ID   MDAH 2774
AC   CVCL_0420
SY   MDAH-2774; MDAH2774; MDA-H2774; 2774; #2774; OV-2774; OV-CA-2774; SK-2774
DR   BTO; BTO_0003942
DR   MCCL; MCC:0000317
DR   AddexBio; C0017001/57
DR   ATCC; CRL-10303
DR   BCRJ; 0163
DR   cancercelllines; CVCL_0420
DR   ChEMBL-Cells; CHEMBL4483147
DR   ChEMBL-Targets; CHEMBL4483256
DR   Cosmic; 724881
DR   Cosmic; 844345
DR   Cosmic; 875291
DR   Cosmic; 897431
DR   Cosmic; 923109
DR   Cosmic; 1044237
DR   Cosmic; 1113282
DR   Cosmic; 1524360
DR   Cosmic; 1708386
DR   Cosmic; 1709262
DR   Cosmic; 2186588
DR   GEO; GSE27654
DR   GEO; GSM1291124
DR   IARC_TP53; 5550
DR   IARC_TP53; 21489
DR   Lonza; 1433
DR   PubChem_Cell_line; CVCL_0420
DR   Wikidata; Q54904669
RX   PubMed=719612;
RX   PubMed=6582512;
RX   PubMed=8557231;
RX   PubMed=9698466;
RX   PubMed=11314036;
RX   PubMed=11565033;
RX   PubMed=12068308;
RX   PubMed=15153938;
RX   PubMed=19288585;
RX   PubMed=22328975;
RX   PubMed=22705003;
RX   PubMed=22710073;
RX   PubMed=25230021;
RX   PubMed=27235858;
CC   Part of: OCCP ovarian cancer cell line panel.
CC   Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-10303.
CC   Sequence variation: Mutation; HGNC; HGNC:16712; FBXW7; Simple; c.862-1G>A; Zygosity=Heterozygous; Note=Splice acceptor mutation (PubMed=11565033).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012583; Zygosity=Unspecified (PubMed=12068308; PubMed=22705003).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Unspecified (PubMed=8557231; PubMed=25230021).
CC   Omics: Proteomics.
CC   Omics: Transcriptomics; Microarray.
CC   Discontinued: ATCC; CRL-10303; true.
CC   Discontinued: BCRJ; 0163; probable.
CC   Derived from site: In situ; Ascites; UBERON=UBERON_0007795.
ST   Source(s): AddexBio=C0017001/57; ATCC=CRL-10303; PubMed=22710073; PubMed=25230021
ST   Amelogenin: X
ST   CSF1PO: 10,11 (PubMed=22710073; PubMed=25230021)
ST   CSF1PO: 10,14 (AddexBio=C0017001/57; ATCC=CRL-10303)
ST   D13S317: 8,9 (PubMed=22710073; PubMed=25230021)
ST   D13S317: 8,9,12 (AddexBio=C0017001/57; ATCC=CRL-10303)
ST   D16S539: 10,11,12 (PubMed=25230021)
ST   D16S539: 10,11,12,14 (AddexBio=C0017001/57; ATCC=CRL-10303)
ST   D16S539: 11,12 (PubMed=22710073)
ST   D18S51: 14,15
ST   D19S433: 14
ST   D21S11: 30,31
ST   D2S1338: 19,24
ST   D3S1358: 16,17,18 (PubMed=22710073)
ST   D3S1358: 16,18 (PubMed=25230021)
ST   D5S818: 10,11,12 (PubMed=22710073; PubMed=25230021)
ST   D5S818: 10,12,13 (AddexBio=C0017001/57; ATCC=CRL-10303)
ST   D7S820: 8,9.3,10.1,11 (AddexBio=C0017001/57; ATCC=CRL-10303)
ST   D7S820: 10,11,11.1 (PubMed=22710073)
ST   D7S820: 10,11,12 (PubMed=25230021)
ST   D8S1179: 14
ST   FGA: 23,24 (PubMed=22710073)
ST   FGA: 24,25 (PubMed=25230021)
ST   Penta D: 13,14
ST   Penta E: 13,14
ST   TH01: 6,8
ST   TPOX: 8 (PubMed=22710073; PubMed=25230021)
ST   TPOX: 8,11 (AddexBio=C0017001/57; ATCC=CRL-10303)
ST   vWA: 14,16,19,21 (AddexBio=C0017001/57; ATCC=CRL-10303)
ST   vWA: 14,19 (PubMed=22710073)
ST   vWA: 15,19 (PubMed=25230021)
DI   NCIt; C7979; Ovarian endometrioid adenocarcinoma
DI   ORDO; Orphanet_454723; Endometrioid carcinoma of ovary
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   Age unspecified
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 36
//
RX   PubMed=9698466; DOI=10.1006/gyno.1998.5039;
RA   Maxwell, George Larry
RA   Risinger, John I.
RA   Tong, Betty
RA   Shaw, Heather
RA   Barrett, J. Carl
RA   Berchuck, Andrew
RA   Futreal, P. Andrew
RT   "Mutation of the PTEN tumor suppressor gene is not a feature of
RT   ovarian cancers.";
RL   Gynecol. Oncol. 70:13-16(1998).
//
RX   PubMed=12068308; DOI=10.1038/nature00766;
RA   Davies, Helen R.
RA   Bignell, Graham Robert
RA   Cox, Charles
RA   Stephens, Philip J.
RA   Edkins, Sarah
RA   Clegg, Sheila
RA   Teague, Jon W.
RA   Woffendin, Hayley
RA   Garnett, Mathew J.
RA   Bottomley, William
RA   Davis, Neil
RA   Dicks, Ed
RA   Ewing, Rebecca
RA   Floyd, Yvonne
RA   Gray, Kristian
RA   Hall, Sarah
RA   Hawes, Rachel
RA   Hughes, Jaime
RA   Kosmidou, Vivian
RA   Menzies, Andrew
RA   Mould, Catherine
RA   Parker, Adrian
RA   Stevens, Claire
RA   Watt, Stephen
RA   Hooper, Steven
RA   Wilson, Rebecca
RA   Jayatilake, Hiran
RA   Gusterson, Barry Austin
RA   Cooper, Colin S.
RA   Shipley, Janet M.
RA   Hargrave, Darren
RA   Pritchard-Jones, Kathryn
RA   Maitland, Norman J.
RA   Chenevix-Trench, Georgia
RA   Riggins, Gregory J.
RA   Bigner, Darell Doty
RA   Palmieri, Giuseppe
RA   Cossu, Antonio
RA   Flanagan, Adrienne Margaret
RA   Nicholson, Andrew
RA   Ho, Judy W.C.
RA   Leung, Suet Yi
RA   Yuen, Siu Tsan
RA   Weber, Barbara L.
RA   Seigler, Hilliard Foster
RA   Darrow, Timothy L.
RA   Paterson, Hugh F.
RA   Marais, Richard
RA   Marshall, Christopher John
RA   Wooster, Richard
RA   Stratton, Michael Rudolf
RA   Futreal, P. Andrew
RT   "Mutations of the BRAF gene in human cancer.";
RL   Nature 417:949-954(2002).
//
RX   PubMed=27235858; DOI=10.1016/j.ygyno.2016.05.028; PMCID=PMC4961516;
RA   Hernandez, Lidia
RA   Kim, Marianne K.
RA   Lyle, L. Tiffany
RA   Bunch, Kristen Paige
RA   House, Carrie D.
RA   Ning, Franklin
RA   Noonan, Anne M.
RA   Annunziata, Christina Messineo
RT   "Characterization of ovarian cancer cell lines as in vivo models for
RT   preclinical studies.";
RL   Gynecol. Oncol. 142:332-340(2016).
//
RX   PubMed=22328975; DOI=10.1158/2159-8290.CD-11-0170; PMCID=PMC3274821;
RA   Hanrahan, Aphrothiti J.
RA   Schultz, Nikolaus
RA   Westfal, Maggie L.
RA   Sakr, Rita A.
RA   Giri, Dilip D.
RA   Scarperi, Stefano
RA   Janakiraman, Manickam
RA   Olvera, Narciso
RA   Stevens, Ellen V.
RA   She, Qing-Bai
RA   Aghajanian, Carol
RA   King, Tari Ann
RA   de Stanchina, Elisa
RA   Spriggs, David R.
RA   Heguy, Adriana
RA   Taylor, Barry Stephen
RA   Sander, Chris
RA   Rosen, Neal
RA   Levine, Douglas A.
RA   Solit, David B.
RT   "Genomic complexity and AKT dependence in serous ovarian cancer.";
RL   Cancer Discov. 2:56-67(2012).
//
RX   PubMed=11565033; DOI=10.1038/35095068;
RA   Moberg, Kenneth H.
RA   Bell, Daphne W.
RA   Pronk-Wahrer, Doke C.R.
RA   Haber, Daniel Arie
RA   Hariharan, Iswar K.
RT   "Archipelago regulates cyclin E levels in Drosophila and is mutated in
RT   human cancer cell lines.";
RL   Nature 413:311-316(2001).
//
RX   PubMed=19288585; DOI=10.1002/elps.200800505; PMCID=PMC2674123;
RA   Dai, Lan
RA   Li, Chen
RA   Shedden, Kerby Allan
RA   Misek, David E.
RA   Lubman, David M.
RT   "Comparative proteomic study of two closely related ovarian
RT   endometrioid adenocarcinoma cell lines using cIEF fractionation and
RT   pathway analysis.";
RL   Electrophoresis 30:1119-1131(2009).
//
RX   PubMed=25230021; DOI=10.1371/journal.pone.0103988; PMCID=PMC4167545;
RA   Beaufort, Corine M.
RA   Helmijr, Jean C.A.
RA   Piskorz, Anna M.
RA   Hoogstraat, Marlous
RA   Ruigrok-Ritstier, Kirsten
RA   Besselink, Nicolle
RA   Murtaza, Muhammed
RA   van IJcken, Wilfred F.J.
RA   Heine, Anouk A.J.
RA   Smid, Marcel
RA   Koudijs, Marco J.
RA   Brenton, James D.
RA   Berns, Els M.J.J.
RA   Helleman, Jozien
RT   "Ovarian cancer cell line panel (OCCP): clinical importance of in
RT   vitro morphological subtypes.";
RL   PLoS ONE 9:e103988.1-e103988.16(2014).
//
RX   PubMed=22710073; DOI=10.1016/j.ygyno.2012.06.017; PMCID=PMC3432677;
RA   Korch, Christopher T.
RA   Spillman, Monique Ann
RA   Jackson, Twila A.
RA   Jacobsen, Britta M.
RA   Murphy, Susan K.
RA   Lessey, Bruce Arthur
RA   Jordan, Virgil Craig
RA   Bradford, Andrew Peter
RT   "DNA profiling analysis of endometrial and ovarian cell lines reveals
RT   misidentification, redundancy and contamination.";
RL   Gynecol. Oncol. 127:241-248(2012).
//
RX   PubMed=6582512; DOI=10.1073/pnas.81.2.568; PMCID=PMC344720;
RA   Mattes, Michael Jules
RA   Cordon-Cardo, Carlos
RA   Lewis, John L. Jr.
RA   Old, Lloyd John
RA   Lloyd, Kenneth Oliver
RT   "Cell surface antigens of human ovarian and endometrial carcinoma
RT   defined by mouse monoclonal antibodies.";
RL   Proc. Natl. Acad. Sci. U.S.A. 81:568-572(1984).
//
RX   PubMed=15153938; DOI=10.1038/sj.cgt.7700727;
RA   Quist, Sven Roy
RA   Wang-Gohrke, Shan
RA   Kohler, Tanja
RA   Kreienberg, Rolf
RA   Runnebaum, Ingo Bernard
RT   "Cooperative effect of adenoviral p53 gene therapy and standard
RT   chemotherapy in ovarian cancer cells independent of the endogenous p53
RT   status.";
RL   Cancer Gene Ther. 11:547-554(2004).
//
RX   PubMed=719612; DOI=10.1002/1097-0142(197811)42:5<2352::AID-CNCR2820420536>3.0.CO;2-#;
RA   Freedman, Ralph S.
RA   Pihl, Eric
RA   Kusyk, Christine J.
RA   Gallager, Harry Stephen
RA   Rutledge, Felix Noah
RT   "Characterization of an ovarian carcinoma cell line.";
RL   Cancer 42:2352-2359(1978).
//
RX   PubMed=8557231; DOI=10.1006/gyno.1996.0014;
RA   Skilling, Jeffrey S.
RA   Squatrito, Robert C.
RA   Connor, Joseph P.
RA   Niemann, Theodore
RA   Buller, Richard E.
RT   "p53 gene mutation analysis and antisense-mediated growth inhibition
RT   of human ovarian carcinoma cell lines.";
RL   Gynecol. Oncol. 60:72-80(1996).
//
RX   PubMed=22705003; DOI=10.1016/j.humpath.2012.03.011;
RA   Rahman, Munmun
RA   Nakayama, Kentaro
RA   Rahman, Mohammed Tanjimur
RA   Nakayama, Naomi
RA   Ishikawa, Masako
RA   Katagiri, Atsuko
RA   Iida, Kouji
RA   Nakayama, Satoru
RA   Otsuki, Yoshiro
RA   Shih, Ie-Ming
RA   Miyazaki, Kohji
RT   "Clinicopathologic and biological analysis of PIK3CA mutation in
RT   ovarian clear cell carcinoma.";
RL   Hum. Pathol. 43:2197-2206(2012).
//
RX   PubMed=11314036; DOI=10.1038/sj.onc.1204211;
RA   Forgacs, Eva
RA   Wren, Jonathan D.
RA   Kamibayashi, Craig
RA   Kondo, Masashi
RA   Xu, Xie L.
RA   Markowitz, Sanford David
RA   Tomlinson, Gail E.
RA   Muller, Carolyn Y.
RA   Gazdar, Adi F.
RA   Garner, Harold Ray
RA   Minna, John D.
RT   "Searching for microsatellite mutations in coding regions in lung,
RT   breast, ovarian and colorectal cancers.";
RL   Oncogene 20:1005-1009(2001).
//