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Cellosaurus C6 (CVCL_0194)

[Text version]
Cell line name C6
Synonyms C-6; C 6; RGC-6; RGC6; RGc6
Accession CVCL_0194
Secondary accession CVCL_4060
Resource Identification Initiative To cite this cell line use: C6 (RRID:CVCL_0194)
Comments Doubling time: 14.75 hours (PubMed=2303324); 24-28 hours (DOI=10.5005/jp-journals-10082-02230); ~24 hours (CLS=500142); ~25-30 hours (DSMZ=ACC-550).
Transformant: ChEBI; CHEBI:50102; N-methyl-N-nitrosourea (NMU).
Omics: Deep quantitative proteome analysis.
Omics: Mitochondrial genome sequenced.
Derived from site: In situ; Brain; UBERON=UBERON_0000955.
Disease Rat malignant glioma (NCIt: C64069)
Species of origin Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)
Breed/subspecies: Wistar Furth.
Hierarchy Children:
CVCL_ZB60 (C6 rho-0#14)CVCL_1970 (C6-BU-1)CVCL_6336 (C6-SF2)
CVCL_4V35 (C6/ACNU)CVCL_C9FG (C6/Cas9-hyg)CVCL_5657 (C6/lacZ)
CVCL_B7TS (C6rho0)CVCL_5H90 (C6TK-)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
Web pages https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/c/cell-lines-detail-129.html

Lightbody J.
Establishment of differentiated clonal strains of glial brain cells in culture.
Fed. Proc. 27:720-720(1968)

PubMed=4873531; DOI=10.1126/science.161.3839.370
Benda P., Lightbody J., Sato G.H., Levine L., Sweet W.H.
Differentiated rat glial cell strain in tissue culture.
Science 161:370-371(1968)

Stulberg C.S., Coriell L.L., Kniazeff A.J., Shannon J.E.
The animal cell culture collection.
In Vitro 5:1-16(1970)

Yoshida T., Shimizu K., Ushio Y., Mogami H., Sakamoto Y.
Possibility of overcoming of ACNU resistance in an ACNU-resistant subline of C6 rat glioma.
No To Shinkei 38:1065-1070(1986)

Brauner T., Schmid A., Hulser D.F.
Tumor cell invasion and gap junctional communication. I. Normal and malignant cells confronted in monolayer cultures.
Invasion Metastasis 10:18-30(1990)

Brauner T., Hulser D.F.
Tumor cell invasion and gap junctional communication. II. Normal and malignant cells confronted in multicell spheroids.
Invasion Metastasis 10:31-48(1990)

PubMed=19381449; DOI=10.1007/s11060-009-9875-7
Barth R.F., Kaur B.
Rat brain tumor models in experimental neuro-oncology: the C6, 9L, T9, RG2, F98, BT4C, RT-2 and CNS-1 gliomas.
J. Neurooncol. 94:299-312(2009)

PubMed=25492533; DOI=10.3109/19401736.2014.982619
Gao J., Hu L., Peng H.-H., Shi J.-G.
The complete mitochondrial genome sequence of the rat C6 glioma cell line.
Mitochondrial DNA 27:2188-2189(2016)

Kuduvalli S.S., Ramalakshmi O., Precilla S.D., Anitha T.S.
Evaluation of cell doubling time in C6 and Y79 cell lines based on seeding density.
SBV J. Basic Clin. Appl. Heatlh Sci. 2:146-149(2019)

PubMed=34917708; DOI=10.1016/j.dib.2021.107658
Silantyev A.S., Bukato O.N., Butenko I.O., Chernysheva A.A., Pobeguts O.V., Nosyrev A.E., Gurina O.I.
Proteomic dataset: profiling of glioma C6 and astrocytes rat cell lines before and after co-cultivation.
Data Brief 39:107658.1-107658.9(2021)

Cell line collections (Providers) ATCC; CCL-107
BCRC; 60046
BCRJ; 0057
CLS; 500142
ECACC; 92090409
ICLC; ATL95007
JCRB; IFO50110
KCB; KCB 93026YJ
KCLB; 10107
NCBI_Iran; C575
RCB; RCB2783
RCB; RCB2854
TKG; TKG 0242
TKG; TKG 0589
Cell line databases/resources CLO; CLO_0002072
CLO; CLO_0002140
CLO; CLO_0051387
CLO; CLO_0051388
MCCL; MCC:0000085
CLDB; cl579
CLDB; cl580
CLDB; cl581
CLDB; cl583
CLDB; cl5165
CCRID; 1101RAT-PUMC000131
DSMZCellDive; ACC-550
Lonza; 27
TOKU-E; 750
Anatomy/cell type resources BTO; BTO:0000529
Chemistry resources ChEMBL-Cells; CHEMBL3308345
ChEMBL-Targets; CHEMBL614657
PubChem_Cell_line; CVCL_0194
Encyclopedic resources Wikidata; Q54808212
Proteomic databases PRIDE; PXD026776
Entry history
Entry creation04-Apr-2012
Last entry update29-Jun-2023
Version number31