Cellosaurus logo
expasy logo

Cellosaurus KYN-2 (CVCL_0381)

[Text version]
Cell line name KYN-2
Synonyms KYN2
Accession CVCL_0381
Resource Identification Initiative To cite this cell line use: KYN-2 (RRID:CVCL_0381)
Comments Population: Japanese.
Doubling time: 28 hours (Note=In DMEMA + 10% FBS), 68 hours (Note=In HB101), 42 hours (Note=In CDM medium) (PubMed=2847482).
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
HLA typing Source: PubMed=9178645
Class I
HLA-AA*24:02,24:02
HLA-BB*52:01
HLA-CC*12:02
Class II
HLA-DQDQA1*01:02,03:01
DQB1*04:01,05:02
HLA-DRDRB1*04:05,16:02
Disease Adult hepatocellular carcinoma (NCIt: C7956)
Adult hepatocellular carcinoma (ORDO: Orphanet_210159)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 52Y
Category Cancer cell line
Publications

PubMed=2847482; DOI=10.1111/j.1440-1827.1988.tb02368.x
Hirohisa Yano, Masafumi Maruiwa, Tatsuo Murakami, Kazunori Fukuda, Yuji Ito, Shigetaka Sugihara, Masamichi Kojiro;
A new human pleomorphic hepatocellular carcinoma cell line, KYN-2.
Acta Pathol. Jpn. 38:953-966(1988)

PubMed=7537711; DOI=10.1002/hep.1840210510
Makoto Haramaki, Hirohisa Yano, Kazunori Fukuda, Seiya Momosaki, Sachiko Ogasawara, Masamichi Kojiro;
Expression of CD44 in human hepatocellular carcinoma cell lines.
Hepatology 21:1276-1284(1995)

PubMed=8738480; DOI=10.1007/BF00143361
Amr Abid, Nicole Sabolovic, Jacques Magdalou;
Inducibility of ethoxyresorufin deethylase and UDP-glucuronosyltransferase activities in two human hepatocarcinoma cell lines KYN-2 and Mz-Hep-1.
Cell Biol. Toxicol. 12:115-123(1996)

PubMed=9178645; DOI=10.1006/cimm.1997.1108
Masanobu Nakao, Michio Sata, Hideki Saitsu, Shigeru Yutani, Mayumi Kawamoto, Masamichi Kojiro, Kyogo Itoh;
CD4+ hepatic cancer-specific cytotoxic T lymphocytes in patients with hepatocellular carcinoma.
Cell. Immunol. 177:176-181(1997)

PubMed=10347112; DOI=10.1002/hep.510290624
Hirohisa Yano, Akihiro Iemura, Makoto Haramaki, Sachiko Ogasawara, Akiko Takayama, Jun Akiba, Masamichi Kojiro;
Interferon alfa receptor expression and growth inhibition by interferon alfa in human liver cancer cell lines.
Hepatology 29:1708-1717(1999)

PubMed=27329724; DOI=10.18632/oncotarget.10161; PMCID=PMC5216950
Kosuke Watari, Ayumi Nishitani, Tomohiro Shibata, Masaki Noda, Akihiko Kawahara, Jun Akiba, Yuichi Murakami, Hirohisa Yano, Michihiko Kuwano, Mayumi Ono;
Phosphorylation of mTOR Ser2481 is a key target limiting the efficacy of rapalogs for treating hepatocellular carcinoma.
Oncotarget 7:47403-47417(2016)

Cross-references
Cell line databases/resources MCCL; MCC:0000276
Encyclopedic resources Wikidata; Q54900790
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number15