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Cellosaurus DG-75 (CVCL_0244)

[Text version]
Cell line name DG-75
Synonyms D.G.-75; DG 75; DG75
Accession CVCL_0244
Resource Identification Initiative To cite this cell line use: DG-75 (RRID:CVCL_0244)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: MD Anderson Cell Lines Project.
Population: Jewish; Ashkenazi.
Virology: EBV-negative.
Virology: Infected by DG-75 retrovirus, a replication-competent, murine leukemia-related retrovirus. Constitutively produces the virus.
Doubling time: 18-20 hours (PubMed=188769); ~40-50 hours (DSMZ=ACC-83).
Microsatellite instability: Instable (MSI-high) (PubMed=9583678; PubMed=31068700; Sanger).
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: Proteome analysis by 2D-DE/MS.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Cell type: B-cell; CL=CL_0000236.
Sequence variations
  • Mutation; HGNC; 959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Homozygous (PubMed=9583678).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg283His (c.848G>A); ClinVar=VCV000142324; Zygosity=Heterozygous (PubMed=9525742).
HLA typing Source: PubMed=3037521
Class I
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American1.16
East Asian, North0
East Asian, South1.7
South Asian7.84
European, North25.56
European, South62.01
Disease Burkitt lymphoma (NCIt: C2912)
Burkitt lymphoma (ORDO: Orphanet_543)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 10Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-2625; Cosmic-CLP=906838; DSMZ=ACC-83; PubMed=17254797

CSF1PO9,10,11,12 (DSMZ=ACC-83)
10 (PubMed=17254797)
10,11,12 (ATCC=CRL-2625; Cosmic-CLP=906838)
D2S133817,23 (ATCC=CRL-2625)
17,22,23 (DSMZ=ACC-83)
D3S135815,16,17 (ATCC=CRL-2625; DSMZ=ACC-83)
16,17 (PubMed=17254797)
D7S82011,12 (PubMed=17254797)
11.3,12 (DSMZ=ACC-83)
11.3,12,12.3 (ATCC=CRL-2625)
12 (Cosmic-CLP=906838)
D8S117913,15 (ATCC=CRL-2625; PubMed=17254797)
14,15 (DSMZ=ACC-83)
D13S3179,11 (PubMed=17254797)
10,11 (DSMZ=ACC-83)
11 (ATCC=CRL-2625; Cosmic-CLP=906838)
D16S53911 (PubMed=17254797)
11,12 (Cosmic-CLP=906838)
11,12,13 (DSMZ=ACC-83)
12 (ATCC=CRL-2625)
D18S5111,13 (PubMed=17254797)
11,14,15,16 (ATCC=CRL-2625; DSMZ=ACC-83)
D21S1127,30 (PubMed=17254797)
29,31.2 (ATCC=CRL-2625; DSMZ=ACC-83)
FGA20,21,22,23,24 (DSMZ=ACC-83)
20,21,23 (ATCC=CRL-2625)
20,23 (PubMed=17254797)
Penta D12,13
Penta E6,7,17,19 (ATCC=CRL-2625)
7,16,17 (DSMZ=ACC-83)
vWA16,17,18,19 (DSMZ=ACC-83)
17,18 (ATCC=CRL-2625; PubMed=17254797)
17,18,19 (Cosmic-CLP=906838)

Run an STR similarity search on this cell line
Web pages https://tcpaportal.org/mclp/

PubMed=188769; DOI=10.1002/ijc.2910190105
Ben-Bassat H., Goldblum N., Mitrani-Rosenbaum S., Goldblum T., Yoffey J.M., Cohen M.M., Bentwich Z., Ramot B., Klein E., Klein G.
Establishment in continuous culture of a new type of lymphocyte from a 'Burkitt like' malignant lymphoma (line D.G.-75).
Int. J. Cancer 19:27-33(1977)

PubMed=2985879; DOI=10.1016/0145-2126(85)90084-0
Drexler H.G., Gaedicke G., Minowada J.
Isoenzyme studies in human leukemia-lymphoma cell lines -- 1 carboxylic esterase.
Leuk. Res. 9:209-229(1985)

PubMed=3159941; DOI=10.1016/0145-2126(85)90134-1
Drexler H.G., Gaedicke G., Minowada J.
Isoenzyme studies in human leukemia-lymphoma cell lines -- III Beta-hexosaminidase (E.C.
Leuk. Res. 9:549-559(1985)

PubMed=3874327; DOI=10.1016/0145-2126(85)90133-x
Drexler H.G., Gaedicke G., Minowada J.
Isoenzyme studies in human leukemia-lymphoma cells lines -- II. Acid phosphatase.
Leuk. Res. 9:537-548(1985)

PubMed=3037521; DOI=10.1073/pnas.84.13.4567
Masucci M.G., Torsteinsdottir S., Colombani J., Brautbar C., Klein E., Klein G.
Down-regulation of class I HLA antigens and of the Epstein-Barr virus-encoded latent membrane protein in Burkitt lymphoma lines.
Proc. Natl. Acad. Sci. U.S.A. 84:4567-4571(1987)

Dirks W.G., Zaborski M., Jager K., Challier C., Shiota M., Quentmeier H., Drexler H.G.
The (2;5)(p23;q35) translocation in cell lines derived from malignant lymphomas: absence of t(2;5) in Hodgkin-analogous cell lines.
Leukemia 10:142-149(1996)

PubMed=8896424; DOI=10.1182/blood.V88.9.3562.bloodjournal8893562
Chapman C.J., Zhou J.X., Gregory C.D., Rickinson A.B., Stevenson F.K.
VH and VL gene analysis in sporadic Burkitt's lymphoma shows somatic hypermutation, intraclonal heterogeneity, and a role for antigen selection.
Blood 88:3562-3568(1996)

PubMed=9473234; DOI=10.1182/blood.V91.5.1680
Klangby U., Okan I., Magnusson K.P., Wendland M., Lind P., Wiman K.G.
p16/INK4a and p15/INK4b gene methylation and absence of p16/INK4a mRNA and protein expression in Burkitt's lymphoma.
Blood 91:1680-1687(1998)

PubMed=9525742; DOI=10.1038/sj.onc.1201699
Crook T., Parker G.A., Rozycka M., Crossland S., Allday M.J.
A transforming p53 mutant, which binds DNA, transactivates and induces apoptosis reveals a nuclear:cytoplasmic shuttling defect.
Oncogene 16:1429-1441(1998)

PubMed=9583678; DOI=10.1038/sj.onc.1201704
Brimmell M., Mendiola R., Mangion J., Packham G.
BAX frameshift mutations in cell lines derived from human haemopoietic malignancies are associated with resistance to apoptosis and microsatellite instability.
Oncogene 16:1803-1812(1998)

PubMed=9685479; DOI=10.1093/nar/26.16.3651
Hultdin M., Gronlund E., Norrback K.-F., Eriksson-Lindstrom E., Just T., Roos G.
Telomere analysis by fluorescence in situ hybridization and flow cytometry.
Nucleic Acids Res. 26:3651-3656(1998)

PubMed=9770427; DOI=10.1006/viro.1998.9363
Raisch K.P., Kushnaryov V.M., Grossberg S.E., Cashdollar L.W.
Constitutive production of a murine retrovirus in the human B-lymphoblastoid cell line, DG-75.
Virology 250:135-139(1998)

PubMed=11425244; DOI=10.1002/1522-2683(200105)22:9<1867::AID-ELPS1867>3.0.CO;2-7
Poirier F., Pontet M., Labas V., le Caer J.-P., Sghiouar-Imam N., Raphael M., Caron M., Joubert-Caron R.
Two-dimensional database of a Burkitt lymphoma cell line (DG 75) proteins: protein pattern changes following treatment with 5'-azycytidine.
Electrophoresis 22:1867-1877(2001)

PubMed=12706092; DOI=10.1016/S0042-6822(02)00074-0
Raisch K.P., Pizzato M., Sun H.-Y., Takeuchi Y., Cashdollar L.W., Grossberg S.E.
Molecular cloning, complete sequence, and biological characterization of a xenotropic murine leukemia virus constitutively released from the human B-lymphoblastoid cell line DG-75.
Virology 308:83-91(2003)

PubMed=17254797; DOI=10.1016/j.biologicals.2006.10.001
Azari S., Ahmadi N., Jeddi-Tehrani M., Shokri F.
Profiling and authentication of human cell lines using short tandem repeat (STR) loci: report from the National Cell Bank of Iran.
Biologicals 35:195-202(2007)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=24590883; DOI=10.1002/gcc.22161
Murga Penas E.-M., Schilling G., Behrmann P., Klokow M., Vettorazzi E., Bokemeyer C., Dierlamm J.
Comprehensive cytogenetic and molecular cytogenetic analysis of 44 Burkitt lymphoma cell lines: secondary chromosomal changes characterization, karyotypic evolution, and comparison with primary samples.
Genes Chromosomes Cancer 53:497-515(2014)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cell line collections (Providers) ATCC; CRL-2625
NCBI_Iran; C495
Cell line databases/resources CLO; CLO_0002767
MCCL; MCC:0000134
CLDB; cl1051
cancercelllines; CVCL_0244
Cell_Model_Passport; SIDM00948
CGH-DB; 9196-4
Cosmic-CLP; 906838
DepMap; ACH-002232
DSMZCellDive; ACC-83
IGRhCellID; DG75
TOKU-E; 3578
Anatomy/cell type resources BTO; BTO:0003637
Biological sample resources BioSample; SAMN03471755
BioSample; SAMN03473403
Chemistry resources ChEMBL-Cells; CHEMBL3308527
ChEMBL-Targets; CHEMBL2366199
GDSC; 906838
PharmacoDB; DG75_290_2019
PubChem_Cell_line; CVCL_0244
Encyclopedic resources Wikidata; Q54831039
Experimental variables resources EFO; EFO_0002160
Gene expression databases ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM710428
GEO; GSM710444
GEO; GSM827239
GEO; GSM1669731
Polymorphism and mutation databases Cosmic; 906838
Cosmic; 931103
Cosmic; 1086327
Cosmic; 1118471
Cosmic; 1191698
Cosmic; 1588563
IARC_TP53; 8094
Progenetix; CVCL_0244
Proteomic databases PRIDE; PXD004181
PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number40