Cellosaurus logo
expasy logo

Cellosaurus GT1-7 (CVCL_0281)

[Text version]
Cell line name GT1-7
Accession CVCL_0281
Secondary accession CVCL_8221
Resource Identification Initiative To cite this cell line use: GT1-7 (RRID:CVCL_0281)
Comments Characteristics: Exhibits high levels of Gnrh1 expression and secretes GnRH in response to depolarization.
Genetic integration: Method=Transgenic mouse; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Misspelling: GTI-7; Note=Occasionally.
Derived from site: In situ; Brain, hypothalamus; UBERON=UBERON_0001898.
Cell type: GnRH neuron; CL=CL_0011111.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: (C57BL/6J x BALB/cJ) F2 transgenic with rat Gnrh1 promoter-Tg(SV40).
Hierarchy Parent: CVCL_6235 (GT1)
Children:
CVCL_RL73 (GT1-7-OX1)
Category Transformed cell line
STR profile Source(s): Millipore=SCC116

Markers:
Mouse STR 1-117
Mouse STR 1-219
Mouse STR 2-116
Mouse STR 3-214
Mouse STR 4-220.3,21.3
Mouse STR 5-513,17
Mouse STR 6-417,18
Mouse STR 6-717
Mouse STR 7-126.2
Mouse STR 8-113,16
Mouse STR 11-216,18
Mouse STR 12-116,17
Mouse STR 13-116.2,17
Mouse STR 15-322.3,23.3
Mouse STR 17-215
Mouse STR 18-316,17
Mouse STR 19-212,13
Mouse STR X-125,28

Run an STR similarity search on this cell line
Publications

PubMed=2196069; DOI=10.1016/0896-6273(90)90028-E
Pamela L. Mellon, Jolene J. Windle, Paul C. Goldsmith, Cheryl A. Padula, James L. Roberts, Richard I. Weiner;
Immortalization of hypothalamic GnRH neurons by genetically targeted tumorigenesis.
Neuron 5:1-10(1990)

PubMed=1714837; DOI=10.1210/endo-129-3-1584
William C. Wetsel, Pamela L. Mellon, Richard I. Weiner, Andres Negro-Vilar;
Metabolism of pro-luteinizing hormone-releasing hormone in immortalized hypothalamic neurons.
Endocrinology 129:1584-1595(1991)

PubMed=18406727; DOI=10.1016/1043-2760(95)00228-6
Margaret E. Wierman, Zhao-Qin Fang, Jadwiga K. Kepa;
GnRH gene expression in neuronal cell lines.
Trends Endocrinol. Metab. 7:60-65(1996)

PubMed=10830297; DOI=10.1210/endo.141.6.7494
Roberto Maggi, Federica Pimpinelli, Laura Molteni, Mario Milani, Luciano Martini, Flavio Piva;
Immortalized luteinizing hormone-releasing hormone neurons show a different migratory activity in vitro.
Endocrinology 141:2105-2112(2000)

Cross-references
Cell line collections (Providers) BCRJ; 0095
Millipore; SCC116
Cell line databases/resources MCCL; MCC:0000172
Lonza; 687
TOKU-E; 4052
Anatomy/cell type resources BTO; BTO_0002708
Encyclopedic resources Wikidata; Q54871828
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number24