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Cellosaurus DG-75 (CVCL_0244)

[Text version]
Cell line name DG-75
Synonyms D.G.-75; DG 75; DG75
Accession CVCL_0244
Resource Identification Initiative To cite this cell line use: DG-75 (RRID:CVCL_0244)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: MD Anderson Cell Lines Project.
Population: Jewish; Ashkenazi.
Virology: EBV-negative.
Virology: Infected by DG-75 retrovirus, a replication-competent, murine leukemia-related retrovirus. Constitutively produces the virus.
Doubling time: 18-20 hours (PubMed=188769); 24 hours (PubMed=6169305); ~40-50 hours (DSMZ=ACC-83).
Microsatellite instability: Instable (MSI-high) (PubMed=9583678; PubMed=31068700; Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; 2DE-MS.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Cell type: B-cell; CL=CL_0000236.
Sequence variations
HLA typing Source: PubMed=3037521
Class I
HLA-AA*02,11
HLA-BB*39,41
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.72
Native American1.16
East Asian, North0
East Asian, South1.7
South Asian7.84
European, North25.56
European, South62.01
Disease Burkitt lymphoma (NCIt: C2912)
Burkitt lymphoma (ORDO: Orphanet_543)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_E5V5 (DG-75 CBF1 KO clone SM166C52)
Sex of cell Male
Age at sampling 10Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-2625; Cosmic-CLP=906838; DSMZ=ACC-83; PubMed=17254797

Markers:
AmelogeninX,Y
CSF1PO9,10,11,12 (DSMZ=ACC-83)
10 (PubMed=17254797)
10,11,12 (ATCC=CRL-2625; Cosmic-CLP=906838)
D2S133817,22,23 (DSMZ=ACC-83)
17,23 (ATCC=CRL-2625)
D3S135815,16,17 (ATCC=CRL-2625; DSMZ=ACC-83)
16,17 (PubMed=17254797)
D5S81812
D7S82011,12 (PubMed=17254797)
11.3,12 (DSMZ=ACC-83)
11.3,12,12.3 (ATCC=CRL-2625)
12 (Cosmic-CLP=906838)
D8S117913,15 (ATCC=CRL-2625; PubMed=17254797)
14,15 (DSMZ=ACC-83)
D13S3179,11 (PubMed=17254797)
10,11 (DSMZ=ACC-83)
11 (ATCC=CRL-2625; Cosmic-CLP=906838)
D16S53911 (PubMed=17254797)
11,12 (Cosmic-CLP=906838)
11,12,13 (DSMZ=ACC-83)
12 (ATCC=CRL-2625)
D18S5111,13 (PubMed=17254797)
11,14,15,16 (ATCC=CRL-2625; DSMZ=ACC-83)
D19S43312,13
D21S1127,30 (PubMed=17254797)
29,31.2 (ATCC=CRL-2625; DSMZ=ACC-83)
FGA20,21,22,23,24 (DSMZ=ACC-83)
20,21,23 (ATCC=CRL-2625)
20,23 (PubMed=17254797)
Penta D12,13
Penta E6,7,17,19 (ATCC=CRL-2625)
7,16,17 (DSMZ=ACC-83)
TH016,7
TPOX8,11
vWA16,17,18,19 (DSMZ=ACC-83)
17,18 (ATCC=CRL-2625; PubMed=17254797)
17,18,19 (Cosmic-CLP=906838)

Run an STR similarity search on this cell line
Web pages Info; MCLP; -; https://tcpaportal.org/mclp/
Publications

PubMed=188769; DOI=10.1002/ijc.2910190105
Hannah Ben-Bassat, Natan Goldblum, Stella Mitrani-Rosenbaum, Tamar Goldblum, Joseph Mendel Yoffey, Maimon Moses Cohen, Zvi Bentwich, Bracha Ramot, Eva Klein, George Klein;
Establishment in continuous culture of a new type of lymphocyte from a 'Burkitt like' malignant lymphoma (line D.G.-75).
Int. J. Cancer 19:27-33(1977)

PubMed=6169305; DOI=10.1128/AAC.20.2.151; PMCID=PMC181655
Arye Lazar, Shaul Reuveny, Moshe Minai, Abraham Traub, Avshalom Mizrahi;
Interferon production by a human lymphoblastoid cell line (DG-75) free of the Epstein-Barr genome.
Antimicrob. Agents Chemother. 20:151-154(1981)

PubMed=2985879; DOI=10.1016/0145-2126(85)90084-0
Hans Gunther Drexler, Gerhard Gaedicke, Jun Minowada;
Isoenzyme studies in human leukemia-lymphoma cell lines -- 1 Carboxylic esterase.
Leuk. Res. 9:209-229(1985)

PubMed=3159941; DOI=10.1016/0145-2126(85)90134-1
Hans Gunther Drexler, Gerhard Gaedicke, Jun Minowada;
Isoenzyme studies in human leukemia-lymphoma cell lines -- III Beta-hexosaminidase (E.C. 3.2.1.30).
Leuk. Res. 9:549-559(1985)

PubMed=3874327; DOI=10.1016/0145-2126(85)90133-x
Hans Gunther Drexler, Gerhard Gaedicke, Jun Minowada;
Isoenzyme studies in human leukemia-lymphoma cells lines -- II. Acid phosphatase.
Leuk. Res. 9:537-548(1985)

PubMed=3037521; DOI=10.1073/pnas.84.13.4567; PMCID=PMC305131
Maria Grazia Masucci, Sigurbjorg Torsteinsdottir, Jacques Colombani, Chaim Brautbar, Eva Klein, George Klein;
Down-regulation of class I HLA antigens and of the Epstein-Barr virus-encoded latent membrane protein in Burkitt lymphoma lines.
Proc. Natl. Acad. Sci. U.S.A. 84:4567-4571(1987)

PubMed=8558920
Wilhelm Gerhard Dirks, Margarete Zaborski, Kathrin Jager, Cecile Challier, Mami Shiota, Hilmar Quentmeier, Hans Gunther Drexler;
The (2;5)(p23;q35) translocation in cell lines derived from malignant lymphomas: absence of t(2;5) in Hodgkin-analogous cell lines.
Leukemia 10:142-149(1996)

PubMed=8896424; DOI=10.1182/blood.V88.9.3562.bloodjournal8893562
Caroline J. Chapman, Jo X. Zhou, Christopher D. Gregory, Alan Bernard Rickinson, Freda K. Stevenson;
VH and VL gene analysis in sporadic Burkitt's lymphoma shows somatic hypermutation, intraclonal heterogeneity, and a role for antigen selection.
Blood 88:3562-3568(1996)

PubMed=9473234; DOI=10.1182/blood.V91.5.1680
Ulf Klangby, Ismail Okan, Kristinn Petur Magnusson, Martin Wendland, Peter Lind, Klas G. Wiman;
p16/INK4a and p15/INK4b gene methylation and absence of p16/INK4a mRNA and protein expression in Burkitt's lymphoma.
Blood 91:1680-1687(1998)

PubMed=9525742; DOI=10.1038/sj.onc.1201699
Tim Crook, Gillian A. Parker, Magda Rozycka, Susan Crossland, Martin John Allday;
A transforming p53 mutant, which binds DNA, transactivates and induces apoptosis reveals a nuclear:cytoplasmic shuttling defect.
Oncogene 16:1429-1441(1998)

PubMed=9583678; DOI=10.1038/sj.onc.1201704
Matthew Brimmell, Rezzeline Mendiola, Jonathan Mangion, Graham Packham;
BAX frameshift mutations in cell lines derived from human haemopoietic malignancies are associated with resistance to apoptosis and microsatellite instability.
Oncogene 16:1803-1812(1998)

PubMed=9685479; DOI=10.1093/nar/26.16.3651; PMCID=PMC147775
Magnus Hultdin, Elisabeth Gronlund, Karl-Frederik Norrback, E. Eriksson-Lindstrom, Tom Just, Goran Roos;
Telomere analysis by fluorescence in situ hybridization and flow cytometry.
Nucleic Acids Res. 26:3651-3656(1998)

PubMed=9770427; DOI=10.1006/viro.1998.9363
Kevin P. Raisch, Vladimir M. Kushnaryov, Sidney Edward Grossberg, L. William Cashdollar;
Constitutive production of a murine retrovirus in the human B-lymphoblastoid cell line, DG-75.
Virology 250:135-139(1998)

PubMed=11425244; DOI=10.1002/1522-2683(200105)22:9<1867::AID-ELPS1867>3.0.CO;2-7
Florence Poirier, Michel Pontet, Valerie Labas, Jean-Pierre le Caer, Naima Sghiouar-Imam, Martine Raphael, Michel Caron, Raymonde Joubert-Caron;
Two-dimensional database of a Burkitt lymphoma cell line (DG 75) proteins: protein pattern changes following treatment with 5'-azycytidine.
Electrophoresis 22:1867-1877(2001)

PubMed=12706092; DOI=10.1016/S0042-6822(02)00074-0
Kevin P. Raisch, Massimo Pizzato, Hai-Yuan Sun, Yasuhiro Takeuchi, L. William Cashdollar, Sidney Edward Grossberg;
Molecular cloning, complete sequence, and biological characterization of a xenotropic murine leukemia virus constitutively released from the human B-lymphoblastoid cell line DG-75.
Virology 308:83-91(2003)

PubMed=17254797; DOI=10.1016/j.biologicals.2006.10.001
Shahram Azari, Nahid Ahmadi, Mahmood Jeddi-Tehrani, Fazel Shokri;
Profiling and authentication of human cell lines using short tandem repeat (STR) loci: report from the National Cell Bank of Iran.
Biologicals 35:195-202(2007)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=24590883; DOI=10.1002/gcc.22161
Eva-Maria Murga Penas, Georgia Schilling, Petra Behrmann, Marianne Klokow, Eik Vettorazzi, Carsten Bokemeyer, Judith Dierlamm;
Comprehensive cytogenetic and molecular cytogenetic analysis of 44 Burkitt lymphoma cell lines: secondary chromosomal changes characterization, karyotypic evolution, and comparison with primary samples.
Genes Chromosomes Cancer 53:497-515(2014)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) ABM; T8013
ATCC; CRL-2625
DSMZ; ACC-83
NCBI_Iran; C495
Cell line databases/resources CLO; CLO_0002767
MCCL; MCC:0000134
CLDB; cl1051
cancercelllines; CVCL_0244
Cell_Model_Passport; SIDM00948
CGH-DB; 9196-4
Cosmic-CLP; 906838
DepMap; ACH-002232
DSMZCellDive; ACC-83
IGRhCellID; DG75
LINCS_LDP; LCL-2019
TOKU-E; 3578
Anatomy/cell type resources BTO; BTO_0003637
Biological sample resources BioSample; SAMN03471755
BioSample; SAMN03473403
Chemistry resources ChEMBL-Cells; CHEMBL3308527
ChEMBL-Targets; CHEMBL2366199
GDSC; 906838
PharmacoDB; DG75_290_2019
PubChem_Cell_line; CVCL_0244
Encyclopedic resources Wikidata; Q54831039
Experimental variables resources EFO; EFO_0002160
Gene expression databases ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM710428
GEO; GSM710444
GEO; GSM827239
GEO; GSM1669731
Polymorphism and mutation databases Cosmic; 906838
Cosmic; 931103
Cosmic; 1086327
Cosmic; 1118471
Cosmic; 1191698
Cosmic; 1588563
IARC_TP53; 8094
Progenetix; CVCL_0244
Proteomic databases PRIDE; PXD004181
PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number42