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Cellosaurus Hepa 1-6 (CVCL_0327)

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Cell line name Hepa 1-6
Synonyms HEPA 1-6; Hepa-1-6; Hepa1-6
Accession CVCL_0327
Resource Identification Initiative To cite this cell line use: Hepa 1-6 (RRID:CVCL_0327)
Comments Doubling time: 26.99 +- 1.93 hours (PubMed=28152020); ~30 hours (DSMZ=ACC-175).
Omics: Deep phosphoproteome analysis.
Omics: Deep proteome analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Disease Hepatocellular carcinoma of the mouse (NCIt: C38756)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C57L.
Hierarchy Parent: CVCL_S550 (Hepa-1)
CVCL_IU28 (Dt81Hepa1-6)CVCL_C8Y7 (Hepa 1-6-Luc)CVCL_A5BH (Hepa 1-6/10R)
CVCL_RI52 (Hepa/8F5)CVCL_RA18 (Hepa1-6-eGFP-Puro)CVCL_RA19 (Hepa1-6-Fluc-Neo)
CVCL_RA20 (Hepa1-6-Fluc-Neo/eGFP-Puro)CVCL_RA21 (Hepa1-6-iRFP-Puro)CVCL_B6ZC (Res1-6)
Sex of cell Female
Category Cancer cell line
STR profile Source(s): PubMed=31220119; Ubigene

Mouse STR 1-114,15,16
Mouse STR 1-213
Mouse STR 2-114
Mouse STR 3-210
Mouse STR 4-218.3,19.3
Mouse STR 5-517
Mouse STR 6-418,19
Mouse STR 6-715
Mouse STR 7-125.2
Mouse STR 8-115
Mouse STR 11-216
Mouse STR 12-117
Mouse STR 13-117.1
Mouse STR 15-317,18,19
Mouse STR 17-214
Mouse STR 18-316,17
Mouse STR 19-210,11
Mouse STR X-125

Run an STR similarity search on this cell line

PubMed=11004682; DOI=10.1002/1097-0215(20001015)88:2<287::AID-IJC22>3.0.CO;2-U
Briz O., Serrano M.A., Macias R.I.R., Marin J.J.G.
Overcoming cisplatin resistance in vitro by a free and liposome-encapsulated bile acid derivative: BAMET-R2.
Int. J. Cancer 88:287-292(2000)

PubMed=12606785; DOI=10.1124/mol.63.3.742
Briz O., Macias R.I.R., Vallejo M., Silva A., Serrano M.A., Marin J.J.G.
Usefulness of liposomes loaded with cytostatic bile acid derivatives to circumvent chemotherapy resistance of enterohepatic tumors.
Mol. Pharmacol. 63:742-750(2003)

PubMed=25193168; DOI=10.1074/mcp.M113.037291
Hornburg D., Drepper C., Butter F., Meissner F., Sendtner M., Mann M.
Deep proteomic evaluation of primary and cell line motoneuron disease models delineates major differences in neuronal characteristics.
Mol. Cell. Proteomics 13:3410-3420(2014)

PubMed=26280412; DOI=10.1038/nbt.3327
Humphrey S.J., Azimifar S.B., Mann M.
High-throughput phosphoproteomics reveals in vivo insulin signaling dynamics.
Nat. Biotechnol. 33:990-995(2015)

PubMed=28152020; DOI=10.1371/journal.pone.0171215
Lacoste B., Raymond V.-A., Cassim S., Lapierre P., Bilodeau M.
Highly tumorigenic hepatocellular carcinoma cell line with cancer stem cell-like properties.
PLoS ONE 12:E0171215-E0171215(2017)

PubMed=31220119; DOI=10.1371/journal.pone.0218412
Almeida J.L., Dakic A., Kindig K., Kone M., Letham D.L.D., Langdon S., Peat R., Holding-Pillai J., Hall E.M., Ladd M., Shaffer M.D., Berg H., Li J.-L., Wigger G., Lund S., Steffen C.R., Fransway B.B., Geraghty B., Natoli M., Bauer B., Gollin S.M., Lewis D.W., Reid Y.A.
Interlaboratory study to validate a STR profiling method for intraspecies identification of mouse cell lines.
PLoS ONE 14:E0218412-E0218412(2019)

Cell line collections (Providers) AddexBio; C0015005/4999
ATCC; CRL-1830
BCRC; 60051
CLS; 400474
ECACC; 92110305
NCBI_Iran; C517
RCB; RCB1638
Ubigene; YC-A005
Cell line databases/resources CLO; CLO_0003711
CLO; CLO_0050769
MCCL; MCC:0000223
CLDB; cl1658
CLDB; cl1659
CLDB; cl5199
CCRID; 1101MOU-PUMC000106
CCRID; 6101MOU-CERC000105
DSMZCellDive; ACC-175
Lonza; 830
Anatomy/cell type resources BTO; BTO:0002895
Biological sample resources BioSample; SAMN11397636
Encyclopedic resources Wikidata; Q54882820
Gene expression databases GEO; GSM1374085
GEO; GSM1374086
GEO; GSM1374087
GEO; GSM1374088
GEO; GSM1374089
GEO; GSM1374090
Proteomic databases PRIDE; PXD001792
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number25