ID   KYN-2
AC   CVCL_0381
SY   KYN2
DR   MCCL; MCC:0000276
DR   Wikidata; Q54900790
RX   PubMed=2847482;
RX   PubMed=7537711;
RX   PubMed=8738480;
RX   PubMed=9178645;
RX   PubMed=10347112;
RX   PubMed=27329724;
CC   Population: Japanese.
CC   Doubling time: 28 hours (Note=In DMEMA + 10% FBS), 68 hours (Note=In HB101), 42 hours (Note=In CDM medium) (PubMed=2847482).
CC   HLA typing: A*24:02,24:02; B*52:01; C*12:02; DQA1*01:02,03:01; DQB1*04:01,05:02; DRB1*04:05,16:02 (PubMed=9178645).
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
DI   NCIt; C7956; Adult hepatocellular carcinoma
DI   ORDO; Orphanet_210159; Adult hepatocellular carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   52Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 15
//
RX   PubMed=2847482; DOI=10.1111/j.1440-1827.1988.tb02368.x;
RA   Yano H., Maruiwa M., Murakami T., Fukuda K., Ito Y., Sugihara S.,
RA   Kojiro M.;
RT   "A new human pleomorphic hepatocellular carcinoma cell line, KYN-2.";
RL   Acta Pathol. Jpn. 38:953-966(1988).
//
RX   PubMed=7537711; DOI=10.1002/hep.1840210510;
RA   Haramaki M., Yano H., Fukuda K., Momosaki S., Ogasawara S., Kojiro M.;
RT   "Expression of CD44 in human hepatocellular carcinoma cell lines.";
RL   Hepatology 21:1276-1284(1995).
//
RX   PubMed=8738480; DOI=10.1007/BF00143361;
RA   Abid A., Sabolovic N., Magdalou J.;
RT   "Inducibility of ethoxyresorufin deethylase and
RT   UDP-glucuronosyltransferase activities in two human hepatocarcinoma
RT   cell lines KYN-2 and Mz-Hep-1.";
RL   Cell Biol. Toxicol. 12:115-123(1996).
//
RX   PubMed=9178645; DOI=10.1006/cimm.1997.1108;
RA   Nakao M., Sata M., Saitsu H., Yutani S., Kawamoto M., Kojiro M.,
RA   Itoh K.;
RT   "CD4+ hepatic cancer-specific cytotoxic T lymphocytes in patients with
RT   hepatocellular carcinoma.";
RL   Cell. Immunol. 177:176-181(1997).
//
RX   PubMed=10347112; DOI=10.1002/hep.510290624;
RA   Yano H., Iemura A., Haramaki M., Ogasawara S., Takayama A., Akiba J.,
RA   Kojiro M.;
RT   "Interferon alfa receptor expression and growth inhibition by
RT   interferon alfa in human liver cancer cell lines.";
RL   Hepatology 29:1708-1717(1999).
//
RX   PubMed=27329724; DOI=10.18632/oncotarget.10161; PMCID=PMC5216950;
RA   Watari K., Nishitani A., Shibata T., Noda M., Kawahara A., Akiba J.,
RA   Murakami Y., Yano H., Kuwano M., Ono M.;
RT   "Phosphorylation of mTOR Ser2481 is a key target limiting the efficacy
RT   of rapalogs for treating hepatocellular carcinoma.";
RL   Oncotarget 7:47403-47417(2016).
//