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Cellosaurus JAR (CVCL_0360)

[Text version]
Cell line name JAR
Synonyms Jar; JAr; JaR
Accession CVCL_0360
Resource Identification Initiative To cite this cell line use: JAR (RRID:CVCL_0360)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Doubling time: ~20-30 hours (DSMZ=ACC-462).
Karyotypic information: Near triploid karyotype (PubMed=33096371).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Variations; SNP array analysis.
Caution: Established from the trophoblastic tumor of the placenta of a 24 year old woman, but the cell line is from the male fetus.
Genome ancestry Source: PubMed=30894373

Origin% genome
African30.11
Native American0.66
East Asian, North2.4
East Asian, South0
South Asian1.4
European, North42.28
European, South23.14
Disease Gestational choriocarcinoma (NCIt: C4646)
Gestational choriocarcinoma (ORDO: Orphanet_99926)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_XY25 (JAR-G1)CVCL_XY26 (JAR-G1s)CVCL_C8NY (Jar-GnT4a)
CVCL_B7MU (JAR-Smad3/c)
Sex of cell Male
Age at sampling Fetus
Category Cancer cell line
STR profile Source(s): ATCC=HTB-144; CLS=300221; Cosmic-CLP=907175; DSMZ=ACC-462; KCLB=30144

Markers:
AmelogeninX,Y
CSF1PO7,10
D2S133820,21
D3S135814 (CLS=300221)
14,16,17 (DSMZ=ACC-462)
16,17 (ATCC=HTB-144; KCLB=30144)
D5S81810,11
D7S82010,11
D8S117914,16
D13S31711
D16S5399,10
D18S5113,17 (CLS=300221)
14,15 (ATCC=HTB-144; DSMZ=ACC-462)
D19S43312,13
D21S1128,29 (ATCC=HTB-144; DSMZ=ACC-462)
30 (CLS=300221)
FGA22
Penta D9,11 (CLS=300221)
9,14 (ATCC=HTB-144; DSMZ=ACC-462)
Penta E8,12 (ATCC=HTB-144; DSMZ=ACC-462)
10,12 (CLS=300221)
TH016,7
TPOX8,11
vWA16,18

Run an STR similarity search on this cell line
Publications

DOI=10.1007/BF02619074
Roland Anthony Pattillo, Anna C.F. Ruckert, Robert O. Hussa, Rene Bernstein, Eleanor Mary Delfs;
The JAr cell line -- continuous human multihormone production and controls.
In Vitro 6:398-399(1971)

PubMed=7153601
Shigeru Sasaki, Paul K. Katayama, Mark Roesler, Roland Anthony Pattillo, Richard F. Mattingly, Kimiyasu Ohkawa;
Cytogenetic analysis of choriocarcinoma cell lines.
Nihon Sanka Fujinka Gakkai Zasshi 34:2253-2256(1982)

PubMed=4038916; DOI=10.1016/0165-4608(85)90052-4
David M. Sheppard, Rosemary A. Fisher, Sylvia Dorothy Lawler;
Karyotypic analysis and chromosome polymorphisms in four choriocarcinoma cell lines.
Cancer Genet. Cytogenet. 16:251-258(1985)

PubMed=2878840; DOI=10.1016/0020-7292(86)90088-3
Kohki Yamashita, Takafumi Nakamura, Tetsuya Shimizu, Makoto Katagiri, Hisami Ikeda;
Expression of HLA class I and class II antigens in human choriocarcinoma cell lines.
Int. J. Gynaecol. Obstet. 24:301-307(1986)

PubMed=3518877; DOI=10.3109/07357908609038260
Jorgen Fogh;
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=2720636; DOI=10.1016/0165-4608(89)90664-X
Urvashi Surti, Rezvan Habibian;
Chromosomal rearrangement in choriocarcinoma cell lines.
Cancer Genet. Cytogenet. 38:229-240(1989)

PubMed=7937597; DOI=10.1016/0143-4004(94)90008-6
Ruth Grummer, Hans-Peter Hohn, Marc M. Mareel, Hans-Werner Denker;
Adhesion and invasion of three human choriocarcinoma cell lines into human endometrium in a three-dimensional organ culture system.
Placenta 15:411-429(1994)

PubMed=7716126; DOI=10.1016/0143-4004(95)90079-9
Agnieszka Maria Mitchell, Alpha S. Yap, Elizabeth J. Payne, Simon W. Manley, Robin H. Mortimer;
Characterization of cell polarity and epithelial junctions in the choriocarcinoma cell line, JAR.
Placenta 16:31-39(1995)

PubMed=7819056; DOI=10.1038/bjc.1995.3; PMCID=PMC2033447
Yuji Yaginuma, Tsuyoshi Yamashita, Naoyuki Takuma, Hideto Katayama, Mutsuo Ishikawa;
Analysis of the p53 gene in human choriocarcinoma cell lines.
Br. J. Cancer 71:9-12(1995)

DOI=10.1007/0-306-46861-1_8
Vadivel Ganapathy, Puttur D. Prasad, Frederick H. Leibach;
Choriocarcinoma.
(In book chapter) Human cell culture. Vol. 2. Cancer cell lines part 2; Masters, John R.W. & Palsson, Bernhard Orn (eds.); pp.141-147; Kluwer Academic Publishers; New York; USA (1999)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa, Jonathan Hinton, Ciara Fahey ...Show all 22 authors... , Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera, Rui Wang, Angela Tam ...Show all 22 authors... , Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=24098444; DOI=10.1371/journal.pone.0076205; PMCID=PMC3788803
Sanna Vuoristo, Sanna Toivonen, Jere Weltner, Milla Mikkola, Jarkko Ustinov, Ras Trokovic, Jaan Palgi, Riikka J. Lund, Timo Tuuri, Timo Otonkoski;
A novel feeder-free culture system for human pluripotent stem cell culture and induced pluripotent stem cell derivation.
PLoS ONE 8:e76205.1-e76205.14(2013)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer, Patricia Greninger, Ewald van Dyk ...Show all 39 authors... , Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28161053; DOI=10.1016/j.placenta.2016.12.007
Wassim Abou-Kheir, Joanna Barrak, Ola Hadadeh, Georges Daoud;
HTR-8/SVneo cell line contains a mixed population of cells.
Placenta 50:1-7(2017)

PubMed=28534963; DOI=10.3892/or.2017.5661
Kimihiro Nishino, Eiko Yamamoto, Kaoru Niimi, Yoko Sekiya, Yoriko Yamashita, Fumitaka Kikkawa;
N-acetylglucosaminyltransferase IVa promotes invasion of choriocarcinoma.
Oncol. Rep. 38:440-448(2017)

PubMed=28724925; DOI=10.1038/s41598-017-06364-z; PMCID=PMC5517571
Mario Rothbauer, Nilaykumar Patel, Hajnalka Gondola, Monika Siwetz, Berthold Huppertz, Peter Ertl;
A comparative study of five physiological key parameters between four different human trophoblast-derived cell lines.
Sci. Rep. 7:5892-5892(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=33096371; DOI=10.1016/j.placenta.2020.10.011
Maja Weber, Anja Weise, Faezeh Vasheghani, Claudia Gohner, Justine Sayuri Fitzgerald, Thomas Liehr, Udo R. Markert;
Cytogenomics of six human trophoblastic cell lines.
Placenta 103:72-75(2021)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker, Jennifer Koh, Howard Lightfoot ...Show all 32 authors... , Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) ATCC; HTB-144
BCRC; 60491
CLS; 300221
DSMZ; ACC-462
IZSLER; BS TCL 182
KCLB; 30144
Cell line databases/resources CLO; CLO_0007011
MCCL; MCC:0000254
cancercelllines; CVCL_0360
CCRID; 3101HUMTCHu156
Cell_Model_Passport; SIDM01039
Cosmic-CLP; 907175
DepMap; ACH-001529
DSMZCellDive; ACC-462
IGRhCellID; JAR
LINCS_LDP; LCL-1491
TOKU-E; 2064
Anatomy/cell type resources BTO; BTO_0001585
Biological sample resources BioSample; SAMN01821568
BioSample; SAMN01821637
BioSample; SAMN03472717
Chemistry resources ChEMBL-Cells; CHEMBL3307657
ChEMBL-Targets; CHEMBL614587
GDSC; 907175
PharmacoDB; JAR_676_2019
PubChem_Cell_line; CVCL_0360
Encyclopedic resources Wikidata; Q54898511
Experimental variables resources EFO; EFO_0002211
Gene expression databases ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM827264
GEO; GSM1669947
Polymorphism and mutation databases Cosmic; 907175
Cosmic; 2077193
IARC_TP53; 21417
Progenetix; CVCL_0360
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number43