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Cellosaurus LLC-PK1 (CVCL_0391)

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Cell line name LLC-PK1
Synonyms LLC-PK(1); LLC-PK-1; LLC PK-1; LLc-PK1; LLC PK1; LLCPK1; Lilly Laboratories Culture-Porcine Kidney 1
Accession CVCL_0391
Secondary accession CVCL_K238
Resource Identification Initiative To cite this cell line use: LLC-PK1 (RRID:CVCL_0391)
Comments Group: Patented cell line.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CL-101.
Doubling time: ~24 hours (DSMZ=ACC-637).
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
Cell type: Epithelial cell of kidney; CL=CL_0002518.
Species of origin Sus scrofa (Pig) (NCBI Taxonomy: 9823)
Breed/subspecies: Hampshire.
Hierarchy Children:
CVCL_8171 (AOK-B50)CVCL_8172 (AR-C40)CVCL_U206 (LLC-GA5)
CVCL_6331 (LLC-PK1A)
Sex of cell Male
Age at sampling 3-4W
Category Spontaneously immortalized cell line
Web pages https://www.atcc.org/en/support/technical-support/faqs/atcc-cl-101-vs-atcc-cl-101-1

Hull R.N., Tritch O.J.
Characterization of cell strains by viral susceptibility.
Natl. Cancer Inst. Monogr. 7:161-172(1962)

Hull R.N., Huseby R.M.
Enhanced production of plasminogen activator.
Patent number US3904480, 09-Sep-1975

PubMed=828141; DOI=10.1007/BF02797469
Hull R.N., Cherry W.R., Weaver G.W.
The origin and characteristics of a pig kidney cell strain, LLC-PK1.
In Vitro 12:670-677(1976)

PubMed=8097873; DOI=10.1023/A:1018954204094
Hori R., Okuda M., Ohishi Y., Yasuhara M., Inui K.-i., Takano M.
Decreased cellular toxicity of neomycin in a clonal cell line isolated from LLC-PK1.
Pharm. Res. 10:573-576(1993)

PubMed=17389150; DOI=10.1016/j.cbpa.2007.02.005
Pine M.D., Greer K.A., Busbee D.L.
Comparison of reactive oxygen scavenging systems between a cetacean (DKN1) and a porcine renal epithelial cell line (LLC-PK1).
Comp. Biochem. Physiol. 147A:550-555(2007)

PubMed=19508353; DOI=10.1111/j.1744-313X.2009.00853.x
Ho C.S., Franzo-Romain M.H., Lee Y.J., Lee J.H., Smith D.M.
Sequence-based characterization of swine leucocyte antigen alleles in commercially available porcine cell lines.
Int. J. Immunogenet. 36:231-234(2009)

PubMed=20555413; DOI=10.1139/y10-023
Gunness P., Aleksa K., Kosuge K., Ito S., Koren G.
Comparison of the novel HK-2 human renal proximal tubular cell line with the standard LLC-PK1 cell line in studying drug-induced nephrotoxicity.
Can. J. Physiol. Pharmacol. 88:448-455(2010)

PubMed=33122286; DOI=10.1681/ASN.2020010009
Khundmiri S.J., Chen L.-H., Lederer E.D., Yang C.-R., Knepper M.A.
Transcriptomes of major proximal tubule cell culture models.
J. Am. Soc. Nephrol. 32:86-97(2021)

PubMed=34737324; DOI=10.1038/s41598-021-00779-5
Lung O., Candlish R.C., Nebroski M., Kruckiewicz P., Buchanan C., Moniwa M.
High-throughput sequencing for species authentication and contamination detection of 63 cell lines.
Sci. Rep. 11:21657-21657(2021)

Cell line collections (Providers) ABM; T9045
ATCC; CL-101
ATCC; CRL-1392 - Discontinued
BCRC; 60080
BCRJ; 0147
CLS; 607264
ECACC; 86121112
Cell line databases/resources CLO; CLO_0007331
MCCL; MCC:0000286
CLDB; cl3221
CLDB; cl5221
CCRID; 1101SWI-PUMC000111
DSMZCellDive; ACC-637
Lonza; 844
TOKU-E; 2208
Anatomy/cell type resources BTO; BTO:0000760
Chemistry resources ChEMBL-Cells; CHEMBL3307655
ChEMBL-Targets; CHEMBL614577
PubChem_Cell_line; CVCL_0391
Encyclopedic resources Wikidata; Q28334936
Gene expression databases GEO; GSM4009059
GEO; GSM4009060
GEO; GSM4009061
Medical resources MeSH; D018374
Proteomic databases PRIDE; PXD007891
Entry history
Entry creation04-Apr-2012
Last entry update30-Jan-2024
Version number33