresis 30:1119-1131(2009)

PubMed=22328975; DOI=10.1158/2159-8290.CD-11-0170; PMCID=PMC3274821
Aphrothiti J. Hanrahan, Nikolaus Schultz, Maggie L. Westfal, Rita A. Sakr, Dilip D. Giri, Stefano Scarperi, Manickam Janakiraman, Narciso Olvera, Ellen V. Stevens, Qing-Bai She, Carol Aghajanian ...Show all 20 authors... , Tari A. King, Elisa de Stanchina, David R. Spriggs, Adriana Heguy, Barry Stephen Taylor, Chris Sander, Neal Rosen, Douglas A. Levine, David B. Solit; Show fewer authors
Genomic complexity and AKT dependence in serous ovarian cancer.
Cancer Discov. 2:56-67(2012)

PubMed=22705003; DOI=10.1016/j.humpath.2012.03.011
Munmun Rahman, Kentaro Nakayama, Mohammed Tanjimur Rahman, Naomi Nakayama, Masako Ishikawa, Atsuko Katagiri, Kouji Iida, Satoru Nakayama, Yoshiro Otsuki, Ie-Ming Shih, Kohji Miyazaki;
Clinicopathologic and biological analysis of PIK3CA mutation in ovarian clear cell carcinoma.
Hum. Pathol. 43:2197-2206(2012)

PubMed=22710073; DOI=10.1016/j.ygyno.2012.06.017; PMCID=PMC3432677
Christopher T. Korch, Monique A. Spillman, Twila A. Jackson, Britta M. Jacobsen, Susan K. Murphy, Bruce Arthur Lessey, Virgil Craig Jordan, Andrew Peter Bradford;
DNA profiling analysis of endometrial and ovarian cell lines reveals misidentification, redundancy and contamination.
Gynecol. Oncol. 127:241-248(2012)

PubMed=25230021; DOI=10.1371/journal.pone.0103988; PMCID=PMC4167545
Corine M. Beaufort, Jean C.A. Helmijr, Anna M. Piskorz, Marlous Hoogstraat, Kirsten Ruigrok-Ritstier, Nicolle Besselink, Muhammed Murtaza, Wilfred F.J. van IJcken, Anouk A.J. Heine, Marcel Smid, Marco J. Koudijs ...Show all 14 authors... , James D. Brenton, Els M.J.J. Berns, Jozien Helleman; Show fewer authors
Ovarian cancer cell line panel (OCCP): clinical importance of in vitro morphological subtypes.
PLoS ONE 9:e103988.1-e103988.16(2014)

PubMed=27235858; DOI=10.1016/j.ygyno.2016.05.028; PMCID=PMC4961516
Lidia Hernandez, Marianne K. Kim, L. Tiffany Lyle, Kristen P. Bunch, Carrie D. House, Franklin Ning, Anne M. Noonan, Christina Messineo Annunziata;
Characterization of ovarian cancer cell lines as in vivo models for preclinical studies.
Gynecol. Oncol. 142:332-340(2016)

Cross-references
Cell line collections (Providers) AddexBio; C0017001/57
ATCC; CRL-10303 - Discontinued
BCRJ; 0163 - Discontinued
Cell line databases/resources MCCL; MCC:0000317
cancercelllines; CVCL_0420
Lonza; 1433
Anatomy/cell type resources BTO; BTO_0003942
Chemistry resources ChEMBL-Cells; CHEMBL4483147
ChEMBL-Targets; CHEMBL4483256
PubChem_Cell_line; CVCL_0420
Encyclopedic resources Wikidata; Q54904669
Gene expression databases GEO; GSE27654
GEO; GSM1291124
Polymorphism and mutation databases Cosmic; 724881
Cosmic; 844345
Cosmic; 875291
Cosmic; 897431
Cosmic; 923109
Cosmic; 1044237
Cosmic; 1113282
Cosmic; 1524360
Cosmic; 1708386
Cosmic; 1709262
Cosmic; 2186588
IARC_TP53; 5550
IARC_TP53; 21489
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number36