ID   LLC-PK1
AC   CVCL_0391
AS   CVCL_K238
SY   LLC-PK(1); LLC-PK-1; LLC PK-1; LLc-PK1; LLC PK1; LLCPK1; Lilly Laboratories Culture-Porcine Kidney 1
DR   BTO; BTO_0000760
DR   CLO; CLO_0007331
DR   MCCL; MCC:0000286
DR   CLDB; cl3221
DR   CLDB; cl5221
DR   ABM; T9045
DR   ATCC; CL-101
DR   ATCC; CRL-1392
DR   BCRC; 60080
DR   BCRJ; 0147
DR   CCRID; 1101SWI-PUMC000111
DR   CCRID; 4201SWI-CCTCC00612
DR   ChEMBL-Cells; CHEMBL3307655
DR   ChEMBL-Targets; CHEMBL614577
DR   CLS; 607264
DR   DSMZ; ACC-637
DR   DSMZCellDive; ACC-637
DR   ECACC; 86121112
DR   EDITGENE; EDC00024
DR   GEO; GSM4009059
DR   GEO; GSM4009060
DR   GEO; GSM4009061
DR   IZSLER; BS CL 111
DR   JCRB; JCRB0060
DR   Lonza; 844
DR   MeSH; D018374
DR   PRIDE; PXD007891
DR   PubChem_Cell_line; CVCL_0391
DR   TOKU-E; 2208
DR   Wikidata; Q28334936
RX   Patent=US3904480;
RX   PubMed=828141;
RX   PubMed=8097873;
RX   PubMed=14449902;
RX   PubMed=17337088;
RX   PubMed=17389150;
RX   PubMed=19508353;
RX   PubMed=20555413;
RX   PubMed=23460964;
RX   PubMed=33122286;
RX   PubMed=34737324;
WW   Info; -; -; https://micro.magnet.fsu.edu/primer/techniques/fluorescence/gallery/cells/llcpk1/llcpk1cells.html
WW   Info; ATCC; -; https://www.atcc.org/en/support/technical-support/faqs/atcc-cl-101-vs-atcc-cl-101-1
WW   Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/l/cell-lines-detail-150.html
CC   Group: Patented cell line.
CC   Registration: International Depositary Authority, American Type Culture Collection (ATCC); CL-101.
CC   Doubling time: 25.7 hours (PubMed=23460964); ~24 hours (DSMZ=ACC-637).
CC   Omics: Transcriptomics; RNAseq.
CC   Discontinued: ATCC; CRL-1392; true.
CC   Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
CC   Cell type: Epithelial cell of kidney; CL=CL_0002518.
CC   Breed/subspecies: Hampshire; VBO=VBO_0001146.
OX   NCBI_TaxID=9823; ! Sus scrofa (Pig)
SX   Male
AG   3-4W
CA   Spontaneously immortalized cell line
DT   Created: 04-04-12; Last updated: 25-06-26; Version: 38
CH   CVCL_8171 ! AOK-B50
CH   CVCL_8172 ! AR-C40
CH   CVCL_F5P3 ! EDITGENE LLC-PK1-Cas9
CH   CVCL_F5Z0 ! EDITGENE LLC-PK1-CopGFP
CH   CVCL_F5RH ! EDITGENE LLC-PK1-FLUC
CH   CVCL_U206 ! LLC-GA5
CH   CVCL_U970 ! LLC-PK1-GR101
CH   CVCL_IJ30 ! LLC-PK1/BCRP
CH   CVCL_IP75 ! LLC-PK1/Cl4
CH   CVCL_B7MP ! LLC-PK1/NRa1
CH   CVCL_B7MQ ! LLC-PK1/NRa3
CH   CVCL_9577 ! LLC-PK10
CH   CVCL_6331 ! LLC-PK1A
//
RX   PubMed=23460964;
RA   Tian, Ye
RA   Qu, Bo-Xuan
RA   Yao, Yan
RA   Zeng, Su
RT   "Establishment of BCRP expressed pig kidney cell line LLC-PK1/BCRP and
RT   its biological profile.";
RL   Yao Xue Xue Bao 47:1599-1604(2012).
//
RX   PubMed=17337088; DOI=10.1016/j.ejcb.2007.01.002;
RA   Tambuyzer, Bart R.
RA   Lambrichts, Ivo
RA   Lenjou, Marc
RA   Nouwen, Etienne J.
RT   "Effects of the pig renal epithelial cell line LLC-PK1 and its
RT   conditioned medium on the phenotype of porcine microglia in vitro.";
RL   Eur. J. Cell Biol. 86:221-232(2007).
//
RX   PubMed=20555413; DOI=10.1139/y10-023;
RA   Gunness, Patricia
RA   Aleksa, Katarina
RA   Kosuge, Kazuhiro
RA   Ito, Shinya
RA   Koren, Gideon
RT   "Comparison of the novel HK-2 human renal proximal tubular cell line
RT   with the standard LLC-PK1 cell line in studying drug-induced
RT   nephrotoxicity.";
RL   Can. J. Physiol. Pharmacol. 88:448-455(2010).
//
RX   PubMed=8097873; DOI=10.1023/A:1018954204094;
RA   Hori, Ryohei
RA   Okuda, Masahiro
RA   Ohishi, Yoshiko
RA   Yasuhara, Masato
RA   Inui, Ken-ichi
RA   Takano, Mikihisa
RT   "Decreased cellular toxicity of neomycin in a clonal cell line
RT   isolated from LLC-PK1.";
RL   Pharm. Res. 10:573-576(1993).
//
RX   PubMed=19508353; DOI=10.1111/j.1744-313X.2009.00853.x;
RA   Ho, Chak-Sum
RA   Franzo-Romain, Megan Hope
RA   Lee, Yu-Joo
RA   Lee, Jun-Heon
RA   Smith, Douglas M.
RT   "Sequence-based characterization of swine leucocyte antigen alleles in
RT   commercially available porcine cell lines.";
RL   Int. J. Immunogenet. 36:231-234(2009).
//
RX   PubMed=33122286; DOI=10.1681/ASN.2020010009; PMCID=PMC7894662;
RA   Khundmiri, Syed J.
RA   Chen, Li-He
RA   Lederer, Eleanor D.
RA   Yang, Chin-Rang
RA   Knepper, Mark A.
RT   "Transcriptomes of major proximal tubule cell culture models.";
RL   J. Am. Soc. Nephrol. 32:86-97(2021).
//
RX   PubMed=34737324; DOI=10.1038/s41598-021-00779-5; PMCID=PMC8569163;
RA   Lung, Oliver
RA   Candlish, Rebecca C.
RA   Nebroski, Michelle
RA   Kruckiewicz, Peter
RA   Buchanan, Cody
RA   Moniwa, Mariko
RT   "High-throughput sequencing for species authentication and
RT   contamination detection of 63 cell lines.";
RL   Sci. Rep. 11:21657.1-21657.9(2021).
//
RX   PubMed=17389150; DOI=10.1016/j.cbpa.2007.02.005;
RA   Pine, Michelle D.
RA   Greer, Kimberly A.
RA   Busbee, David L.
RT   "Comparison of reactive oxygen scavenging systems between a cetacean
RT   (DKN1) and a porcine renal epithelial cell line (LLC-PK1).";
RL   Comp. Biochem. Physiol. 147A:550-555(2007).
//
RX   PubMed=828141; DOI=10.1007/BF02797469;
RA   Hull, Robert N.
RA   Cherry, William R.
RA   Weaver, G.W.
RT   "The origin and characteristics of a pig kidney cell strain, LLC-PK1.";
RL   In Vitro 12:670-677(1976).
//
RX   Patent=US3904480;
RA   Hull, Robert N.
RA   Huseby, Rolf M.
RT   "Enhanced production of plasminogen activator.";
RL   Patent number US3904480, 09-Sep-1975.
//
RX   PubMed=14449902;
RA   Hull, Robert N.
RA   Tritch, O. Jeannette
RT   "Characterization of cell strains by viral susceptibility.";
RL   Natl. Cancer Inst. Monogr. 7:161-172(1962).
//