Cellosaurus cell line Hepa 1-6 (CVCL

Cellosaurus Hepa 1-6 (CVCL_0327)

[Text version]

Cell line name

Hepa 1-6

Synonyms

HEPA 1-6; Hepa-1-6; Hepa1-6

Accession

CVCL_0327

Resource Identification Initiative

To cite this cell line use: Hepa 1-6 (RRID:CVCL_0327)

Comments

Characteristics: Secretes several liver products including albumin, alpha-fetoprotein, alpha 1-antitrypin and amylase (ECACC=92110305).
Doubling time: 26.99 +- 1.93 hours (PubMed=28152020); ~30 hours (DSMZ=ACC-175).
Omics: Proteomics.
Omics: Proteomics; PTM; Phosphorylation.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Variations; Array-based CGH.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.

Disease

Hepatocellular carcinoma of the mouse (NCIt: C38756)

Species of origin

Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C57L/J.

Hierarchy

Parent: CVCL_S550 (Hepa-1)
Children:

CVCL_IU28 (Dt81Hepa1-6)	CVCL_C8Y7 (Hepa 1-6-Luc)	CVCL_A5BH (Hepa 1-6/10R)
CVCL_RI52 (Hepa/8F5)	CVCL_RA18 (Hepa1-6-eGFP-Puro)	CVCL_RA19 (Hepa1-6-Fluc-Neo)
CVCL_RA20 (Hepa1-6-Fluc-Neo/eGFP-Puro)	CVCL_RA21 (Hepa1-6-iRFP-Puro)	CVCL_E1L8 (HyCyte Hepa 1-6 KO-mEno1)
CVCL_D6BL (HyCyte Hepa 1-6 KO-mSlc39a1)	CVCL_E1L9 (HyCyte Hepa 1-6 KO-mTrp53)	CVCL_E3HH (HyCyte Hepa 1-6-Luc)
CVCL_B6ZC (Res1-6)	CVCL_E0V9 (Ubigene Hepa 1-6 Bcl9 KO)	CVCL_E0VA (Ubigene Hepa 1-6 C3 KO)
CVCL_E0VB (Ubigene Hepa 1-6 Clec10a KO)	CVCL_E0VC (Ubigene Hepa 1-6 Hif1a KO)	CVCL_E0VD (Ubigene Hepa 1-6 Mettl4 KO)

Sex of cell

Female

Age at sampling

Age unspecified

Category

Cancer cell line

STR profile

Source(s): CLS=400474; PubMed=31220119; Ubigene=YC-A005

Markers:

Mouse STR 1-1	14,15,16
Mouse STR 1-2	13
Mouse STR 2-1	14
Mouse STR 3-2	10
Mouse STR 4-2	18.3,19.3
Mouse STR 5-5	17
Mouse STR 6-4	18,19
Mouse STR 6-7	15
Mouse STR 7-1	25.2
Mouse STR 8-1	15
Mouse STR 11-2	16
Mouse STR 12-1	17
Mouse STR 13-1	17.1
Mouse STR 15-3	17,18,19
Mouse STR 17-2	14
Mouse STR 18-3	16,17
Mouse STR 19-2	10,11
Mouse STR X-1	25

Web pages

Provider; Altogen; Xenograft model; https://altogenlabs.com/xenograft-models/liver-cancer-xenograft/hepa1-6-xenograft-model/

Publications

PubMed=11004682; DOI=10.1002/1097-0215(20001015)88:2<287::AID-IJC22>3.0.CO;2-U
Oscar Briz, Maria Angeles Serrano, Rocio I.R. Macias, Jose J.G. Marin;
Overcoming cisplatin resistance in vitro by a free and liposome-encapsulated bile acid derivative: BAMET-R2.
Int. J. Cancer 88:287-292(2000)

PubMed=12606785; DOI=10.1124/mol.63.3.742
Oscar Briz, Rocio I.R. Macias, Marta Vallejo, Augusto Silva, Maria Angeles Serrano, Jose J.G. Marin;
Usefulness of liposomes loaded with cytostatic bile acid derivatives to circumvent chemotherapy resistance of enterohepatic tumors.
Mol. Pharmacol. 63:742-750(2003)

PubMed=25193168; DOI=10.1074/mcp.M113.037291; PMCID=PMC4256493
Daniel Hornburg, Carsten Drepper, Falk Butter, Felix Meissner, Michael Sendtner, Matthias Mann;
Deep proteomic evaluation of primary and cell line motoneuron disease models delineates major differences in neuronal characteristics.
Mol. Cell. Proteomics 13:3410-3420(2014)

PubMed=26280412; DOI=10.1038/nbt.3327
Sean J. Humphrey, Seyed Babak Azimifar, Matthias Mann;
High-throughput phosphoproteomics reveals in vivo insulin signaling dynamics.
Nat. Biotechnol. 33:990-995(2015)

PubMed=28152020; DOI=10.1371/journal.pone.0171215; PMCID=PMC5289561
Benoit Lacoste, Valerie-Ann Raymond, Shamir Cassim, Pascal Lapierre, Marc Bilodeau;
Highly tumorigenic hepatocellular carcinoma cell line with cancer stem cell-like properties.
PLoS ONE 12:e0171215.1-e0171215.19(2017)

PubMed=31220119; DOI=10.1371/journal.pone.0218412; PMCID=PMC6586308
Jamie L. Almeida, Aleksandra Dakic, Karin Kindig, Maikan Kone, Deborah Lee Dormady Letham, Scott Langdon, Ruth Peat, Jayamalini Holding-Pillai, Erin M. Hall, Mark Ladd, Megan D. Shaffer ...Show all 23 authors... , Heath Berg, Jin-Liang Li, Georges Wigger, Steve Lund, Carolyn R. Steffen, Barbara B. Fransway, Bob Geraghty, Manuela Natoli, Beth A. Bauer, Susanne M. Gollin, Dale W. Lewis, Yvonne A. Reid; Show fewer authors
Interlaboratory study to validate a STR profiling method for intraspecies identification of mouse cell lines.
PLoS ONE 14:e0218412.1-e0218412.24(2019)

DOI=10.37421/2684-4567.2021.5.121
Shaymaa Azawi, Katja Piaszinski, Milash Balachandran, Thomas Liehr, Martina Rincic;
Molecular cytogenomic characterization of two murine liver cancer cell lines: MH-22A and Hepa 1-6.
J. Genet. Genomes 5:1.1-1.6(2021)

Cross-references

Cell line collections (Providers)