ID DG-75 AC CVCL_0244 SY D.G.-75; DG 75; DG75 DR BTO; BTO_0003637 DR CLO; CLO_0002767 DR EFO; EFO_0002160 DR MCCL; MCC:0000134 DR CLDB; cl1051 DR ABM; T8013 DR ArrayExpress; E-MTAB-38 DR ArrayExpress; E-MTAB-783 DR ArrayExpress; E-MTAB-3610 DR ATCC; CRL-2625 DR BioSample; SAMN03471755 DR BioSample; SAMN03473403 DR cancercelllines; CVCL_0244 DR Cell_Model_Passport; SIDM00948 DR CGH-DB; 9196-4 DR ChEMBL-Cells; CHEMBL3308527 DR ChEMBL-Targets; CHEMBL2366199 DR Cosmic; 906838 DR Cosmic; 931103 DR Cosmic; 1086327 DR Cosmic; 1118471 DR Cosmic; 1191698 DR Cosmic; 1588563 DR Cosmic-CLP; 906838 DR DepMap; ACH-002232 DR DSMZ; ACC-83 DR DSMZCellDive; ACC-83 DR EGA; EGAS00001000978 DR GDSC; 906838 DR GEO; GSM710428 DR GEO; GSM710444 DR GEO; GSM827239 DR GEO; GSM1669731 DR IARC_TP53; 8094 DR IGRhCellID; DG75 DR LINCS_LDP; LCL-2019 DR NCBI_Iran; C495 DR PharmacoDB; DG75_290_2019 DR PRIDE; PXD004181 DR PRIDE; PXD030304 DR Progenetix; CVCL_0244 DR PubChem_Cell_line; CVCL_0244 DR TOKU-E; 3578 DR Wikidata; Q54831039 RX PubMed=188769; RX PubMed=2985879; RX PubMed=3037521; RX PubMed=3159941; RX PubMed=3874327; RX PubMed=6169305; RX PubMed=8558920; RX PubMed=8896424; RX PubMed=9473234; RX PubMed=9525742; RX PubMed=9583678; RX PubMed=9685479; RX PubMed=9770427; RX PubMed=11425244; RX PubMed=12706092; RX PubMed=17254797; RX PubMed=20164919; RX PubMed=20215515; RX PubMed=24590883; RX PubMed=27397505; RX PubMed=28196595; RX PubMed=30894373; RX PubMed=31068700; RX PubMed=35839778; WW Info; MCLP; -; https://tcpaportal.org/mclp/ CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Part of: COSMIC cell lines project. CC Part of: MD Anderson Cell Lines Project. CC Population: Jewish; Ashkenazi. CC Virology: EBV-negative. CC Virology: Infected by DG-75 retrovirus, a replication-competent, murine leukemia-related retrovirus. Constitutively produces the virus. CC Doubling time: 18-20 hours (PubMed=188769); 24 hours (PubMed=6169305); ~40-50 hours (DSMZ=ACC-83). CC HLA typing: A*02,11; B*39,41 (PubMed=3037521). CC Microsatellite instability: Instable (MSI-high) (PubMed=9583678; PubMed=31068700; Sanger). CC Sequence variation: Mutation; HGNC; HGNC:959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Homozygous (PubMed=9583678). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg283His (c.848G>A); ClinVar=VCV000142324; Zygosity=Heterozygous (PubMed=9525742). CC Omics: Genomics; DNA methylation analysis. CC Omics: Genomics; Whole exome sequencing. CC Omics: Phenotyping; Drug screening. CC Omics: Proteomics; 2DE-MS. CC Omics: Proteomics; Expression; Reverse-phase protein array. CC Omics: Proteomics; Quantitative. CC Omics: Transcriptomics; Microarray. CC Omics: Variations; SNP array analysis. CC Genome ancestry: African=1.72%; Native American=1.16%; East Asian, North=0%; East Asian, South=1.7%; South Asian=7.84%; European, North=25.56%; European, South=62.01% (PubMed=30894373). CC Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175. CC Cell type: B-cell; CL=CL_0000236. ST Source(s): ATCC=CRL-2625; Cosmic-CLP=906838; DSMZ=ACC-83; PubMed=17254797 ST Amelogenin: X,Y ST CSF1PO: 9,10,11,12 (DSMZ=ACC-83) ST CSF1PO: 10 (PubMed=17254797) ST CSF1PO: 10,11,12 (ATCC=CRL-2625; Cosmic-CLP=906838) ST D13S317: 9,11 (PubMed=17254797) ST D13S317: 10,11 (DSMZ=ACC-83) ST D13S317: 11 (ATCC=CRL-2625; Cosmic-CLP=906838) ST D16S539: 11 (PubMed=17254797) ST D16S539: 11,12 (Cosmic-CLP=906838) ST D16S539: 11,12,13 (DSMZ=ACC-83) ST D16S539: 12 (ATCC=CRL-2625) ST D18S51: 11,13 (PubMed=17254797) ST D18S51: 11,14,15,16 (ATCC=CRL-2625; DSMZ=ACC-83) ST D19S433: 12,13 ST D21S11: 27,30 (PubMed=17254797) ST D21S11: 29,31.2 (ATCC=CRL-2625; DSMZ=ACC-83) ST D2S1338: 17,22,23 (DSMZ=ACC-83) ST D2S1338: 17,23 (ATCC=CRL-2625) ST D3S1358: 15,16,17 (ATCC=CRL-2625; DSMZ=ACC-83) ST D3S1358: 16,17 (PubMed=17254797) ST D5S818: 12 ST D7S820: 11,12 (PubMed=17254797) ST D7S820: 11.3,12 (DSMZ=ACC-83) ST D7S820: 11.3,12,12.3 (ATCC=CRL-2625) ST D7S820: 12 (Cosmic-CLP=906838) ST D8S1179: 13,15 (ATCC=CRL-2625; PubMed=17254797) ST D8S1179: 14,15 (DSMZ=ACC-83) ST FGA: 20,21,22,23,24 (DSMZ=ACC-83) ST FGA: 20,21,23 (ATCC=CRL-2625) ST FGA: 20,23 (PubMed=17254797) ST Penta D: 12,13 ST Penta E: 6,7,17,19 (ATCC=CRL-2625) ST Penta E: 7,16,17 (DSMZ=ACC-83) ST TH01: 6,7 ST TPOX: 8,11 ST vWA: 16,17,18,19 (DSMZ=ACC-83) ST vWA: 17,18 (ATCC=CRL-2625; PubMed=17254797) ST vWA: 17,18,19 (Cosmic-CLP=906838) DI NCIt; C2912; Burkitt lymphoma DI ORDO; Orphanet_543; Burkitt lymphoma OX NCBI_TaxID=9606; ! Homo sapiens (Human) SX Male AG 10Y CA Cancer cell line DT Created: 04-04-12; Last updated: 10-04-25; Version: 42 CH CVCL_E5V5 ! DG-75 CBF1 KO clone SM166C52 // RX PubMed=3037521; DOI=10.1073/pnas.84.13.4567; PMCID=PMC305131; RA Masucci, Maria Grazia RA Torsteinsdottir, Sigurbjorg RA Colombani, Jacques RA Brautbar, Chaim RA Klein, Eva RA Klein, George RT "Down-regulation of class I HLA antigens and of the Epstein-Barr RT virus-encoded latent membrane protein in Burkitt lymphoma lines."; RL Proc. Natl. Acad. Sci. U.S.A. 84:4567-4571(1987). // RX PubMed=9770427; DOI=10.1006/viro.1998.9363; RA Raisch, Kevin P. RA Kushnaryov, Vladimir M. RA Grossberg, Sidney Edward RA Cashdollar, L. William RT "Constitutive production of a murine retrovirus in the human RT B-lymphoblastoid cell line, DG-75."; RL Virology 250:135-139(1998). // RX PubMed=17254797; DOI=10.1016/j.biologicals.2006.10.001; RA Azari, Shahram RA Ahmadi, Nahid RA Jeddi-Tehrani, Mahmood RA Shokri, Fazel RT "Profiling and authentication of human cell lines using short tandem RT repeat (STR) loci: report from the National Cell Bank of Iran."; RL Biologicals 35:195-202(2007). // RX PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103; RA Ghandi, Mahmoud RA Huang, Franklin W. RA Jane-Valbuena, Judit RA Kryukov, Gregory V. RA Lo, Christopher C. RA McDonald, E. Robert 3rd RA Barretina, Jordi Ginesta RA Gelfand, Ellen T. RA Bielski, Craig M. RA Li, Hao-Xin RA Hu, Kevin RA Andreev-Drakhlin, Alexander Y. RA Kim, Jaegil RA Hess, Julian M. RA Haas, Brian J. RA Aguet, Francois RA Weir, Barbara A. RA Rothberg, Michael V. RA Paolella, Brenton R. RA Lawrence, Michael Scott RA Akbani, Rehan RA Lu, Yi-Ling RA Tiv, Hong L. RA Gokhale, Prafulla C. RA de Weck, Antoine RA Mansour, Ali Amin RA Oh, Coyin RA Shih, Juliann RA Hadi, Kevin RA Rosen, Yanay RA Bistline, Jonathan RA Venkatesan, Kavitha RA Reddy, Anupama RA Sonkin, Dmitriy RA Liu, Manway RA Lehar, Joseph RA Korn, Joshua M. RA Porter, Dale A. RA Jones, Michael D. RA Golji, Javad RA Caponigro, Giordano RA Taylor, Jordan E. RA Dunning, Caitlin M. RA Creech, Amanda L. RA Warren, Allison C. RA McFarland, James M. RA Zamanighomi, Mahdi RA Kauffmann, Audrey RA Stransky, Nicolas RA Imielinski, Marcin RA Maruvka, Yosef E. RA Cherniack, Andrew D. RA Tsherniak, Aviad RA Vazquez, Francisca RA Jaffe, Jacob D. RA Lane, Andrew Alan RA Weinstock, David M. RA Johannessen, Cory M. RA Morrissey, Michael P. RA Stegmeier, Frank RA Schlegel, Robert RA Hahn, William Chun RA Getz, Gad RA Mills, Gordon B. RA Boehm, Jesse S. RA Golub, Todd Robert RA Garraway, Levi Alexander RA Sellers, William Raj RT "Next-generation characterization of the Cancer Cell Line RT Encyclopedia."; RL Nature 569:503-508(2019). // RX PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775; RA Goncalves, Emanuel RA Poulos, Rebecca C. RA Cai, Zhao-Xiang RA Barthorpe, Syd RA Manda, Srikanth S. RA Lucas, Natasha RA Beck, Alexandra RA Bucio-Noble, Daniel RA Dausmann, Michael RA Hall, Caitlin RA Hecker, Michael RA Koh, Jennifer RA Lightfoot, Howard RA Mahboob, Sadia RA Mali, Iman RA Morris, James RA Richardson, Laura RA Seneviratne, Akila J. RA Shepherd, Rebecca RA Sykes, Erin RA Thomas, Frances RA Valentini, Sara RA Williams, Steven G. RA Wu, Yang-Xiu RA Xavier, Dylan RA MacKenzie, Karen L. RA Hains, Peter G. RA Tully, Brett RA Robinson, Phillip James RA Zhong, Qing RA Garnett, Mathew J. RA Reddel, Roger Robert RT "Pan-cancer proteomic map of 949 human cell lines."; RL Cancer Cell 40:835-849.e8(2022). // RX PubMed=24590883; DOI=10.1002/gcc.22161; RA Murga Penas, Eva-Maria RA Schilling, Georgia RA Behrmann, Petra RA Klokow, Marianne RA Vettorazzi, Eik RA Bokemeyer, Carsten RA Dierlamm, Judith RT "Comprehensive cytogenetic and molecular cytogenetic analysis of 44 RT Burkitt lymphoma cell lines: secondary chromosomal changes RT characterization, karyotypic evolution, and comparison with primary RT samples."; RL Genes Chromosomes Cancer 53:497-515(2014). // RX PubMed=9525742; DOI=10.1038/sj.onc.1201699; RA Crook, Tim RA Parker, Gillian A. RA Rozycka, Magda RA Crossland, Susan RA Allday, Martin John RT "A transforming p53 mutant, which binds DNA, transactivates and RT induces apoptosis reveals a nuclear:cytoplasmic shuttling defect."; RL Oncogene 16:1429-1441(1998). // RX PubMed=9473234; DOI=10.1182/blood.V91.5.1680; RA Klangby, Ulf RA Okan, Ismail RA Magnusson, Kristinn Petur RA Wendland, Martin RA Lind, Peter RA Wiman, Klas G. RT "p16/INK4a and p15/INK4b gene methylation and absence of p16/INK4a RT mRNA and protein expression in Burkitt's lymphoma."; RL Blood 91:1680-1687(1998). // RX PubMed=3159941; DOI=10.1016/0145-2126(85)90134-1; RA Drexler, Hans Gunther RA Gaedicke, Gerhard RA Minowada, Jun RT "Isoenzyme studies in human leukemia-lymphoma cell lines -- III. RT Beta-hexosaminidase (E.C. 3.2.1.30)."; RL Leuk. Res. 9:549-559(1985). // RX PubMed=8558920; RA Dirks, Wilhelm Gerhard RA Zaborski, Margarete RA Jager, Kathrin RA Challier, Cecile RA Shiota, Mami RA Quentmeier, Hilmar RA Drexler, Hans Gunther RT "The (2;5)(p23;q35) translocation in cell lines derived from malignant RT lymphomas: absence of t(2;5) in Hodgkin-analogous cell lines."; RL Leukemia 10:142-149(1996). // RX PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076; RA Li, Jun RA Zhao, Wei RA Akbani, Rehan RA Liu, Wen-Bin RA Ju, Zhen-Lin RA Ling, Shi-Yun RA Vellano, Christopher P. RA Roebuck, Paul RA Yu, Qing-Hua RA Eterovic, Agda Karina RA Byers, Lauren Averett RA Davies, Michael A. RA Deng, Wan-Leng RA Gopal, Y.N. Vashisht RA Chen, Guo RA von Euw, Erika Maria RA Slamon, Dennis Joseph RA Conklin, Dylan RA Heymach, John Victor RA Gazdar, Adi F. RA Minna, John D. RA Myers, Jeffrey N. RA Lu, Yi-Ling RA Mills, Gordon B. RA Liang, Han RT "Characterization of human cancer cell lines by reverse-phase protein RT arrays."; RL Cancer Cell 31:225-239(2017). // RX PubMed=6169305; DOI=10.1128/AAC.20.2.151; PMCID=PMC181655; RA Lazar, Arye RA Reuveny, Shaul RA Minai, Moshe RA Traub, Abraham RA Mizrahi, Avshalom RT "Interferon production by a human lymphoblastoid cell line (DG-75) RT free of the Epstein-Barr genome."; RL Antimicrob. Agents Chemother. 20:151-154(1981). // RX PubMed=2985879; DOI=10.1016/0145-2126(85)90084-0; RA Drexler, Hans Gunther RA Gaedicke, Gerhard RA Minowada, Jun RT "Isoenzyme studies in human leukemia-lymphoma cell lines -- 1. RT Carboxylic esterase."; RL Leuk. Res. 9:209-229(1985). // RX PubMed=9685479; DOI=10.1093/nar/26.16.3651; PMCID=PMC147775; RA Hultdin, Magnus RA Gronlund, Elisabeth RA Norrback, Karl-Frederik RA Eriksson-Lindstrom, E. RA Just, Tom RA Roos, Goran RT "Telomere analysis by fluorescence in situ hybridization and flow RT cytometry."; RL Nucleic Acids Res. 26:3651-3656(1998). // RX PubMed=9583678; DOI=10.1038/sj.onc.1201704; RA Brimmell, Matthew RA Mendiola, Rezzeline RA Mangion, Jonathan RA Packham, Graham RT "BAX frameshift mutations in cell lines derived from human RT haemopoietic malignancies are associated with resistance to apoptosis RT and microsatellite instability."; RL Oncogene 16:1803-1812(1998). // RX PubMed=8896424; DOI=10.1182/blood.V88.9.3562.bloodjournal8893562; RA Chapman, Caroline J. RA Zhou, Jo X. RA Gregory, Christopher D. RA Rickinson, Alan Bernard RA Stevenson, Freda Kathryn RT "VH and VL gene analysis in sporadic Burkitt's lymphoma shows somatic RT hypermutation, intraclonal heterogeneity, and a role for antigen RT selection."; RL Blood 88:3562-3568(1996). // RX PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113; RA Bignell, Graham Robert RA Greenman, Christopher D. RA Davies, Helen R. RA Butler, Adam P. RA Edkins, Sarah RA Andrews, Jenny M. RA Buck, Gemma RA Chen, Lina RA Beare, David RA Latimer, Calli RA Widaa, Sara RA Hinton, Jonathan RA Fahey, Ciara RA Fu, Bei-Yuan RA Swamy, Sajani RA Dalgliesh, Gillian L. RA Teh, Bin Tean RA Deloukas, Panos RA Yang, Feng-Tang RA Campbell, Peter J. RA Futreal, P. Andrew RA Stratton, Michael Rudolf RT "Signatures of mutation and selection in the cancer genome."; RL Nature 463:893-898(2010). // RX PubMed=12706092; DOI=10.1016/S0042-6822(02)00074-0; RA Raisch, Kevin P. RA Pizzato, Massimo RA Sun, Hai-Yuan RA Takeuchi, Yasuhiro RA Cashdollar, L. William RA Grossberg, Sidney Edward RT "Molecular cloning, complete sequence, and biological characterization RT of a xenotropic murine leukemia virus constitutively released from the RT human B-lymphoblastoid cell line DG-75."; RL Virology 308:83-91(2003). // RX PubMed=188769; DOI=10.1002/ijc.2910190105; RA Ben-Bassat, Hannah RA Goldblum, Natan RA Mitrani-Rosenbaum, Stella RA Goldblum, Tamar RA Yoffey, Joseph Mendel RA Cohen, Maimon Moses RA Bentwich, Zvi RA Ramot, Bracha RA Klein, Eva RA Klein, George RT "Establishment in continuous culture of a new type of lymphocyte from RT a 'Burkitt like' malignant lymphoma (line D.G.-75)."; RL Int. J. Cancer 19:27-33(1977). // RX PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469; RA Iorio, Francesco RA Knijnenburg, Theo A. RA Vis, Daniel J. RA Bignell, Graham Robert RA Menden, Michael Patrick RA Schubert, Michael RA Aben, Nanne RA Goncalves, Emanuel RA Barthorpe, Syd RA Lightfoot, Howard RA Cokelaer, Thomas RA Greninger, Patricia RA van Dyk, Ewald RA Chang, Han RA de Silva, Heshani RA Heyn, Holger RA Deng, Xian-Ming RA Egan, Regina K. RA Liu, Qing-Song RA Mironenko, Tatiana RA Mitropoulos, Xeni RA Richardson, Laura RA Wang, Jin-Hua RA Zhang, Ting-Hu RA Moran, Sebastian RA Sayols, Sergi RA Soleimani, Maryam RA Tamborero, David RA Lopez-Bigas, Nuria RA Ross-Macdonald, Petra RA Esteller, Manel RA Gray, Nathanael S. RA Haber, Daniel Arie RA Stratton, Michael Rudolf RA Benes, Cyril Henri RA Wessels, Lodewyk F.A. RA Saez-Rodriguez, Julio RA McDermott, Ultan RA Garnett, Mathew J. RT "A landscape of pharmacogenomic interactions in cancer."; RL Cell 166:740-754(2016). // RX PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675; RA Dutil, Julie RA Chen, Zhi-Hua RA Monteiro, Alvaro N.A. RA Teer, Jamie K. RA Eschrich, Steven A. RT "An interactive resource to probe genetic diversity and estimated RT ancestry in cancer cell lines."; RL Cancer Res. 79:1263-1273(2019). // RX PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662; RA Rothenberg, S. Michael RA Mohapatra, Gayatry RA Rivera, Miguel N. RA Winokur, Daniel RA Greninger, Patricia RA Nitta, Mai RA Sadow, Peter M. RA Sooriyakumar, Gaya RA Brannigan, Brian W. RA Ulman, Matthew J. RA Perera, Rushika M. RA Wang, Rui RA Tam, Angela RA Ma, Xiao-Jun RA Erlander, Mark RA Sgroi, Dennis C. RA Rocco, James W. RA Lingen, Mark W. RA Cohen, Ezra E.W. RA Louis, David Neil RA Settleman, Jeffrey RA Haber, Daniel Arie RT "A genome-wide screen for microdeletions reveals disruption of RT polarity complex genes in diverse human cancers."; RL Cancer Res. 70:2158-2164(2010). // RX PubMed=11425244; DOI=10.1002/1522-2683(200105)22:9<1867::AID-ELPS1867>3.0.CO;2-7; RA Poirier, Florence RA Pontet, Michel RA Labas, Valerie RA le Caer, Jean-Pierre RA Sghiouar-Imam, Naima RA Raphael, Martine RA Caron, Michel RA Joubert-Caron, Raymonde RT "Two-dimensional database of a Burkitt lymphoma cell line (DG 75) RT proteins: protein pattern changes following treatment with RT 5'-azycytidine."; RL Electrophoresis 22:1867-1877(2001). // RX PubMed=3874327; DOI=10.1016/0145-2126(85)90133-x; RA Drexler, Hans Gunther RA Gaedicke, Gerhard RA Minowada, Jun RT "Isoenzyme studies in human leukemia-lymphoma cells lines -- II. Acid RT phosphatase."; RL Leuk. Res. 9:537-548(1985). //