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Cellosaurus M059K (CVCL_0401)

[Text version]
Cell line name M059K
Accession CVCL_0401
Resource Identification Initiative To cite this cell line use: M059K (RRID:CVCL_0401)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Caucasian.
Characteristics: Radioresistant (PubMed=7494872).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Proteomics; PTM; Phosphorylation; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Brain; UBERON=UBERON_0000955.
Sequence variations
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Pro204fs*17 (c.610delC); Zygosity=Homozygous (DepMap=ACH-000152).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu286lys (c.856G>A); Zygosity=Homozygous (PubMed=11023613; DepMap=ACH-000152).
HLA typing Source: PubMed=26589293
Class I
HLA-AA*01:01,02:01
HLA-BB*08:01,40:01
HLA-CC*03:04,07:01
Class II
HLA-DQDQA1*02:01,04:01
HLA-DRDRB1*11:01,11:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.16
Native American0
East Asian, North2.3
East Asian, South0
South Asian0
European, North69.38
European, South28.16
Disease Glioblastoma (NCIt: C3058)
Glioblastoma (ORDO: Orphanet_360)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_0400 ! M059J
Sex of cell Male
Age at sampling 33Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-2365; PubMed=25877200

Markers:
AmelogeninX,Y
CSF1PO10,12
D2S133820,24
D3S135814,15
D5S81811,12
D7S82010
D8S117915
D13S31714
D16S53910,12
D18S5115,19
D19S43314
D21S1130,31.2
FGA20,26
Penta D12,13
Penta E7,15
TH019.3
TPOX8
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=8316628; DOI=10.2307/3578196
M. Joan Allalunis-Turner, Geraldine M. Barron, Rufus S. Day 3rd, Kelly D. Dobler, Razmik Mirzayans;
Isolation of two cell lines from a human malignant glioma specimen differing in sensitivity to radiation and chemotherapeutic drugs.
Radiat. Res. 134:349-354(1993)

PubMed=7494872; DOI=10.2307/3578948
M. Joan Allalunis-Turner, Peter K.Y. Zia, Geraldine M. Barron, Razmik Mirzayans, Rufus S. Day 3rd;
Radiation-induced DNA damage and repair in cells of a radiosensitive human malignant glioma cell line.
Radiat. Res. 144:288-293(1995)

PubMed=10629611; DOI=10.1667/0033-7587(2000)153[0125:COTRMC]2.0.CO;2
Bradford S. Hoppe, Ryan B. Jensen, Cordula U. Kirchgessner;
Complementation of the radiosensitive M059J cell line.
Radiat. Res. 153:125-130(2000)

PubMed=11023613; DOI=10.1667/0033-7587(2000)154[0473:HTFTMG]2.0.CO;2
Carl William Anderson, M. Joan Allalunis-Turner;
Human TP53 from the malignant glioma-derived cell lines M059J and M059K has a cancer-associated mutation in exon 8.
Radiat. Res. 154:473-476(2000)

PubMed=12105990; DOI=10.1667/0033-7587(2002)158[0195:DOAGMI]2.0.CO;2
Rika Tsuchida, Takayuki Yamada, Masatoshi Takagi, Akira Shimada, Chikashi Ishioka, Yoko Katsuki, Takashi Igarashi, Luciana Chessa, Domenico Delia, Hirobumi Teraoka, Shuki Mizutani;
Detection of ATM gene mutation in human glioma cell line M059J by a rapid frameshift/stop codon assay in yeast.
Radiat. Res. 158:195-201(2002)

PubMed=18077418; DOI=10.1073/pnas.0707579104; PMCID=PMC2148387
Matthew P. Stokes, John Rush, Joan MacNeill, Jian Min Ren, Kam Sprott, Julie Nardone, Vicky Yang, Sean A. Beausoleil, Steven P. Gygi, Mark Livingstone, Hui Zhang ...Show all 13 authors... , Roberto D. Polakiewicz, Michael J. Comb; Show fewer authors
Profiling of UV-induced ATM/ATR signaling pathways.
Proc. Natl. Acad. Sci. U.S.A. 104:19855-19860(2007)

PubMed=21406405; DOI=10.1158/0008-5472.CAN-10-3112
Michal Grzmil, Pier Morin Jr., Maria Maddalena Lino, Adrian Merlo, Stephan Frank, Yu-Hua Wang, Gerald Moncayo, Brian Arthur Hemmings;
MAP kinase-interacting kinase 1 regulates SMAD2-dependent TGF-beta signaling pathway in human glioblastoma.
Cancer Res. 71:2392-2402(2011)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25485619; DOI=10.1038/nbt.3080
Christiaan Klijn, Steffen Durinck, Eric W. Stawiski, Peter M. Haverty, Zhao-Shi Jiang, Han-Bin Liu, Jeremiah Degenhardt, Oleg Mayba, Florian Gnad, Jin-Feng Liu, Gregoire Pau ...Show all 30 authors... , Jens Reeder, Yi Cao, Kiran Mukhyala, Suresh K. Selvaraj, Ma-Mie Yu, Gregory J. Zynda, Matthew J. Brauer, Thomas D. Wu, Robert Clifford Gentleman, Gerard Manning, Robert L. Yauch, Richard Bourgon, David Stokoe, Zora Modrusan, Richard M. Neve, Frederic J. de Sauvage, Jeffrey Settleman, Somasekar Seshagiri, Ze-Min Zhang; Show fewer authors
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections (Providers) ATCC; CRL-2365
BCRC; 60381
Cell line databases/resources CLO; CLO_0007446
MCCL; MCC:0000295
cancercelllines; CVCL_0401
Cell_Model_Passport; SIDM00639
DepMap; ACH-000152
LINCS_LDP; LCL-1362
Biological sample resources BioSample; SAMN03473046
BioSample; SAMN10987790
CRISP screens repositories BioGRID_ORCS_Cell_line; 559
Chemistry resources PharmacoDB; M059K_878_2019
Encyclopedic resources Wikidata; Q54903416
Experimental variables resources EFO; EFO_0006451
Gene expression databases ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM887286
GEO; GSM888361
GEO; GSM1374641
GEO; GSM1670071
Polymorphism and mutation databases Cosmic; 897445
Cosmic; 1237543
IARC_TP53; 28272
LiGeA; CCLE_918
Progenetix; CVCL_0401
Sequence databases EGA; EGAS00001000610
EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number34