Cellosaurus logo
expasy logo

Cellosaurus Beta-TC-tet (CVCL_0185)

[Text][XML][JSON]
Cell line name Beta-TC-tet
Synonyms BetaTCtet; betaTC-tet
Accession CVCL_0185
Resource Identification Initiative To cite this cell line use: Beta-TC-tet (RRID:CVCL_0185)
Comments Characteristics: Expression of the SV40 T-antigen is under the control of the tet operator sequence. Shows growth arrest and further differentiation upon addition of 5 ng/ml tetracycline (PubMed=7724601).
Genetic integration: Method=Transgenic mouse; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Derived from site: In situ; Pancreas, islets of Langerhans; UBERON=UBERON_0000006.
Cell type: Pancreatic beta cell; CL=CL_0000169.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C3HeB/FeJ transgenic.
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Conditionally immortalized cell line
Web pages Info; COPE; -; http://www.cells-talk.com/index.php/page/copelibrary?key=betaTC-tet
Publications

PubMed=7724601; DOI=10.1073/pnas.92.8.3576; PMCID=PMC42210
Shimon Efrat, David Fusco-DeMane, Hadas Lemberg, Obaidullah Al Emran, Xiao-Rong Wang;
Conditional transformation of a pancreatic beta-cell line derived from transgenic mice expressing a tetracycline-regulated oncogene.
Proc. Natl. Acad. Sci. U.S.A. 92:3576-3580(1995)

PubMed=11900281; DOI=10.1080/15604280212526; PMCID=PMC2478570
Dalit Landesman-Milo, Shimon Efrat;
Growth factor-dependent proliferation of the pancreatic beta-cell line betaTC-tet: an assay for beta-cell mitogenic factors.
Int. J. Exp. Diabetes Res. 3:69-74(2002)

Cross-references
Cell line collections (Providers) ATCC; CRL-3237
Cell line databases/resources MCCL; MCC:0000076
Encyclopedic resources Wikidata; Q54796105
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number16